Value of cardiac magnetic resonance tissue tracking imaging for assessment of early cardiac function in rats with left ventricular remodeling

Haichen LI; Mei LI; Ruijue HUANG; Xiaojuan WEN; Mingxing ZHANG; Fabao GAO; Yinghua WU

doi:10.16016/j.2097-0927.202207064

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Value of cardiac magnetic resonance tissue tracking imaging for assessment of early cardiac function in rats with left ventricular remodeling

Basic Medicine | 更新时间：2026-01-09

- Value of cardiac magnetic resonance tissue tracking imaging for assessment of early cardiac function in rats with left ventricular remodeling
- Journal of Army Medical University Vol. 45, Issue 3, Pages: 235-242(2023)
- 作者机构：
  
  1.610072 成都, 成都中医药大学附属医院临床医学院
  2.402460 重庆, 重庆市荣昌区中医院五官科
  3.610041 成都, 四川大学华西医院放射科
- 作者简介：
- 基金信息：
  
  the Key Program of National Natural Science Foundation of China(81930046)
- DOI：10.16016/j.2097-0927.202207064
  CLC： R-332;R331.31;R445.2
- Received：10 July 2022，
  
  Revised：2022-09-15，
  
  Published：15 February 2023
- 稿件说明：
移动端阅览
Haichen LI, Mei LI, Ruijue HUANG, et al. Value of cardiac magnetic resonance tissue tracking imaging for assessment of early cardiac function in rats with left ventricular remodeling[J]. Journal of Army Medical University, 2023, 45(3): 235-242.
DOI：

Haichen LI, Mei LI, Ruijue HUANG, et al. Value of cardiac magnetic resonance tissue tracking imaging for assessment of early cardiac function in rats with left ventricular remodeling[J]. Journal of Army Medical University, 2023, 45(3): 235-242. DOI： 10.16016/j.2097-0927.202207064.

摘要

目的

探讨7.0T心脏磁共振组织追踪成像(cardiac magnetic resonance tissue tracking imaging

CMR-TT)评价异丙肾上腺素(isoproterenol

ISO)诱导的左心室重构早期大鼠心功能的价值。

方法

纳入18只无特定病原体(specific pathogen-free

SPF)级健康雄性SD大鼠

按随机数字表法分为对照组(

=6)和模型组(

=12)。采用连续10 d皮下多点注射ISO溶液10 mg·kg

-1

·d

-1

构建左心室重构大鼠模型。造模结束后

对剩余大鼠即行7.0T CMR电影序列扫描采集数据

后处理软件CVI42.0分析比较两组大鼠左心室常规心功能参数及心肌应变参数差异。酶联免疫吸附实验(enzyme-linked immunosorbent assay

ELISA)检测右心房血清中心肌肌钙蛋白Ⅰ(cardiac troponin Ⅰ

cTn-Ⅰ)及氨基末端脑钠肽前体(N-terminal B-type natriuretic peptide

NT-pro BNP)含量。Pearson相关分析评价左心室射血分数(left ventricular ejection fraction

LVEF)、cTn-Ⅰ、NT-pro BNP与左心室各整体心肌应变参数之间的相关性。

结果

影像学、血清及病理学观测发现

模型组大鼠较正常组左心室心肌肥厚明显

心肌各基底层出现不同程度的损伤

提示心肌收缩功能障碍; 模型组大鼠全心质量、全心质量指数、左心室舒张末期容积(LVEDV)、左心室收缩末期容积(LVESV)、左心室心肌质量(LVM)、左心室舒张末期最大室壁厚度(LVEDTHmax)、左心室重构指数(LVRI)、cTn-Ⅰ、NT-pro BNP均较对照组显著增大(

0.05);模型组大鼠LVEF、左心室整体环向应变(LVGCS)、左心室整体径向应变(LVGRS)、左心室整体纵向应变(LVGLS)、左心室近段径向应变(LVGRS-Mid-cavity)、左心室远段径向应变(LVGRS-Apical)、左心室近段环向应变(LVGCS-Mid-cavity)、左心室远段环向应变(LVGCS-Apical)、左心室基底部纵向应变(LVGLS-Basal)、左心室远段纵向应变(LVGLS-Apical)均较对照组不同程度降低(

0.05)。同时

LVEF、cTn-Ⅰ、NT-pro BNP与左心室各整体心肌应变参数变化均具有一定相关性。

结论

CMR-TT可用于评估早期左心室重构的心功能障碍。

Abstract

Objective

To investigate the value of 7.0T cardiac magnetic resonance tissue tracking imaging (CMR-TT) in evaluation of cardiac function in rats with early left ventricular remodeling induced by isoproterenol (ISO).

Methods

Eighteen male healthy specific pathogen-free (SPF) SD rats were randomly divided into control (

=6) and model group (

=12).The rat model of early left ventricular remodeling was established by subcutaneous multipoint injection of 10 mg·kg

-1

·d

-1

ISO solution for 10 d.After modeling

7.0T CMR cine sequence scans were performed immediately

and the post-processing software CVI42.0 was used to analyze and compare the differences in each left ventricular (LV) function and myocardial strain parameters between the 2 groups of rats.Enzyme-linked immunosorbent assay (ELISA) was performed to detect cardiac troponin Ⅰ(cTn-Ⅰ) and N-terminal B-type natriuretic peptide (NT-pro BNP) levels in right atrial transvenous serum.Pearson correlation analysis was employed to analyze the correlation of left ventricular ejection fraction (LVEF)

cTn-Ⅰ and NT-pro BNP levels with each overall myocardial strain parameter of LV.

Results

The results of imaging

serology and pathology displayed that that the model group showed obvious hypertrophy of the LV myocardium and different damage at each base of the myocardium

resulting in a significant decrease in conventional cardiac function and myocardial strain parameters of LV

which was the symbol of myocardial contractile dysfunction.Compared with the control group

heart mass (HM)

heart mass index (HMI)

left ventricular end-diastolic volume (LVEDV)

left ventricular end-systolic volume (LVESV)

left ventricular myocardial mass (LVM)

left ventricular end-diastolic maximum wall thickness (LVEDTHmax)

and left ventricular remodeling index (LVRI) were significantly greater in the rats of the model group (

0.05).LVEF

left ventricular global circumferential strain (LVGCS)

left ventricular global radial strain (LVGRS)

left ventricular global longitudinal strain (LVGLS)

LVGRS-

Mid-cavity

LVGRS-Apical

LVGCS-Mid-cavity

LVGCS-Apical

LVGLS-Basal

and LVGLS-Apical decreased in different degrees (

0.05).The changes in LVEF and cTn-Ⅰ and NT-pro BNP levels were all correlated with the changes in each overall LV myocardial strain parameter.

Conclusion

CMR-TT can be used to assess cardiac dysfunction in early left ventricular remodeling.

关键词

Keywords

references

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