Effects of controlled hypotension induced by sodium nitroprusside on regional cerebral blood flow and oxygenation in pigs

Dukun ZUO; Yang LI; Taotao PENG; Huawei LIU; Guiying YANG; Zhenxin DUAN; Hong LI

doi:10.16016/j.2097-0927.202205113

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Effects of controlled hypotension induced by sodium nitroprusside on regional cerebral blood flow and oxygenation in pigs

Basic Medicine | 更新时间：2026-01-09

- Effects of controlled hypotension induced by sodium nitroprusside on regional cerebral blood flow and oxygenation in pigs
- Journal of Army Medical University Vol. 44, Issue 17, Pages: 1687-1693(2022)
- 作者机构：
  
  400037 重庆，陆军军医大学(第三军医大学)第二附属医院麻醉科
- 作者简介：
- 基金信息：
  
  the National Key Research and Development Program(2018YFC0117200)
- DOI：10.16016/j.2097-0927.202205113
  CLC： R331.37;R965;R972.4
- Received：19 May 2022，
  
  Revised：2022-07-15，
  
  Published：15 September 2022
- 稿件说明：
移动端阅览
Dukun ZUO, Yang LI, Taotao PENG, et al. Effects of controlled hypotension induced by sodium nitroprusside on regional cerebral blood flow and oxygenation in pigs[J]. Journal of Army Medical University, 2022, 44(17): 1687-1693.
DOI：

Dukun ZUO, Yang LI, Taotao PENG, et al. Effects of controlled hypotension induced by sodium nitroprusside on regional cerebral blood flow and oxygenation in pigs[J]. Journal of Army Medical University, 2022, 44(17): 1687-1693. DOI： 10.16016/j.2097-0927.202205113.

摘要

目的

探讨硝普钠控制性降压对猪脑局部血流和氧合的影响。

方法

健康雌性长白猪6头，4~6月龄，体重22~25 kg。在七氟醚麻醉下使用硝普钠进行控制性降压(分别较平均动脉压基础值降低20%、30%、50%，分别对应轻、中、重度降压)，并使用氧立见(oxygen to see

O2C)直接测量猪脑前额部局部脑血流(regional cerebral blood flow

rCBF)以及局部脑组织氧饱和度(regional cerebral oxygen saturation

rSO

)。记录不同平均动脉压(mean arterial pr

essure

MAP)下的rCBF、rSO

、局部血红蛋白(regional cerebral haemoglobin

rHb)、心率(heart rate

HR)、外周血氧饱和度(peripheral oxygen saturation

SpO

)以及脑缺氧事件的发生情况。

结果

在整个降压过程中rCBF与MAP(

=0.793)和rSO

(

=0.843)均显著相关。rSO

与MAP、rHb和rCBF呈线性相关(

=0.853，

0.05)，且与rSO

的线性相关程度依次为rHb

MAP

rCBF。轻度降压时，rCBF和rSO

分别较基线值增加约7.4%(

0.05)和2.5%(

0.05)，以rCBF增加更显著；而中度降压时，rCBF较基线值下降0.9%(

0.05)，而rSO

较基线值下降约5.8%(

0.05)；重度降压时，rCBF和rSO

较基线值分别下降约7.6%(

0.05)和12.1%(

0.05)。轻至重度降压时均未出现脑缺氧事件。停药后5 min至15 min

rCBF与rSO

均较基线值增加，分别增加8.4%(

0.05)和3.7%(

0.05)。

结论

使用硝普钠行控制性降压对维持大脑灌注、脑氧合有利，但轻度降压可增加脑血流，对颅内压已增高患者不利。

Abstract

Objective

To investigate the effects of controlled hypotension induced by sodium nitroprusside on regional cerebral blood flow and oxygenation in pigs.

Methods

Six healthy female Landrace pigs (aged 4~6 months

weighing 22~25 kg) were included in this study. Sodium nitroprusside was used for controlled hypotension under sevoflurane anesthesia (20%

30% and 50% lower than the baseline of mean arterial pressure or mean arterial pressure (MAP)

corresponding to mild

moderate and severe hypotension

respectively). Oxygen to see (O2C)

a monitoring instrument

was used to measure regional cerebral blood flow (rCBF) and regional cerebral oxygen saturation (rSO

). rCBF

rSO

regional cerebral haemoglobin (rHb)

heart rate (HR)

peripheral oxygen saturation (SpO

) and incidence of cerebral hypoxia events were recorded under different MAP.

Results

rCBF was significantly correlated with MAP (

=0.793) and also obviously correlated with rSO

(

=0.843) in the whole hypotension process. rSO

had a linear correlation with rHb

MAP and rCBF (

=0.853

0.05)

respectively. And the order of their linear correlation with rSO

is rHb

MAP

rCBF. During mild hypotension

rCBF and rSO

were increased by 7.4%(

0.05) and 2.5%(

0.05)

respectively compared with the baseline

and the increase of rCBF was more remarkable. During moderate hypotension

compared with the baseline

rCBF was decreased by 0.9% (

0.05)

while rSO

was decreased by 5.8% (

0.05). During severe hypotension

rCBF and rSO

were decreased by 7.6% (

0.05) and 12.1% (

0.05) respectively

and there was no cerebral hypoxia event during mild to severe hypotension. From 5 to 15 min after drug withdrawal

both rCBF and rSO

were increased by 8.4% and 3.7%

respectively when compared with the baseline (both

0.05).

Conclusion

Controlled hypotension with sodium nitroprusside is beneficial to maintain cerebral perfusion and cerebral oxygenation

but mild hypotension can cause an increase in cerebral blood flow

which is disadvantageous to patients with increased intracranial pressure.

关键词

Keywords

references

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