MET alterations and therapeutic strategies in non-small cell lung cancer- Journal of Army Medical University Vol. 44, Issue 24, Pages: 2453-2464(2022)
- 作者机构：
200030 上海，上海交通大学医学院附属胸科医院
- 作者简介：
- 基金信息：the Key Program of National Natural Science Foundation of China(82030045);the Project of "Platform+Project" Framework Construction of Lung Cancer Center of Shanghai Chest Hospital(2020NMDTP)
DOI：10.16016/j.2097-0927.202208115
CLC： R394.3;R730.53;R734.2Received：17 August 2022，
Revised：2022-10-28，
Published：30 December 2022
- 稿件说明：
移动端阅览
Jian LI, Shun LU.
MET alterations and therapeutic strategies in non-small cell lung cancer[J]. Journal of Army Medical University, 2022, 44(24): 2453-2464.Jian LI, Shun LU.
MET alterations and therapeutic strategies in non-small cell lung cancer[J]. Journal of Army Medical University, 2022, 44(24): 2453-2464. DOI： 10.16016/j.2097-0927.202208115.
摘要
MET
基因在维持细胞稳态、运动和凋亡中起着至关重要的作用。在肿瘤中，
MET
基因改变促进肿瘤细胞的增殖、侵袭和转移。在非小细胞肺癌(non-small cell lung cancer，NSCLC)中，
MET
基因改变包括
MET
14号外显子跳跃突变(
MET
ex14)、
MET
扩增(
MET
amp)、
MET
融合(
MET
fusion)、MET酪氨酸激酶区域的错义突变(MET-tyrosine kinase domain，MET-TKD)和MET蛋白过度表达。基于对
MET
基因及信号通路的认识，研究者们提出了三种靶向
MET
的方法：
MET
酪氨酸激酶抑制剂(tyrosine kinase inhibitor，TKI)，包括克唑替尼、卡马替尼、特泊替尼、赛沃替尼和卡博替尼；
MET
或其配体肝细胞生长因子(hepatocyte growth factor，HGF)单克隆抗体，包括依玛妥珠单抗(Emibetuzumab)，AV-299(Ficlatuzumab)；和MET或HGF抗体偶联药物和双特异性抗体，包括替利妥珠单抗(Telisotuzumab vedotin)和埃万妥单抗(Amivantamab)。本文对
MET
基因改变及其治疗进展进行述评，以期为
MET
基因改变的NSCLC患者的精准治疗推荐意见，为解决靶向治疗和免疫治疗的增效和耐药问题提供新思路。
Abstract
Mesenchymal to epithelial transition factor (
MET
) often plays a crucial role in cell homeostasis
motility and apoptosis
while its alterations can promote the proliferation
invasion and metastasis of tumors cells. In non-small cell lung cancer (NSCLC)
MET
genetic alterations include
MET
exon 14 skipping mutations
MET
amplification
MET
fusion
MET-tyrosine kinase domain and overexpression. Based on the understanding of the potential therapeutic targets of
MET
the investigators propose 3 strategies of MET targeting for clinical t
rials: MET tyrosine kinase inhibitors (TKIs)
including crizotinib
capmatinib
tepotinib
savolitinib
and cabozantinib; MET or hepatocyte growth factor (HGF) monoclonal antibodies
including emibetuzumab vedotin and ficlatuzumab; and MET or HGF antibody-drug conjugate and bispecific antibodies
including telisotuzumab and amivantamab. In this article
we review the progress of MET genetic alteration and its treatment progress
hope to provide more precise treatment for the patients with MET alterations
and provide new ideas for the efficacy and drug resistance of targeted therapy and immunotherapy.
关键词
Keywords
references
SIEGEL R L, MILLER K D, FUCHS H E, et al . Cancer statistics, 2022[J ] . CA Cancer J Clin, 2022, 72(1): 7-33. DOI: 10.3322/caac.21708.
TAN A C, TAN D S W. Targeted therapies for lung cancer patients with oncogenic driver molecular alterations[J]. J Clin Oncol, 2022, 40(6): 611-625. DOI: 10.1200/JCO.21.01626.
SACCO J J, CLAGUE M J.Dysregulation of the Met pathway in non-small cell lung cancer: implications for drug targeting and resistance[J]. Transl Lung Cancer Res, 2015, 4(3): 242-252. DOI: 10.3978/j.issn.2218-6751.2015.03.05.
