Differences of gutmicrobiota and serum biochemical markers between Tibetan and Han population with different body mass indexes

Ruocheng LUO; Zehui HONG; Baochao ZHANG; Ke DONG; Lan YOU; Jingxian CHEN; Haojiang ZUO; Xing ZHAO; Xiaofang PEI

doi:10.16016/j.2097-0927.202112076

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Differences of gutmicrobiota and serum biochemical markers between Tibetan and Han population with different body mass indexes

Public Health and Preventive Medicine | 更新时间：2026-01-09

- Differences of gutmicrobiota and serum biochemical markers between Tibetan and Han population with different body mass indexes
- Journal of Army Medical University Vol. 44, Issue 14, Pages: 1486-封三(2022)
- 作者机构：
  
  610041 成都，四川大学华西公共卫生学院/华西第四医院
- 作者简介：
- 基金信息：
  
  the National Key Research and Development Program(2017YFC0907305);the Project of Application Basic Research of Sichuan Provincial Department of Science and Technology(2020YJ0233);the Project of Technology Innovation Development Program of Science and Technology Department of Chengdu(2019-YF05-01247-SN)
- DOI：10.16016/j.2097-0927.202112076
  CLC： R195.1;R372;R446.112
- Received：09 December 2021，
  
  Revised：2022-02-11，
  
  Published：30 July 2022
- 稿件说明：
移动端阅览
Ruocheng LUO, Zehui HONG, Baochao ZHANG, et al. Differences of gutmicrobiota and serum biochemical markers between Tibetan and Han population with different body mass indexes[J]. Journal of Army Medical University, 2022, 44(14): 1486-封三.
DOI：

Ruocheng LUO, Zehui HONG, Baochao ZHANG, et al. Differences of gutmicrobiota and serum biochemical markers between Tibetan and Han population with different body mass indexes[J]. Journal of Army Medical University, 2022, 44(14): 1486-封三. DOI： 10.16016/j.2097-0927.202112076.

摘要

目的

对比研究四川红原藏族与成都汉族不同体质指数(BMI)人群的肠道菌群及生化指标差异。

方法

于2018年5月至2019年9月在成都青白江、阿坝红原地区收集藏、汉族居民的人口学信息、粪便与血液样本。根据BMI与民族，将研究对象分为藏族肥胖、藏族非肥胖、汉族肥胖与汉族非肥胖等4组，测定肠道菌群及血液生化指标并分析各组差异。

结果

藏族人群甘油三酯(triacylglycerol，TG)水平低于汉族人群，藏、汉族肥胖组总肝固醇(levels of total liver cholesterol，CHOL)、TG、低密度脂蛋白胆固醇(low-density lipoprotein cholesterol，LDL-C)、谷氨酰转移酶(gamma-glutamyl transferase，GGT)、丙氨酸转氨酶(alanine aminotransferase，ALT)、碱性磷酸酶(alkaline phosphatase，ALP)水平均高于非肥胖人群，高密度脂蛋白胆固醇(high-density lipoprotein cholesterol，HDL-C)水平均低于非肥胖人群。藏族人群肠道菌群的物种丰富度与多样性高于汉族人群。汉族肥胖人群梭杆菌门的丰度高于汉族非肥胖人群(

0.05)，而厚壁菌门的丰度低于汉族非肥胖人群(

0.05)；藏族肥胖人群疣微菌门的丰度低于藏族非肥胖人群(

0.05)。属水平上，藏族人群共有12个菌属的丰度高于汉族人群(

0.05)，而汉族人群共有6个菌属的丰度高于藏族人群(

0.05)。其中，在藏族人群中丰度较高的柯林斯氏菌属与TG、LDL-C、GGT、ALT、AST呈正相关，与HDL-C呈负相关(|

|＞0，

0.05)；汉族人群中丰度较高的梭杆菌属与TG、GGT呈正相关，与HDL-C呈负相关(|

|＞0，

0.05)。

结论

藏汉不同BMI人群的肠道菌群结构和生化指标差异明显，柯林斯氏菌属、梭杆菌属可能分别与藏族和汉族人群的肥胖有关。

Abstract

Objective

To compare and analyze the differences in the gut microbiota and serum biochemical markers between the Tibetan people in Hongyuan

and Han people in Chengdu

Sichuan Province with different body mass indexes (BMI).

Methods

From May 2018 to September 2019

Tibetan and Han residents from Aba Hongyuan area and Chengdu Qingbaijiang area were recruited based on the China multi-ethnic cohort (CMEC). Their demographic information

height

body mass

stool and blood samples were collected. According to BMI and ethnic groups

the subjects were subsequently divided into obese and non-obese Tibetans

as well as corresponding Han groups. The intestinal microflora and blood biochemical markers were measured

and the differences among groups were compared and analyzed.

Results

The triacylglycerol (TG) level in Tibetan population was inferior to that in Han generally. The levels of total liver cholesterol (CHOL)

low-density lipoprotein cholesterol (LDL-C)

gamma-glutamyl transferase (GGT)

alanine aminotransferase (ALT)

and alkaline phosphatase (ALP) were higher

while the level of high-density lipoprotein cholesterol (HDL-C) was lower in the obese population than the non-obese population. The species richness and diversity of gut microbiota were greater in Tibetans than in Han population. The abundance of

fusobacterium

in the obese Han group was more than that in the non-obese Han (

0.05)

whereas that of

firmicutes

showed the opposite (

0.05). The abundance of

verrucomicrobia

in the obese Tibetans was lower than that in the non-obese Tibetans (

0.05). At the genus level

the Tibetan group had 12 genera of higher abundance than Han population (

0.05)

while the abundance of 6 genera in the Han group was greater than that in Tibetan population (

0.05). Among them

collinsella

genus with superior abundance in the Tibetan population was positively correlated with TG

LDL-C

GGT

ALT

and aspartate aminotransferase (AST)

and negatively correlated with HDL-C (|

0.05). The

fusobacterium

genus

which was more abundant in Han population

was posit

ively correlated with TG and GGT

and negatively correlated with HDL-C (|

0.05).

Conclusion

The gut microbiota structure and biochemical indexes vary considerably among Tibetan and Han population with different BMI.

collinsella

and

fusobacterium

may be related to the obesity of Tibetans and Han population

respectively.

关键词

Keywords

references

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