Quality of life and its influencing factors in patients with atrial fibrillation

Jiaxue MA; Qin ZHANG; Xiaojuan ZENG; Na WU; Zhiquan YUAN; Chengying LI; Long WU; Yanxiu CHEN; Xiang XU; Shifei TONG; Yafei LI; Zhihui ZHANG; Li ZHONG

doi:10.16016/j.2097-0927.202203248

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Quality of life and its influencing factors in patients with atrial fibrillation

Clinical Medicine | 更新时间：2026-01-09

- Quality of life and its influencing factors in patients with atrial fibrillation
- Journal of Army Medical University Vol. 44, Issue 18, Pages: 1835-1844(2022)
- 作者机构：
  
  1.401120 重庆，重庆医科大学附属第三医院心血管内科
  2.400038 重庆，陆军军医大学(第三军医大学)：军事预防医学系军队流行病学教研室
  3.400038 重庆，陆军军医大学(第三军医大学)：第一附属医院心血管内科
- 作者简介：
- 基金信息：
  
  the General Program of National Natural Science Foundation of China(82073649)
- DOI：10.16016/j.2097-0927.202203248
  CLC： R195.4;R492;R541.75
- Received：28 March 2022，
  
  Revised：2022-05-09，
  
  Published：30 September 2022
- 稿件说明：
移动端阅览
Jiaxue MA, Qin ZHANG, Xiaojuan ZENG, et al. Quality of life and its influencing factors in patients with atrial fibrillation[J]. Journal of Army Medical University, 2022, 44(18): 1835-1844.
DOI：

Jiaxue MA, Qin ZHANG, Xiaojuan ZENG, et al. Quality of life and its influencing factors in patients with atrial fibrillation[J]. Journal of Army Medical University, 2022, 44(18): 1835-1844. DOI： 10.16016/j.2097-0927.202203248.

摘要

目的

调查心房颤动(简称房颤)患者的生活质量，探讨影响房颤患者生活质量的相关因素。

方法

采用房颤患者特异性汉化版房颤生活质量量表(Atrial Fibrillation Effect on Quality-of-Life，AFEQT)，对2016年6月至2021年3月在两所三甲医院心血管内科就诊的非瓣膜性房颤患者进行生活质量调查，采用多因素logistic回归分析与房颤患者生活质量相关的因素。

结果

共调查321例房颤患者。房颤患者生活质量的总分中位数

(四分位数

，

)为79.86(70.25，89.81)。针对生活质量不同维度的多因素logistic回归分析发现，吸烟史、升高的凝血酶时间(thrombin time，TT)、总蛋白(total protein，TP)和D-二聚体(D-dimer)水平是症状维度的危险因素，而有甲状腺功能障碍史则是保护因素；日常活动维度的危险因素包括高龄(≥65岁)、高血压病史、脑卒中病史、华法林药物史以及升高的TT，而饮酒可能是保护因素；有高血压病史，华法林、他汀药物史以及单核细胞(monocytes，MONO)水平和凝血酶原时间(prothrombin time，PT)升高的房颤患者的治疗担心维度评分显著下降，而活化部分凝血活酶时间比值(activated partial thromboplastin time ratio，APTT-ratio)升高是治疗担心维度评分的保护因素；延长的TT是治疗满意维度评分下降的危险因素，而有新型口服抗凝(novel oral anticoagulants，NOACs)药物史以及APTT-ratio升高是治疗满意维度评分下降的保护因素；生活质量总分下降的危险因素包括高龄(≥75岁)、脑卒中史、华法林和他汀药物史以及D-dimer水平，而饮酒以及较高的中性粒细胞(neutrophil，NEU)水平则是其保护因素。

结论

高龄(≥65岁)、吸烟史、华法林和他汀类药物史、高血压和脑卒中病史、升高的MONO、TP、TT、PT以及D-dimer水平等多种因素影响房颤患者生活质量的不同维度。

Abstract

Objective

To explore the quality of life and its influencing factors in patients with atrial fibrillation (AF).

Methods

The Chinese Atrial Fibrillation Effect on Quality-of-Life(AFEQT) questionnaire was used to investigate the quality of life in AF patients who had been treated in the Department of Cardiovascular Diseases of 2 tertiary Class A hospitals from June 2016 to March 2021. Multivariate logistic regression model was used to analyze the factors related to the quality of life in the patients.

Results

A total of 321 AF patients were investigated. The median of total score for quality of life was 79.86 (interquartile range: 70.25

89.81) in the AF patients. Multivariate logistic regression analysis on different dimensions of quality of life found that smoking history

elevated thrombin time (TT)

total protein and D-dimer levels were risk factors in the symptom dimension

while a history of thyroid dysfunction was a protective factor; risk factors in the daily activity dimension included advanced age (≥65 years)

hypertension history

stroke history

history of warfarin use

and prolonged TT

while alcohol consumption may be protective factors; the patients with history of hypertension

warfarin and statin use

and elevated monocyte (MONO) count and prolonged prothrombin time (PT) had significantly lower scores in the dimension of treatment of worried

while an activated partial thromboplastin time ratio (APTT-ratio) was a protective factor in the treatment of the worry score; prolonged TT was a risk factor for decreased treatment satisfaction scores; a history of novel oral anticoagulants (NOACs) and elevated APTT-ratio were protective factors for decreased treatment satisfaction scores; risk factors for decreased overall quality of life scores included advanced age (≥75 years)

history of stroke

warfarin and statin use

and D-dimer level

while alcohol consumption and higher neutrophil count were protective factors.

Conclusion

Advanced age (≥65 years)

smoking history

warfarin and statin history

hypertension

stroke history

elevated MONO

and D-dimer level affect quality of life in AF patients in different dimensions.

关键词

Keywords

references

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