SALGIA R. MET in lung cancer: biomarker selection based on scientific rationale[J]. Mol Cancer Ther, 2017, 16(4): 555-565. DOI: 10.1158/1535-7163.MCT-16-0472.
VAN DER STEEN N, GIOVANNETTI E, PAUWELS P, et al . cMET exon 14 skipping: from the structure to the clinic[J ] . J Thorac Oncol, 2016, 11(9): 1423-1432. DOI: 10.1016/j.jtho.2016.05.005.
DRILON A, CLARK J W, WEISS J, et al . Antitumor activity of crizotinib in lung cancers harboring a MET exon 14 altera-tion[J ] . Nat Med, 2020, 26(1): 47-51. DOI: 10.1038/s41591-019-0716-8.
WOLF J, SETO T, HAN J Y, et al . Capmatinib in MET exon 14-mutated or MET-amplified non-small-cell lung cancer[J ] . N Engl J Med, 2020, 383(10): 944-957. DOI: 10.1056/NEJMoa2002787.
PAIK P K, FELIP E, VEILLON R, et al . Tepotinib in non-small-cell lung cancer with MET exon 14 skipping mutations[J ] . N Engl J Med, 2020, 383(10): 931-943. DOI: 10.1056/NEJMoa2004407.
LU S, FANG J, LI X Y, et al . Once-daily savolitinib in Chinese patients with pulmonary sarcomatoid carcinomas and other non-small-cell lung cancers harbouring MET exon 14 skipping alterations: a multicentre, single-arm, open-label, phase 2 study[J ] . Lancet Respir Med, 2021, 9(10): 1154-1164. DOI: 10.1016/S2213-2600(21)00084-9.
FURGE K A, ZHANG Y W, VANDE WOUDE G F. Met receptor tyrosine kinase: enhanced signaling through adapter proteins[J]. Oncogene, 2000, 19(49): 5582-5589. DOI: 10.1038/sj.onc.1203859.
PESCHARD P, FOURNIER T M, LAMORTE L, et al . Mutation of the c-Cbl TKB domain binding site on the Met receptor tyrosine kinase converts it into a transforming protein[J ] . Mol Cell, 2001, 8(5): 995-1004. DOI: 10.1016/s1097-2765(01)00378-1.
OWUSU B Y, GALEMMO R, JANETKA J, et al . Hepatocyte growth factor, a key tumor-promoting factor in the tumor microenvironment[J ] . Cancers, 2017, 9(4): 35. DOI: 10.3390/cancers9040035.
GANDINO L, MUNARON L, NALDINI L, et al . Intra-cellular calcium regulates the tyrosine kinase receptor encoded by the MET oncogene[J ] . J Biol Chem, 1991, 266(24): 16098-16104. DOI: 10.1016/S0021-9258(18)98521-2.
REIS H, METZENMACHER M, GOETZ M, et al . MET expression in advanced non-small-cell lung cancer: effect on clinical outcomes of chemotherapy, targeted therapy, and immunotherapy[J ] . Clin Lung Cancer, 2018, 19(4): e441-e463. DOI: 10.1016/j.cllc.2018.03.010.
SCHROCK A B, FRAMPTON G M, SUH J, et al . Characterization of 298 patients with lung cancer harboring MET exon 14 skipping alterations[J ] . J Thorac Oncol, 2016, 11(9): 1493-1502. DOI: 10.1016/j.jtho.2016.06.004.
ENGELMAN J A, ZEJNULLAHU K, MITSUDOMI T, et al . MET amplification leads to gefitinib resistance in lung cancer by activating ERBB 3 signaling[J ] . Science, 2007, 316(5827): 1039-1043. DOI: 10.1126/science.1141478..
WANG Q M, YANG S, WANG K, et al . MET inhibitors for targeted therapy of EGFR TKI-resistant lung cancer[J ] . J Hematol Oncol, 2019, 12(1): 63. DOI: 10.1186/s13045-019-0759-9.
AI X H, YU Y F, ZHAO J, et al . Comprehensive analysis of MET mutations in NSCLC patients in a real-world setting[J ] . Ther Adv Med Oncol, 2022, 14: 1758835922111 2474. DOI: 10.1177/17588359221112474.
