Preparation and preliminary clinical application of 3D printed porous tantalum prosthesis for reconstruction of acetabular bone defect

Huaquan FAN; Fuyou WANG; Rui HE; Xin CHEN; Liu YANG

doi:10.16016/j.2097-0927.202112205

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Preparation and preliminary clinical application of 3D printed porous tantalum prosthesis for reconstruction of acetabular bone defect

Monographic Reports: Clinical application of 3D printing technology in bone and joint surgery | 更新时间：2026-01-09

- Preparation and preliminary clinical application of 3D printed porous tantalum prosthesis for reconstruction of acetabular bone defect
- Journal of Army Medical University Vol. 44, Issue 15, Pages: 1516-1522(2022)
- 作者机构：
  
  400038 重庆，陆军军医大学(第三军医大学)第一附属医院关节外科
- 作者简介：
- 基金信息：
  
  the Key R&D Program of Guangdong Province(2018B090906003);the National Key R&D Program of China(2016YFB1101404);the Individualized Training Project of Excellent Talent Pool of Army Medical University(XZ-2019-505-038)
- DOI：10.16016/j.2097-0927.202112205
  CLC： R318.08;R319;R687.4
- Received：23 December 2021，
  
  Revised：2022-05-26，
  
  Published：15 August 2022
- 稿件说明：
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Huaquan FAN, Fuyou WANG, Rui HE, et al. Preparation and preliminary clinical application of 3D printed porous tantalum prosthesis for reconstruction of acetabular bone defect[J]. Journal of Army Medical University, 2022, 44(15): 1516-1522.
DOI：

Huaquan FAN, Fuyou WANG, Rui HE, et al. Preparation and preliminary clinical application of 3D printed porous tantalum prosthesis for reconstruction of acetabular bone defect[J]. Journal of Army Medical University, 2022, 44(15): 1516-1522. DOI： 10.16016/j.2097-0927.202112205.

摘要

目的

建立3D打印多孔钽金属假体重建髋臼骨缺损的制备技术方法，并评价其临床初步应用效果。

方法

采用纳排标准筛选2018年6-12月在本院关节外科拟行全髋关节置换术合并髋臼Paprosky ⅡB型骨缺损的患者4例，临床试用髋臼骨缺损假体依据患者全骨盆CT影像数据，使用专用软件3D个性化设计及粉床电子束增材制造装备制备成形。比较患者术前术后视觉模拟量表(visual analog scale

VAS)、SF-36生活质量评分，髋关节Harris评分，观察其术后并发症发生情况，完成末次随访X线检查。

结果

4例行计算机设计、个性化3D打印多孔钽金属假体辅助全髋关节置换修复Paprosky ⅡB型骨缺损的患者术后取得良好的疗效，随访时间(22.5±3.5)个月，未出现手术相关并发症。末次随访时，Harris评分(86.2±0.3)明显高于术前评分(64.5±12.1)，表明患者髋关节功能明显改善，VAS评分(2.5±0.7)低于术前(7.5±0.7)，SF-36评分(81.6±3.8)高于术前(39.3±6.3)，生活质量均较术前显著改善。放射学检查显示植入关节的髋关节假体和3D打印多孔钽金属骨缺损假体稳定性良好，未见X线透亮线，髋臼骨缺损得到有效重建。

结论

成功建立个性化3D打印多孔钽金属假体重建髋臼骨缺损的制备技术方法，其临床初步应用效果优良。

Abstract

Objective

To establish the preparation technology and production method of 3D printed porous tantalum prosthesis for reconstruction of acetabular bone defect and to evaluate its efficacy in preliminary clinical application.

Methods

Four patients with Paprosky ⅡB bone defect of the acetabulum who were going to undergo total hip arthroplasty (THA) in our center from June to December 2018 were recruited in this study according to our inclusion and exclusion criteria. Based on the personalized CT data of the patient's complete pelvis

the prosthesis for acetabular bone defect was designed by specialized 3D software and fabricated by powder bed electron beam additive manufacturing. The hip visual analog scale (VAS) score

36-item short-form (SF-36) score and Harris score for hip joint before and after operation were compared

the postoperative complications were observed

and radiographical examination was completed at the last follow-up.

Results

All patients obtained good postoperative outcomes after undergoing computer-designed

personalized 3D printed porous tantalum prosthesis assisted THA to repair Paprosky ⅡB acetabular defects. During a follow-up period of 22.5±3.5 months

no surgery-related complications occurred. At the last follow-up

the Harris score was 86.2±0.3

which was significantly higher than that before operation (64.5±12.1)

indicating significantly improved hip function; The VAS score was 2.5±0.7

obviously lower than that before operation (7.5±0.7); the SF-36 score was increased from 39.3±6.3 to 81.6±3.8. Compared to preoperative conditions

significant improvement was achieved in quality of life. Radiological examination showed that the implanted hip prosthesis and the 3D printed porous tantalum prosthesis for the bone defect had good stability

no radiolucent line was observed

and the acetabular bone defect was effectively reconstructed.

Conclusion

Our established preparation technology of personalized 3D printed porous tantalum prosthesis has demonstrated excellent effectiveness for reconstruction of acetabular bone defects in preliminary clinical application.

关键词

Keywords

references

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