Current status and perspective of 3D printing technology to construct articular osteochondral scaffolds with boundary structure

Liu YANG; Yang HUANG

doi:10.16016/j.2097-0927.202112206

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Current status and perspective of 3D printing technology to construct articular osteochondral scaffolds with boundary structure

Monographic Reports: Clinical application of 3D printing technology in bone and joint surgery | 更新时间：2026-01-09

- Current status and perspective of 3D printing technology to construct articular osteochondral scaffolds with boundary structure
- Journal of Army Medical University Vol. 44, Issue 15, Pages: 1493-1500(2022)
- 作者机构：
  
  400038 重庆，陆军军医大学(第三军医大学)第一附属医院关节外科
- 作者简介：
- 基金信息：
  
  the Special Project of Chongqing Postdoctoral Research(2021XM3092)
- DOI：10.16016/j.2097-0927.202112206
  CLC： R319;R684
- Received：23 December 2021，
  
  Revised：2022-05-19，
  
  Published：15 August 2022
- 稿件说明：
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Liu YANG, Yang HUANG. Current status and perspective of 3D printing technology to construct articular osteochondral scaffolds with boundary structure[J]. Journal of Army Medical University, 2022, 44(15): 1493-1500.
DOI：

Liu YANG, Yang HUANG. Current status and perspective of 3D printing technology to construct articular osteochondral scaffolds with boundary structure[J]. Journal of Army Medical University, 2022, 44(15): 1493-1500. DOI： 10.16016/j.2097-0927.202112206.

摘要

关节骨软骨缺损在临床上十分常见，组织工程技术方法可为这一病损提供具有广阔前景的再生治疗方案。关节骨软骨单元由透明软骨、钙化软骨层、软骨下骨构成，其中钙化软骨层作为关节骨与软骨的界层结构，在应力传导和微环境调控方面均具有重要作用；含有界层结构复合支架用于再生修复这类缺损是未来关节骨软骨复合组织工程的发展方向。3D打印制造技术具有快速、精准、个性化定制的优势和特点，能够满足含界层结构的关节骨软骨支架不规则几何外形与多层结构、成分差异化构建的需求。本文概述了关节骨软骨单元的形态结构、生化组分及生理功能，评述了关节骨软骨复合组织工程支架中构建其界层结构的必要性，以及利用材料挤出、熔融电写、静电纺丝、光固化和数字光处理等3D打印技术构建含界层结构骨软骨支架的方案。未来需要深入骨软骨界层结构的基础研究，并且积极开发和拓展3D打印技术在含有界层结构的关节骨软骨支架构建方面的应用，从而更好地实现骨软骨支架的功能和结构的仿生，最终提升各类伤病所致关节骨软骨缺损的再生治疗水平。

Abstract

Articular osteochondral defects are very common in clinical practice. Tissue engineering technology provides a promising treatment strategy for the disease. The articular osteochondral unit is composed of hyaline cartilage

calcified cartilage zone and subchondral bone. As the boundary structure between articular bone and cartilage

calcified cartilage zone plays an important role in stress conduction and microenvironment regulation. Composite scaffolds with boundary structure for defect repair is a development direction of osteochondral tissue engineering in the future. 3D printing technology has the advantages and characteristics of speediness

accuracy and personalized customization

which meet the needs of geometric shape

multi-layer structure and component differentiation when manufacturing osteochondral scaffold with boundary structure. We summarize the morphological structure

biochemical components and physiological functions of articular osteochondral unit

and comment on the necessity of constructing its boundary structure in articular osteochondral composite tissue engineering scaffold and its construction scheme by 3D printing technologies

such as material extrusion

melt electro-writing

electro-spinning

stereolithography

and digital light processing. Deepening the basic research of articular cartilage boundary structure and expanding the application of 3D printing technology in the construction of osteochondral scaffolds containing boundary structure will realize the bionic function and structure of osteochondral scaffold

and finally improve the regeneration treatment of articular osteochondral defects caused by various injuries.

关键词

Keywords

references

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