CAPPUZZO F, MARCHETTI A, SKOKAN M, et al . Increased MET gene copy number negatively affects survival of surgically resected non-small-cell lung cancer patients[J ] . J Clin Oncol, 2009, 27(10):1667-1674. DOI: 10.1200/JCO.2008.19.1635.
YIN X L, ZHANG T W, SU X Y, et al . Relationships between chromosome 7 gain, MET gene copy number increase and MET protein overexpression in Chinese papillary renal cell carcinoma patients[J ] . PLoS One, 2015, 10(12): e0143468. DOI: 10.1371 /journal.pone.0143468.
NAGATSUMA A K, AIZAWA M, KUWATA T, et al . Expression profiles of HER2, EGFR, MET and FGFR2 in a large cohort of patients with gastric adenocarcinoma[J ] . Gastric Cancer, 2015, 18(2): 227-238. DOI: 10.1007/s10120-014-0360-4.
OVERBECK T R, CRON D A, SCHMITZ K, et al . Top-level MET gene copy number gain defines a subtype of poorly differentiated pulmonary adenocarcinomas with poor prognosis[J ] . Transl Lung Cancer Res, 2020, 9(3): 603-616. DOI: 10.21037/tlcr-19-339.
NOONAN S A, BERRY L, LU X, et al . Identifying the appropriate FISH criteria for defining MET copy number-driven lung adenocarcinoma through oncogene overlap analysis[J ] . J Thorac Oncol, 2016, 11(8): 1293-1304. DOI: 10.1016/j.jtho.2016.04.033.
JARDIM D L F, TANG C, GAGLIATO D, et al . Analysis of 1 115 patients tested for MET amplification and therapy response in the MD Anderson Phase I Clinic[J ] . Clin Cancer Res, 2014, 20(24): 6336-6345. DOI: 10.1158/1078-0432.CCR-14-1293.
GUO R, LUO J, CHANG J, et al . MET-dependent solid tumours-molecular diagnosis and targeted therapy[J ] . Nat Rev Clin Oncol, 2020, 17(9): 569-587. DOI: 10.1038/s41571-020-0377-z.
MCCOMBIE W R, MCPHERSON J D, MARDIS E R. Next-generation sequencing technologies[J]. Cold Spring Harb Perspect Med, 2019, 9(11): a036798. DOI: 10.1101/cshperspect.a036798.
PAPADIMITRAKOPOULOU V A, WU Y L, HAN J Y, et al . Analysis of resistance mechanisms to osimertinib in patients with EGFR T790M advanced NSCLC from the AURA3 study[J ] . Ann Oncol, 2018, 29: viii741. DOI: 10.1093/annonc/mdy424.064.
LU X Y, PELED N, GREER J, et al . MET exon 14 mutation encodes an actionable therapeutic target in lung adenocarcinoma[J ] . Cancer Res, 2017, 77(16): 4498-4505. DOI: 10.1158/0008-5472.CAN-16-1944.
POIROT B, DOUCET L, BENHENDA S, et al . MET exon 14 alterations and new resistance mutations to tyrosine kinase inhibitors: risk of inadequate detection with current amplicon-based NGS panels[J ] . J Thorac Oncol, 2017, 12(10): 1582-1587. DOI: 10.1016/j.jtho.2017.07.026.
DAVIES K D, LOMBOY A, LAWRENCE C A, et al . DNA-based versus RNA-based detection of MET exon 14 skipping e vents in lung cancer[J ] . J Thorac Oncol, 2019, 14(4): 737-741. DOI: 10.1016/j.jtho.2018.12.020.
KIM E K, KIM K A, LEE C Y, et al . Molecular diagnostic assays and clinicopathologic implications of MET exon 14 skipping mutation in non-small-cell lung cancer[J ] . Clin Lung Cancer, 2019, 20(1): e123-e132. DOI: 10.1016/j.cllc.2018.10.004.
SPIGEL D R, ERVIN T J, RAMLAU R A, et al . Randomized phase Ⅱ trial of Onartuzumab in combination with erlotinib in patients with advanced non-small-cell lung cancer[J ] . J Clin Oncol, 2013, 31(32): 4105-4114. DOI: 10.1200/JCO.2012.47.4189.
