Reference range of corpus callosum volume based on MRI data in typical development preschool children

Yun ZHANG; Longlun WANG; Jinhua CAI; Ke ZHANG; Bin QIN

doi:10.16016/j.2097-0927.202203010

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Reference range of corpus callosum volume based on MRI data in typical development preschool children

Clinical Medicine | 更新时间：2026-01-09

- Reference range of corpus callosum volume based on MRI data in typical development preschool children
- Journal of Army Medical University Vol. 44, Issue 17, Pages: 1770-1777(2022)
- 作者机构：
  
  1.400014 重庆，重庆医科大学附属儿童医院放射科，国家儿童健康与疾病临床医学研究中心，儿童发育疾病研究教育部重点实验室，儿童营养与健康重庆市重点实验室
  2.400016 重庆，重庆医科大学医学数据研究院
- 作者简介：
- 基金信息：
  
  the Smart Medicine Project of Chongqing Medical University(ZHYX202030)
- DOI：10.16016/j.2097-0927.202203010
  CLC： R322.81;R339.31;R445.2
- Received：02 March 2022，
  
  Revised：2022-03-22，
  
  Published：15 September 2022
- 稿件说明：
移动端阅览
Yun ZHANG, Longlun WANG, Jinhua CAI, et al. Reference range of corpus callosum volume based on MRI data in typical development preschool children[J]. Journal of Army Medical University, 2022, 44(17): 1770-1777.
DOI：

Yun ZHANG, Longlun WANG, Jinhua CAI, et al. Reference range of corpus callosum volume based on MRI data in typical development preschool children[J]. Journal of Army Medical University, 2022, 44(17): 1770-1777. DOI： 10.16016/j.2097-0927.202203010.

摘要

目的

利用正常志愿者儿童核磁共振(magnetic resonance imaging，MRI)数据，探索正常学龄前儿童各年龄段、不同性别胼胝体(corpus callosum，CC)体积变化的特征。

方法

于2018年3月至2019年3月在重庆市公开招募2~6岁正常志愿者儿童，依据标准纳入89名儿童，其中男49例，女40例。于我科完成脑部MRI的3DT1序列薄层扫描和Gesell发育测试，对不同性别、不同年龄段学龄前儿童的胼胝体体积参考范围进行统计描述；用FreeSurfer软件自动提取CC并等分为5个亚区，利用SPSS 22.0软件按性别及年龄对CC及其各个亚区体积进行数据分析。

结果

学龄前儿童CC各亚区的体积与年龄相关性结果显示：胼胝体后部(posterior corpus callosum，PCC)(

= 0.250)、胼胝体中后部(middle posterior corpus callosum，PMCC)(

=0.450)、胼胝体中部(middle corpus callosum，MCC)(

=0.344)、胼胝体前中部(anterior middle corpus callosum，AMCC)(

=0.257)及胼胝体总体积(total corpus callosum，TCC)(

=0.373)与年龄呈正相关性(

0.05)，而胼胝体前部(anterior corpus callosum，ACC)体积与年龄则未显示相关性(

0.155，

=0.148)。依据年龄、性别对比儿童CC各亚区体积差异结果显示：MCC的体积在各年龄段、不同性别的差异均无统计学意义(

0.05)；而PCC、PMCC、AMCC、ACC及TCC的体积在部分年龄段、不同性别的差异存在统计学意义(

0.05)。

结论

ACC在2岁已经相对比较稳定，而胼胝体的其他4个亚区在2~6岁仍随年龄的增长而逐步发育。

Abstract

Objective

To investigate the change profiles in the volume of the corpus callosum (CC) among typical development preschool children of different ages and sexes based on the magnetic resonance imaging (MRI) data from normal volunteers.

Methods

Typical development volunteer children aged 2~6 years were recruited openly in Chongqing during March 2018 and March 2019

and finally 89 children (49 males and 40 females) were included according to the criteria. 3DT1 serial thin-layer scans of brain MRI and Gesell Developmental Scale tests were completed in our radiological department. The CC data were automatically extracted and divided into 5 sub-regions using FREESURFER software. SPSS 22.0 Software was used to statistically analyze the CC data and its individual sub-region volumes by genders and ages in order to describe the reference range of CC volumes in preschool children of different sexes and ages (taking 95%

Results

The volume of each CC sub-region was positively correlated with age (

0.05)

including: posterior corpus callosum (PCC) (

=0.250)

middle posterior corpus callosum (PMCC) (

=0.450)

middle corpus callosum (MCC) (

=0.344)

anterior middle corpus callosum (AMCC) (

=0.257)

and total corpus callosum (TCC) (

=0.373)

while no such correlation was found between anterior corpus callosum (ACC) volume and age (

=0.155

=0.148). No statistically significant difference was seen in MCC volume by age and sex (

0.05)

and statistically significant differences in the volume of PCC

PMCC

AMCC

ACC and TCC were found among different ages and sexes (

0.05).

Conclusion

The ACC is already relatively stable at 2 years of age

while the other 4 CC sub-regions continue to develop progressively with age from 2 to 6 years.

关键词

Keywords

references

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