Current status and prospect for development of COVID-19 vaccine adjuvants

Haibo LI; Hao CHENG

doi:10.16016/j.2097-0927.202205047

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Current status and prospect for development of COVID-19 vaccine adjuvants

Expert Review | 更新时间：2026-01-09

- Current status and prospect for development of COVID-19 vaccine adjuvants
- Journal of Army Medical University Vol. 44, Issue 23, Pages: 2353-2359(2022)
- 作者机构：
  
  400038 重庆，陆军军医大学(第三军医大学)药学与检验医学系微生物与生化药学教研室，国家免疫生物制品工程技术研究中心
- 作者简介：
- 基金信息：
  
  the General Program of National Natural Science Foundation of China(32270988);the Key Project of Natural Science Foundation of Chongqing(cstc2020jcyj-zdxmX0027)
- DOI：10.16016/j.2097-0927.202205047
  CLC： R373.1;R392.7
- Received：10 May 2022，
  
  Revised：2022-06-24，
  
  Published：15 December 2022
- 稿件说明：
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Haibo LI, Hao CHENG. Current status and prospect for development of COVID-19 vaccine adjuvants[J]. Journal of Army Medical University, 2022, 44(23): 2353-2359.
DOI：

Haibo LI, Hao CHENG. Current status and prospect for development of COVID-19 vaccine adjuvants[J]. Journal of Army Medical University, 2022, 44(23): 2353-2359. DOI： 10.16016/j.2097-0927.202205047.

摘要

疫苗是预防新冠病毒感染最经济和最有效的手段。佐剂能增强抗原特异性免疫应答，减少抗原剂量和接种次数，重塑适应性免疫反应，对提高新冠病毒疫苗的保护效果至关重要。本文评述了已经授权紧急使用或正在开展临床试验的新冠病毒疫苗所用佐剂及其作用机制和优缺点，分析了新冠病毒疫苗研发中应用佐剂须考虑的问题，并对新冠病毒疫苗佐剂的未来研究方向进行了展望：①针对免疫功能不全人群的佐剂；②增强T细胞应答的佐剂；③新型黏膜免疫佐剂；④复合佐剂的合理设计。

Abstract

Vaccines are the most economical and effective means to protect against SARS-CoV-2 infection. Adjuvants are able to enhance antigen-specific immune responses

reduce antigen doses and vaccination times

and reshape adaptive immune responses

which are crucial to improving the protective efficacy of vaccines. In this article

we review the mechanisms and advantages/disadvantages of the adjuvants used in COVID-19 vaccines that have been authorized for emergency use or are undergoing clinical trials around the world

and analyze the issues that must be considered in the application of adjuvants to COVID-19 vaccines. In addition

we put forward suggestions for future research strategies for COVID-19 vaccine adjuvants: ① adjuvants for immunocompromised people

② adjuvants for inducing T cell responses

③ novel mucosal immune adjuvants

and ④ the rational design of combination adjuvant.

关键词

Keywords

references

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