AHN M J, DE MARINIS F, BONANNO L, et al . EP08.02-140 MET biomarker-based preliminary efficacy analysis in SAVANNAH: savolitinib+osimertinib in EGFRm NSCLC post-osimertinib[J ] . J Thorac Oncol, 2022, 17(9): S469-S470. DOI: 10.1016/j.jtho.2022.07.823.
KIM P, JIA P L, ZHAO Z M. Kinase impact assessment in the landscape of fusion genes that retain kinase domains: a pan-cancer study[J]. Brief Bioinform, 2018, 19(3): 450-460. DOI: 10.1093/bib/bbw127.
International Cancer Genome Consortium Pedbrain Tumor Project. Recurrent MET fusion genes represent a drug target in pediatric glioblastoma[J]. Nat Med, 2016, 22(11): 1314-1320. DOI: 10.1038/nm.4204.
BENAYED R, OFFIN M, MULLANEY K, et al . High yield of RNA sequencing for targetable kinase fusions in lung adenocarcinomas with no mitogenic driver alteration detected by DNA sequencing and low tumor mutation burden[J ] . Clin Cancer Res, 2019, 25(15): 4712-4722. DOI: 10.1158/1078-0432.CCR-19-0225.
PECCI F, RICCIUTI B, ALESSI J V M, et al . Activating MET kinase domain mutations define a novel molecular subtype of non-small cell lung cancer that is clinically targetable with the MET inhibitor elzovantinib (TPX-0022). J Clin Oncol, 2022, 40(16_suppl): 9124. DOI: 10.1200/jco.2022.40.16_suppl.9124.
WU Y L, CHENG Y, ZHOU J Y, et al . Tepotinib plus gefitinib in patients with EGFR-mutant non-small-cell lung cancer with MET overexpression or MET amplification and acquired resistance to previous EGFR inhibitor (INSIGHT study): an open-label, phase 1b/2, multicentre, randomised trial[J ] . Lancet Respir Med, 2020, 8(11): 1132-1143. DOI: 10.1016/S2213-2600(20)30154-5.
LU S, YU Y F, ZHOU J Y, et al . Abstract CT034: phase Ⅱ study of SCC244 in NSCLC patients haboring MET exon 14 skipping (METex14) mutations (GLORY study). Cancer Res, 2022, 82(12_Supplement): CT034. DOI: 10.1158/1538-7445.am2022-ct034.
SCAGLIOTTI G, MORO-SIBILOT D, KOLLMEIER J, et al . A randomized-controlled phase 2 study of the MET antibody emibetuzumab in combination with erlotinib as first-line treatment for EGFR mutation-positive NSCLC patients[J ] . J Thorac Oncol, 2020, 15(1): 80-90. DOI: 10.1016/j.jtho.2019.10.003.
CAMIDGE D R, BAR J, HORINOUCHI H, et al . Telisotuzumab vedotin (Teliso-V) monotherapy in patients (pts) with previously treated c-Met-overexpressing (OE) advanced non-small cell lung cancer (NSCLC). J Clin Oncol, 2022, 40(16_suppl): 9016. DOI: 10.1200/jco.2022.40.16_suppl.9016.
KREBS M, SPIRA A I, CHO B C, et al . Amivantamab in patients with NSCLC with MET exon 14 skipping mutation: updated results from the CHRYSALIS study[J ] . J Clin Oncol, 2022, 40(16_suppl): 9008. DOI: 10.1200/jco.2022.40.16_suppl.9008.
MOK T S K, GEATER S L, SU W C, et al . A randomized phase 2 study comparing the combination of ficlatuzumab and gefitinib with gefitinib alone in Asian patients with advanced stage pulmonary adenocarcinoma[J ] . J Thorac Oncol, 2016, 11(10): 1736-1744. DOI: 10.1016/j.jtho.2016.05.038.
DHILLON S. Capmatinib: first approval[J]. Drugs, 2020, 80(11): 1125-1131. DOI: 10.1007/s40265-020-01347-3.
KATO T, YANG J C H, AHN M J, et al . Tepotinib in Asian patients with advanced NSCLC with MET exon 14 ( MET ex14) skipping[J ] . J Clin Oncol, 2022, 40(16_suppl): 9120. DOI: 10.1200/jco.2022.40.16_suppl.9120..
MARKHAM A. Savolitinib: first approval[J]. Drugs, 2021, 81(14): 1665-1670. DOI: 10.1007/s40265-021-01584-0.
