Value of energy spectrum CT volume quantitative parameters in differentiating pathological types of colorectal cancer

Xiaofeng LI; Yuxiang ZHUANG; Langzhou FU; Qiao LIU; Daiquan ZHOU; Lianqin KUANG; Yan ZENG

doi:10.16016/j.2097-0927.202204001

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Value of energy spectrum CT volume quantitative parameters in differentiating pathological types of colorectal cancer

Clinical Medicine | 更新时间：2026-01-09

- Value of energy spectrum CT volume quantitative parameters in differentiating pathological types of colorectal cancer
- Journal of Army Medical University Vol. 44, Issue 18, Pages: 1881-1886(2022)
- 作者机构：
  
  401120 重庆，重庆医科大学附属第三医院放射科
- 作者简介：
- 基金信息：
- DOI：10.16016/j.2097-0927.202204001
  CLC： R735.35;R814.3;R814.42
- Received：01 April 2022，
  
  Revised：2022-05-06，
  
  Published：30 September 2022
- 稿件说明：
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Xiaofeng LI, Yuxiang ZHUANG, Langzhou FU, et al. Value of energy spectrum CT volume quantitative parameters in differentiating pathological types of colorectal cancer[J]. Journal of Army Medical University, 2022, 44(18): 1881-1886.
DOI：

Xiaofeng LI, Yuxiang ZHUANG, Langzhou FU, et al. Value of energy spectrum CT volume quantitative parameters in differentiating pathological types of colorectal cancer[J]. Journal of Army Medical University, 2022, 44(18): 1881-1886. DOI： 10.16016/j.2097-0927.202204001.

摘要

目的

探讨能谱CT容积定量参数对鉴别结直肠癌病理类型的临床价值。

方法

回顾性分析2019年1月至2021年11月在本院经病理证实的66例结直肠癌患者的临床和影像学资料，其中黏液腺癌16例，管状腺癌50例，采用不同的感兴趣区域(region of interest

ROI)获取方法测得肿瘤的容积参数和二维参数，包括碘(水)浓度、水(碘)浓度、有效原子序数，并计算出标准化碘(水)浓度(normalized iodine concentration，NIC)。采用

检验或Mann-Whitney

检验进行组间比较，对有统计学意义的参数运用ROC曲线评价其对结直肠癌病理

类型的诊断效能。

结果

能谱CT容积参数中，动脉期和静脉期的碘(水)浓度、NIC、有效原子序数组间差异均具有统计学意义(

＜0.01)；黏液腺癌的碘(水)浓度、NIC、有效原子序数均低于管状腺癌。而在二维参数中，仅静脉期的碘(水)浓度、NIC、有效原子序数组间差异具有统计学意义(

＜0.05)。黏液腺癌的容积碘(水)浓度和NIC低于相应二维参数。ROC曲线显示容积参数的曲线下面积均高于二维参数，其中动脉期容积NIC的诊断效能最高，其敏感度为82.0%，特异度为87.5%。

结论

能谱CT容积定量参数对鉴别结直肠黏液腺癌和管状腺癌较二维参数可能具有更大的潜在临床价值。

Abstract

Objective

To investigate the clinical value of energy spectrum CT volume quantitative parameters in differentiating pathological types of colorectal cancer.

Methods

The clinical and imaging data of 66 patients (16 cases of mucinous adenocarcinoma and 50 cases of tubular adenocarcinoma) with colorectal cancer confirmed by pathology in our hospital from January 2019 to November 2021 were collected and retrospectively analyzed. The volume parameters and two-dimensional parameters of the tumor

including iodine (water) concentration

water (iodine) concentration and effective atomic number

were measured by different methods of region of interest (ROI) acquisition

and normalized iodine (water) concentration (NIC) was calculated. Student's

test or Mann-Whitney

test was used for comparison between groups

and receiver operating characteristic (ROC) curve was drawn to evaluate the diagnostic efficacy of statistically significant parameters for pathological types of colorectal cancer.

Results

In terms of energy spectrum volume parameters

iodine (water) concentration

NIC and Eff-Z in arterial and venous phases were significantly different (

0.01). The iodine (water) concentration

NIC and Eff-Z of mucinous adenocarcinoma were lower than those of tubular adenocarcinoma. However

in the two-dimensional parameters

only iodine (water) concentration

NIC and Eff-Z in venous phase had significant differences among grou

ps (

0.05). The volumetric iodine (water) concentration and NIC in mucinous adenocarcinoma were lower than corresponding two-dimensional parameters. ROC curve showed that the area under the curve of energy spectrum volume parameters was higher than that of two-dimensional parameters. Among them

arterial volume NIC had the highest diagnostic efficiency

with a sensitivity of 82.0% and specificity of 87.5%.

Conclusion

The quantitative parameters of CT volume of energy spectrum may have greater potential clinical value in differentiating mucinous colorectal adenocarcinoma from tubular adenocarcinoma than two-dimensional parameters.

关键词

Keywords

references

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