Dynamic analysis of serum markers of HBV in 302 infants of pregnant women with HBV infection

Jing WANG; Yan ZHU; Zhongwei LIU; Huimin LIU; Shilian LI; Yi WU; Qing MAO

doi:10.16016/j.2097-0927.202202052

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Dynamic analysis of serum markers of HBV in 302 infants of pregnant women with HBV infection

Clinical Medicine | 更新时间：2026-01-09

- Dynamic analysis of serum markers of HBV in 302 infants of pregnant women with HBV infection
- Journal of Army Medical University Vol. 44, Issue 8, Pages: 797-804(2022)
- 作者机构：
  
  400038 重庆，陆军军军医大学(第三军医大学)第一附属医院全军感染病研究所，感染病研究重庆市重点实验室
- 作者简介：
- 基金信息：
  
  the Joint Medical Scientific Research Project of Chongqing Science and Technology Committee and Chongqing Health Committee(2018MSXM011)
- DOI：10.16016/j.2097-0927.202202052
  CLC： R373.21;R446.62;R725.1
- Received：24 February 2022，
  
  Revised：2022-03-01，
  
  Published：30 April 2022
- 稿件说明：
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Jing WANG, Yan ZHU, Zhongwei LIU, et al. Dynamic analysis of serum markers of HBV in 302 infants of pregnant women with HBV infection[J]. Journal of Army Medical University, 2022, 44(8): 797-804.
DOI：

Jing WANG, Yan ZHU, Zhongwei LIU, et al. Dynamic analysis of serum markers of HBV in 302 infants of pregnant women with HBV infection[J]. Journal of Army Medical University, 2022, 44(8): 797-804. DOI： 10.16016/j.2097-0927.202202052.

摘要

目的

探讨乙型肝炎病毒(hepatitis B virus，HBV)感染孕妇分娩婴幼儿HBV血清标志物(HBV markers

HBV-M)的动态变化规律及其临床意义。

方法

纳入2016年1月至2020年4月于我院登记并孕检的HBV感染孕妇分娩的婴幼儿302例。检测HBV感染孕妇妊娠晚期HBV-M、HBV DNA及其分娩婴幼儿6~12月龄(时相点1，T1)和20~30月龄(时相点2，T2)血清HBV-M，分析其动态变化规律及影响因素。

结果

在2个时相点婴幼儿HBsAg均为阴性，T1时相点血清抗-HBs阳性301例、HBeAg阳性3例、抗-HBe阳性46例、抗-HBc阳性207例，均随婴幼儿年龄增长逐渐下降；至T2时相点有8例抗-HBs转阴，而HBeAg、抗-HBe、抗-HBc均转阴；T1时相点抗-HBs的滴度越低越容易转阴。在T2时相点幼儿抗-HBs不同滴度与喂养方式、分娩方式以及母亲HBV DNA等因素无关。

结论

经母婴阻断的婴幼儿血清HBeAg、抗-HBe及抗-HBc均来自母体，且逐步被代谢；HBV母婴阻断成功率高，初次检测抗-HBs滴度相对较低者，应缩短复查时间。

Abstract

Objective

To investigate the dynamic changes of HBV serum markers (HBV-M) in pregnant women with HBV infection and its clinical significance.

Methods

A total of 302 infants delivered by HBV infected pregnant women registered and examined in our hospital from January 2016 to April 2020 were included. Serum HBV-M and HBV-DNA were detected in the 302 pregnant women during late pregnancy and in their infants aged 6~12 months (time point 1

T1) and 20~30 months (time point 2

T2). The dynamic changes and influencing factors were analyzed.

Results

For the infants

HBsAg was negative at both time points

and there were 301 cases of anti-HBs positive

3 cases of HBeAg positive

46 cases of anti-HBe positive and 207 cases of anti-HBc positive at T1

and all these indicators were decreased gradually with the age of infants. At T2

8 cases of anti-HBs positive turned negative

while those of HBeAg

anti-HBe and anti-HBc positive turned negative. The lower the titer of T1 anti-HBs was

the more likely it was to turn negative. At T2

the titer of anti-HBs was not related to feeding mode

delivery mode and mother HBV DNA level.

Conclusion

Serum HBeAg

anti-HBe and anti-HBc are all derived from the mother and metabolized gradually. The success rate of mother-to-child prevention for HBV infected pregnant women is quite high. If the titer of the initial test is relatively low

the time of reexamination should be shortened.

关键词

Keywords

references

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