SEQUIST L V, HAN J Y, AHN M J, et al . Osimertinib plus savolitinib in patients with EGFR mutation-positive, MET-amplified, non-small-cell lung cancer after progression on EGFR tyrosine kinase inhibitors: interim results from a multicentre, open-label, phase 1b study[J ] . Lancet Oncol, 2020, 21(3): 373-386. DOI: 10.1016/S1470-2045(19)30785-5.
BAHCALL M, SIM T, PAWELETZ C P, et al . Acquired METD1228V mutation and resistance to MET inhibition in lung cancer[J ] . Cancer Discov, 2016, 6(12): 1334-1341. DOI: 10.1158/2159-8290.CD-16-0686.
FUJINO T, KOBAYASHI Y, SUDA K, et al . Sensitivity and resistance of MET exon 14 mutations in lung cancer to eight MET tyrosine kinase inhibitors in vitro [J ] . J Thorac Oncol, 2019, 14(10): 1753-1765. DOI: 10.1016/j.jtho.2019.06.023..
WANG S X Y, ZHANG B M, WAKELEE H A, et al . Case series of MET exon 14skipping mutation-positive non-small-cell lung cancers with response to crizotinib and cabozantinib[J ] . Anticancer Drugs, 2019, 30(5): 537-541. DOI: 10.1097/CAD.0000000000000765.
JIN W, SHAN B J, LIU H, et al . Acquired mechanism of crizotinib resistance in NSCLC with MET exon 14 skipping[J ] . J Thorac Oncol, 2019, 14(7): e137-e139. DOI: 10.1016/j.jtho.2019.04.021.
KLEMPNER S J, BORGHEI A, HAKIMIAN B, et al . Intracranial activity of cabozantinib in MET exon 14-positive NSCLC with brain metastases[J ] . J Thorac Oncol, 2017, 12(1): 152-156. DOI: 10.1016/j.jtho.2016.09.127.
ENGSTROM L D, ARANDA R, LEE M, et al . Glesatinib exhibits antitumor activity in lung cancer models and patients harboring MET exon 14 mutations and overcomes mutation-mediated resistance to type I MET inhibitors in nonclinical models[J ] . Clin Cancer Res, 2017, 23(21): 6661-6672. DOI: 10.1158/1078-0432.CCR-17-1192.
JAMME P, FERNANDES M, COPIN M C, et al . Alterations in the PI3K pathway drive resistance to MET inhibitors in NSCLC harboring MET exon 14 skipping mutations[J ] . J Thorac Oncol, 2020, 15(5): 741-751. DOI: 10.1016/j.jtho.2020.01.027.
LI A, YANG J J, ZHANG X C, et al . Acquired MET Y1248H and D1246N mutations mediate resistance to MET inhibitors in non-small cell lung cancer[J ] . Clin Cancer Res, 2017, 23(16): 4929-4937. DOI: 10.1158/1078-0432.ccr-16-3273..
SUZAWA K, OFFIN M, LU D, et al . Activation of KRAS mediates resistance to targeted therapy in MET exon 14-mutant non-small cell lung cancer[J ] . Clin Cancer Res, 2019, 25(4): 1248-1260. DOI: 10.1158/1078-0432.ccr-18-1640.
BROWER V. Onartuzumab ineffective in non-small-cell lung cancer[J]. Lancet Oncol, 2017, 18(2): e66. DOI: 10.1016/S1470-2045(16)30680-5.
CAMIDGE D R, MORAN T, DEMEDTS I, et al . A randomized, open-label phase Ⅱ study evaluating emibetuzumab plus erlotinib and emibetuzumab monotherapy in MET immunohistochemistry positive NSCLC patients with acquired resistance to erlotin ib[J ] . Clin Lung Cancer, 2022, 23(4): 300-310. DOI: 10.1016/j.cllc.2022.03.003.
STRICKLER J H, WEEKES C D, NEMUNAITIS J, et al . First-in-human phase I, dose-escalation and-expansion study of telisotuzumab vedotin, an antibody-drug conjugate targeting c-met, in patients with advanced solid tumors[J ] . J Clin Oncol, 2018, 36(33): 3298-3306. DOI: 10.1200/JCO.2018.78.7697.
