Advances and thinking for early treatment of war wound and traumatic shock

Liangming LIU

doi:10.16016/j.2097-0927.202205151

您当前的位置：

首页 >

文章列表页 >

Advances and thinking for early treatment of war wound and traumatic shock

Monographic Reports: Treatment of war wound and traumatic shock | 更新时间：2026-01-09

- Advances and thinking for early treatment of war wound and traumatic shock
- Journal of Army Medical University Vol. 44, Issue 20, Pages: 2025-2029(2022)
- 作者机构：
  
  400042 重庆，陆军特色医学中心战伤休克与输血研究室，创伤、烧伤与复合伤国家重点实验室
- 作者简介：
- 基金信息：
- DOI：10.16016/j.2097-0927.202205151
  CLC： R605.971;R826.1
- Received：27 May 2022，
  
  Revised：2022-06-29，
  
  Published：30 October 2022
- 稿件说明：
移动端阅览
Liangming LIU. Advances and thinking for early treatment of war wound and traumatic shock[J]. Journal of Army Medical University, 2022, 44(20): 2025-2029.
DOI：

Liangming LIU. Advances and thinking for early treatment of war wound and traumatic shock[J]. Journal of Army Medical University, 2022, 44(20): 2025-2029. DOI： 10.16016/j.2097-0927.202205151.

摘要

战创伤休克是战创伤患者早期死亡的重要原因。近年来针对战创伤休克早期救治，国际上提出了很多新的理念和技术

如限制性液体复苏、允许性低压复苏和延长黄金救治时间窗等。基于我军卫勤保障和战伤救治任务，本文重点分析高原高寒和海战伤休克的特点，并从线粒体功能保护角度提出的抗休克新措施；探讨脓毒症后肠道和血管屏障功能发生机制及新的保护措施，以及苹果酸新型复苏液体；同时，从新型复苏液体研究、新的救治靶点寻找讨论了战创伤休克救治研究趋势和方向。

Abstract

Traumatic shock is a main cause for early death of war wound and trauma. As for the early treatment of war wound and traumatic shock

many new concepts and techniques have been raised in recent years

such as limited fluid resuscitation

permissive fluid resuscitation and expanding golden hour care window. Based on the needs of our medical support and combat casualty care

the features and new treatment measures of war wound and traumatic shock at high altitude and marine

we discuss the new mechanisms and treatments of intestinal and vascular barrier function after sepsis and the new anti-shock fluids-malic acid fluid

and bring forward to the future research trends based on the new types of resuscitative fluid and new targets for war wound and traumatic shock.

关键词

Keywords

references

BOGERT J N, HARVIN J A, COTTON B A. Damage control resuscitation[J]. J Intensive Care Med, 2016, 31(3): 177-186. DOI: 10.1177/0885066614558018.

ORDOÑEZ C A, PARRA M W, SERNA J J, et al . Damage control resuscitation: REBOA as the new fourth pillar[J ] . Colomb Med (Cali), 2020, 51(4): e4014353. DOI: 10.25100/cm.v51i4.4353.

BRIDWELL R E, SCHAFFRINNA A M, LONG B, et al . Damage control resuscitation: a narrative review of goals, techniques, and components[J ] . Med J (Ft Sam Houst Tex), 2021(04/05/06): 20-31.

OWATTANAPANICH N, CHITTAWATANARAT K, BENYAKORN T, et al . Risks and benefits of hypotensive resuscitation in patients with traumatic hemorrhagic shock: a meta-analysis[J ] . Scand J Trauma Resusc Emerg Med, 2018, 26(1): 107. DOI: 10.1186/s13049-018-0572-4.

WOODWARD L, ALSABRI M. Permissive hypotension vs. conventional resuscitation in patients with trauma or hemorrhagic shock: a review[J]. Cureus, 2021, 13(7): e16487. DOI: 10.7759/cureus.16487.

HO K H, TARNG Y W, CHOU Y P, et al . permissive hypotensive resuscitation in patients with traumatic hemorrhagic shock[J ] . Scand J Trauma Resusc Emerg Med, 2019, 27(1): 14. DOI: 10.1186/s13049-019-0595-5.

MARSDEN N J, TUMA F. Polytraumatized patient[M]//StatPearls[Internet]. Treasure Island (FL): StatPearls Publishing, 2021. PMID: 32119313.

TISHERMAN S, O'CONNOR J. Can hypothermia save dying military trauma patients?[J]. J R Army Med Corps, 2018, 164(3): 140-141. DOI: 10.1136/jramc-2017-000837.

