Acute adverse reactions and influencing factors of non-ionic iodine contrast in 332 683 patients undergoing contrast-enhanced CT scanning

Haiyan QIU; Lingru WANG; Jianjie LI; Lan CHEN; Xue LI

doi:10.16016/j.2097-0927.202208068

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Acute adverse reactions and influencing factors of non-ionic iodine contrast in 332 683 patients undergoing contrast-enhanced CT scanning

Clinical Medicine | 更新时间：2026-01-09

- Acute adverse reactions and influencing factors of non-ionic iodine contrast in 332 683 patients undergoing contrast-enhanced CT scanning
- Journal of Army Medical University Vol. 45, Issue 3, Pages: 257-264(2023)
- 作者机构：
  
  400042 重庆，陆军特色医学中心放射科
- 作者简介：
- 基金信息：
  
  the Joint Medical Research Project of Chongqing Science and Technology Commission and Chongqing Health Commission(2019ZDXM049)
- DOI：10.16016/j.2097-0927.202208068
  CLC： R181.22;R595.4;R981.1
- Received：09 August 2022，
  
  Revised：2022-09-20，
  
  Published：15 February 2023
- 稿件说明：
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Haiyan QIU, Lingru WANG, Jianjie LI, et al. Acute adverse reactions and influencing factors of non-ionic iodine contrast in 332 683 patients undergoing contrast-enhanced CT scanning[J]. Journal of Army Medical University, 2023, 45(3): 257-264.
DOI：

Haiyan QIU, Lingru WANG, Jianjie LI, et al. Acute adverse reactions and influencing factors of non-ionic iodine contrast in 332 683 patients undergoing contrast-enhanced CT scanning[J]. Journal of Army Medical University, 2023, 45(3): 257-264. DOI： 10.16016/j.2097-0927.202208068.

摘要

目的

分析真实世界中非离子碘对比剂(iodinated contrast medium，ICM)急性不良反应(acute adverse reactions，AARs)的发生情况及影响因素。

方法

采用回顾性病例对照研究，纳入2014-2020年在陆军特色医学中心使用ICM行CT增强检查的332 683例患者，其中男性184 498例，女性148 185例，年龄0~101(57.91±14.36)岁，根据是否发生AARs分为病例组和对照组。采用单因素和多因素Logistic回归分析筛出发生ICM-AARs的影响因素。

结果

病例组931例(发生ICM-AARs者)，对照组331 752例(未发生ICM-AARs者)。ICM-AARs总发生率为0.28%，其中轻度、中度、重度AARs分别占93.88%、4.83%、1.29%。回归分析结果显示，既往有ICM不良反应发生史(

=22.881

95%

: 16.235~32.246)、其他过敏史(

=4.406

95%

: 2.338~8.303)、患有哮喘(

=5.614

95%

: 2.596~12.138)与ICM-AARs的关联强度较强(

0.05)，性别、来源、药物过敏史、ICM类型和注射速度5个危险因素和高龄、ICM使用史、高血压病史3个保护因素(

=0.396~1.674)与ICM-AARs的关联强度较弱(

0.05)。

结论

ICM-AARs发生率为0.28%，以轻度不良反应为主。既往有ICM不良反应发生史、其他过敏史、哮喘是ICM-AARs发生的主要影响因素。

Abstract

Objective

To analyze the incidence and influencing factors of acute adverse reactions (AARs) of non-ionic iodine contrast medium (ICM) in the real world.

Methods

A retrospective case-control study was carried out on 332 683 patients receiving ICM-enhanced CT examination at our medical center from 2014 to 2020. They were 184 498 males and 148 185 females

at an age from 0 to 101 (57.91±14.36) years. According to experiencing AARs or not

the patients were divided into case group (ICM-AARs

=931) and control group (no ICM-AARs

=331 752). Single factor and multi factor logistic regression analyses were used to screen out the influencing factors of ICM-AARs.

Results

In the cohort

the incidence of ICM-AARs was 0.28% (931/332 683)

with mild

moderate and severe AARs accounted for 93.88%

4.83% and 1.29%

respectively. The results of regression analysis showed that history of ICM adverse reactions (

=22.881

95%

: 16.235~32.246)

history of other allergies (

=4.406

95%

: 2.338~8.303) and asthma (

=5.614

95%

: 2.596~12.138) were closely associated with the occurrence of ICM-AARs (

0.05). Gender

source

history of drug allergy

ICM type and injection speed were risk factors

while older age

history of ICM use and hypertension history were protective factors (

=0.396~1.674

0.05)

but the strengths of above associations with the ICM-AARs were relatively weak (

0.05).

Conclusion

The incidence of ICM-AARs is 0.28%

mainly mild adverse reactions. Previous history of ICM adverse reactions

other allergies

and asthma are the main factors affecting the occurrence of ICM-AARs.

关键词

Keywords

references

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