CAMIDGE D R, BARLESI F, GOLDMAN J W, et al . Results of the phase 1b study of ABBV-399 (telisotuzumab vedotin; teliso-v) in combination with erlotinib in patients with c-Met+ non-small cell lung cancer by EGFR mutation status[J ] . J Clin Oncol, 2019, 37(15_suppl): 3011. DOI:10.1200/jco.2019.37.15_suppl.3011.
GOLDMAN J W, HORINOUCHI H, CHO B C, et al . Phase 1/1b study of telisotuzumab vedotin (Teliso-V) + osimertinib (Osi), after failure on prior Osi, in patients with advanced, c-Met overexpressing, EGFR -mutated non-small cell lung cancer (NSCLC). J Clin Oncol, 2022, 40(16_suppl): 9013. DOI: 10.1200/jco.2022.40.16_suppl.9013..
CAMIDGE D R, BARLESI F, GOLDMAN J W, et al . A phase 1b study of telisotuzumab vedotin in combination with nivolumab in patients with NSCLC[J ] . JTO Clin Res Rep, 2021, 3(1): 100262. DOI: 10.1016/j.jtocrr.2021.100262.
DRILON A E, AWAD M M, GADGEEL S M, et al . A phase 1/2 study of REGN5093-M114, a METxMET antibody-drug conjugate, in patients with mesenchymal epithelial transition factor (MET)-overexpressing NSCLC[J ] . J Clin Oncol, 2022, 40(16_suppl): TPS8593. DOI: 10.1200/jco.2022.40.16_suppl.tps8593.
HUANG L, XIE K, LI H W, et al . Suppression of c-met-overexpressing tumors by a novel c-met/CD3 bispecific antibody[J ] . Drug Des Devel Ther, 2020, 14: 3201-3214. DOI: 10.2147/DDDT.S254117.
PARK K, HAURA E B, LEIGHL N B, et al . Amivantamab in EGFR exon 20 insertion-mutated non-small-cell lung cancer progressing on platinumchemotherapy: initial results from the CHRYSALIS phase I study[J ] . J Clin Oncol, 2021, 39(30): 3391-3402. DOI: 10.1200/JCO.21.00662.
[Amivantamab OK'd for EGFR-mutant NSCLC[J ] . Cancer Discov, 2021, 11(7): 1604. DOI: 10.1158/2159-8290.CD-NB2021-0351 http://dx.doi.org/10.1158/2159-8290.CD-NB2021-0351 .
TARHINI A A, RAFIQUE I, FLOROS T, et al . Phase 1/2 study of rilotumumab (AMG 102), a hepatocyte growth factor i nhibitor, and erlotinib in patients with advanced non-small cell lung cancer[J ] . Cancer, 2017, 123(15): 2936-2944. DOI: 10.1002/cncr.30717.
GARASSINO M C, MARTELLI O, BROGGINI M, et al . Erlotinib versus docetaxel as second-line treatment of patients with advanced non-small-cell lung cancer and wild-type EGFR tumours (TAILOR): a randomised controlled trial[J ] . Lancet Oncol, 2013, 14(10): 981-988. DOI: 10.1016/S1470-2045(13)70310-3.
LINDNER A K, PICHLER M, THURNHER M, et al . Targeting c-met to improve immune checkpoint inhibition in metastatic renal cell carcinoma[J ] . Eur Urol, 2022, 81(1): 1-2. DOI: 10.1016/j.eururo.2021.10.025.
LI E L, HUANG X, ZHANG G, et al . Combinational blockade of MET and PD-L1 improves pancreatic cancer immunotherapeutic efficacy[J ] . J Exp Clin Cancer Res, 2021, 40(1): 279. DOI: 10.1186/s13046-021-02055-w.
KIM S Y, BOHLMAN S, YIN J, et al . Characterization of MET exon 14 skipping alterations ( MET ex14) in non-small cell lung cancer (NSCLC) using whole transcriptome sequencing (WTS). J Clin Oncol, 2022, 40(16_suppl): 9122. DOI: 10.1200/jco.2022.40.16_suppl.9122..
ZHANG Y, YANG Q F, ZENG X Y, et al . MET amplification attenuates lung tumor response to immunotherapy by inhibiting STING[J ] . Cancer Discov, 2021, 11(11): 2726-2737. DOI: 10.1158/2159-8290.CD-20-1500.
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