ZHAO J X, YOU G X, YIN Y J, et al . Acute high-altitude exposure shortens survival after uncontrolled hemorrhagic shock in rats[J ] . J Surg Res, 2018, 226: 150-156. DOI: 10.1016/j.jss.2018.01.028.

ZHAO J X, YOU G X, WANG B, et al . Hypotensive resuscitation with hypertonic saline dextran improves survival in a rat model of hemorrhagic shock at high altitude[J ] . Shock, 2017, 48(2): 196-200. DOI: 10.1097/SHK.0000000000000827.

ZHOU Q Q, LUO Y J, LIU F Y, et al . Resuscitative effect of hyperoxia fluid on high-altitude hemorrhagic shock in rats and antishock mechanisms[J ] . Cell Biochem Biophys, 2012, 62(2): 343-352. DOI: 10.1007/s12013-011-9316-z.

SULKSHANE P, RAM J, THAKUR A, et al . Ubiquitination and receptor-mediated mitophagy converge to eliminate oxidation-damaged mitochondria during hypoxia[J ] . Redox Biol, 2021, 45: 102047. DOI: 10.1016/j.redox.2021.102047.

吴跃、朱娱、周远群, 等. 线粒体分裂抑制剂Mdivi-1对高原战创伤休克大鼠的保护作用[J]. 陆军军医大学学报, 2022, 44(20): 2030-2036. DOI: 10.16016/j.2097-0927.202205040.

WU Y, ZHU Y, ZHOU Y Q, et al . Protective effects of mitochondrial fission inhibitor, mdivi-1, on traumatic shock rats at high altitude[J ] . J Army Med Univ, 2022, 44(20): 2030-2036. DOI: 10.16016/j.2097-0927.202205040.

LIU K L, YU X J, SUN T Z, et al . Effects of seawater immersion on open traumatic brain injury in rabbit model[J ] . Brain Res, 2020, 1743: 146903. DOI: 10.1016/j.brainres.2020.146903.

邓皓月, 朱娱, 吴跃, 等. 21 ℃海水浸泡对失血休克大鼠主要器官功能的影响[J]. 陆军军医大学学报, 2022, 44(20): 2048-2053. DOI: 10.16016/j.2097-0927.202205038.

DENG Haoyue, ZHU Yu, WU Yue, et al . Effects of seawater immersion at 21 ℃ on major organ functions in rats with hemorrhagic shock[J ] . J Army Med Univ, 2022, 44(20): 2048-2053. DOI: 10.16016/j.2097-0927.202205038.

SUN S L, DUAN Z H, WANG X Y, et al . Neutrophil extracellular traps impair intestinal barrier functions in Sepsis by regulating TLR9-mediated endoplasmic Reticulum stress pathway[J ] . Cell Death Dis, 2021, 12(6): 606. DOI: 10.1038/s41419-021-03896-1.

LIU Y J, TANG B, WANG F C, et al . Parthenolide ameliorates colon inflammation through regulating Treg/Th17 balance in a gut microbiota-dependent manner[J ] . Theranostics, 2020, 10(12): 5225-5241. DOI: 10.7150/thno.43716.

郭宁珂, 佘汉, 谭磊, 等. 小白菊内酯对脓毒症大鼠肠屏障功能的保护作用[J]. 陆军军医大学学报, 2022, 44(20): 2068-2074. DOI: 10.16016/j.2097-0927.202205042.

GUO N K, SHE H, TAN L, et al . Protective effects of parthenolide on intestinal barrier function in septic rats[J ] . J Army Med Univ, 2022, 44(20): 2068-2074. DOI: 10.16016/j.2097-0927.202205042.

DARDALAS I, STAMOULA E, RIGOPOULOS P, et al . Dexmedetomidine effects in different experimental Sepsis in vivo models[J ] . Eur J Pharmacol, 2019, 856: 172401. DOI: 10.1016/j.ejphar.2019.05.030..

周世洁, 王莉, 刘良明, 等. 右美托咪定对脓毒症大鼠肠道屏障功能的保护作用[J]. 陆军军医大学学报, 2022, 44(20): 2061-2067. DOI: 10.16016/j.2097-0927.202205043.

ZHOU S J,WANG L, LIU L M, et al . Protective effect of dexmedetomidine on intestinal barrier function in septic rats[J ] . J Army Med Univ, 2022, 44(20): 2061-2067. DOI: 10.16016/j.2097-0927.202205043.

MÄE M A, HE L Q, NORDLING S, et al . Single-cell analysis of blood-brain barrier response to pericyte loss[J ] . Circ Res, 2021, 128(4): e46-e62. DOI: 10.1161/CIRCRESAHA.120.317473.

ZHOU H N, ZHENG D Y, WANG H C, et al . The protective effects of pericyte-derived microvesicles on vascular endothelial functions via CTGF delivery in Sepsis[J ] . Cell Commun Signal, 2021, 19(1): 115. DOI: 10.1186/s12964-021-00795-y.

刘奕言, 张紫森, 包代琴, 等. 抑制周细胞铁死亡对脓毒症大鼠肺血管屏障功能的保护作用[J]. 陆军军医大学学报, 44(20): 2037-2047. DOI: 10.16016/j.2097-0927.202205044.

LIU Y Y, ZHANG Z S, BAO D Q, et al . protective effects of inhibiting pericyte ferroptosis on pulmonary vascular barrier function in septic rats[J ] . J Army Med Univ, 44(20): 2037-2047. DOI: 10.16016/j.2097-0927.2022050 44.

CURRAN J D, MAJOR P, TANG K, et al . Comparison of balanced crystalloid solutions: a systematic review and meta-analysis of randomized controlled trials[J ] . Crit Care Explor, 2021, 3(5): e0398. DOI: 10.1097/CCE.0000000000000398.

谭磊, 佘汉, 郭宁珂, 等. 瑞咯啶对脓毒症大鼠心肌损伤的保护作用[J]. 陆军军医大学学报, 44(20): 2054-2060. DOI: 10.16016/j.2097-0927.202205039.

TAN L, SHE H, GUO N K, et al . Protective effects of sterofundin on myocardial injury in septic rats[J ] . J Army Med Univ, 44(20): 2054-2060. DOI: 10.16016/j.2097-0927.202205039.

CASTRO-FARIA-NETO H C. What's new in shock, October 2021?[J]. Shock, 2021, 56(4): 479-483. DOI: 10.1097/SHK.0000000000001857.

FONT M D, THYAGARAJAN B, KHANNA A K. Sepsis and septic shock - Basics of diagnosis, pathophysiology and clinical decision making[J]. Med Clin North Am, 2020, 104(4): 573-585. DOI: 10.1016/j.mcna.2020.02.011.

KUO K, PALMER L. Pathophysiology of hemorrhagic shock[J]. J Vet Emerg Crit Care (San Antonio), 2022, 32(S1): 22-31. DOI: 10.1111/vec.13126.

FEICHTINGER S, DE MAN A, DALIA A A, et al . Sepsis and resuscitation: the importance of time[J ] . Crit Care Med, 2022, 50(6): e615-e616. DOI: 10.1097/ccm.0000000000005494.

Views

下载量

CSCD

Alert me when the article has been cited

提交

Tools

Publicity Resources

Beneficial effects of a new hemoglobin substitute on functions of vital organs in traumatic hemorrhagic shock rats

Effects of seawater immersion at 21 ℃ on major organ functions in rats with hemorrhagic shock

Protective effects of mitochondrial fission inhibitor, Mdivi-1, on traumatic shock rats at high altitude

Fluid resuscitation with guidance of pulse pressure variability measured by continuous non-invasive arterial pressure monitor in postoperative hypovolemic patients: a prospective randomized controlled trial

Role of activated dynamin-related protein 1-mediated glutathione metabolism in regulation of mitochondrial dysfunction after hemorrhagic shock

Related Author

Tao LI

Liangming LIU

Xinming XIANG

Xiaoyong PENG

Jie ZHANG

Yue WU

Kunlun TIAN

Yu ZHU

Related Institution

State Key Laboratory of Trauma, Burns and Combined Injury, Department 2, Institute of Surgery Research, Third Affiliated Hospital, Army Medical University (Third Military Medical University)

Fourth Department of Intensive Care Unit, Fujian Provincial Hospital, Shengli Clinical Medical College of Fujian Medical University

Department of Emergency, Fujian Provincial Key Laboratory of Emergency Medicine, Fujian Provincial Hospital, Shengli Clinical Medical College of Fujian Medical University

State Key Laboratory of Trauma, Burns and Combined Injury, Department of War Wound Shock and Blood Transfusion, Institute of Surgery Research, Army Medical University (Third Military Medical University)

⁰