Macular retinal vascular density and thickness in high myopia patients

Shuyue ZHENG; Li SHUI; Chong TANG; Qi LI

doi:10.16016/j.2097-0927.202111051

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Macular retinal vascular density and thickness in high myopia patients

Clinical Medicine | 更新时间：2026-01-09

- Macular retinal vascular density and thickness in high myopia patients
- Journal of Army Medical University Vol. 44, Issue 10, Pages: 1067-1073(2022)
- 作者机构：
  
  400016 重庆，重庆医科大学附属第一医院眼科
- 作者简介：
- 基金信息：
- DOI：10.16016/j.2097-0927.202111051
  CLC： R195.4;R339.146;R778.11
- Received：07 November 2021，
  
  Revised：2022-01-27，
  
  Published：30 May 2022
- 稿件说明：
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Shuyue ZHENG, Li SHUI, Chong TANG, et al. Macular retinal vascular density and thickness in high myopia patients[J]. Journal of Army Medical University, 2022, 44(10): 1067-1073.
DOI：

Shuyue ZHENG, Li SHUI, Chong TANG, et al. Macular retinal vascular density and thickness in high myopia patients[J]. Journal of Army Medical University, 2022, 44(10): 1067-1073. DOI： 10.16016/j.2097-0927.202111051.

摘要

目的

应用光学相干断层扫描血管成像技术(optical coherence tomography angiography

OCTA)检测高度近视人群的黄斑区视网膜血管密度(vascular density

VD)及厚度(retinal thickness，RT)，并分析其相关性。

方法

纳入2020年9月至2021年9月于本院眼科门诊就诊的18~40岁近视患者共110例(110眼)，根据等效球镜度(spherical equivalent refraction

SER)将其分为高度近视组(SER＜-6.00 D)57眼、对照组(-6.00~-0.50 D)53眼。对所有受检者进行OCTA检查，量化黄斑区各部位视网膜厚度及表层微血管密度，比较对照组及高度近视组各部位视网膜微血管密度及视网膜厚度的差异，并进行相关性分析。

结果

高度近视组黄斑区内环范围内血管长度密度(vascular length density

VLD)、血管灌注密度(vascular perfusion density，VPD)较对照组有所下降(

＜0.05)，外环VLD、VPD无明显变化；黄斑中心凹无血管区(foveal avascular zone

FAZ)的相关指标包括面积、周长、充实度两组间差异均无统计学意义；与对照组相比，高度近视组黄斑区中心凹及外环上方RT有所减少(

＜0.05)，内环RT两组间无明显差异。相关性分析表明，黄斑各分区VLD和VPD均呈正相关(

＜0.05)；黄斑中心凹及外环各象限的VLD、VPD与对应区域RT呈正相关(

＜0.05)，内环各象限VLD、VPD与RT无明显相关性；内环部分象限及外环整体RT与SER呈正相关(

＜0.05)，与眼轴(axial length

AL)呈负相关(

＜0.05)；黄斑区VLD、VPD与SER呈正相关，与AL呈负相关(

＜0.05)。

结论

黄斑各区视网膜厚度及血管密度随近视程度增加而减少，早期应用OCTA检测近视人群视网膜结构和血流循环的变化，有利于评估和监测近视进展。

Abstract

Objective

To measure the macular vascular density (VD) and retinal thickness (RT) of highly myopic patients by optical coherence tomography angiography (OCTA) and analyze their correlation.

Methods

A total of 110 myopia patients (110 eyes) aged 18~40 years who attended the Ophthalmology Clinic of the First Affiliated Hospital of Chongqing Medical University from September 2020 to September 2021 were included. According to spherical equivalent refraction (SER)

they were divided into high myopia (HM) group (SER < -6.00 D

57 eyes) and control group (-6.00~-0.50 D

53 eyes). OCTA was performed on all subjects to quantify the retinal thickness and superficial vessel density. The differences in VD and RT were compared between the control group and HM group

and correlation analysis was carried out.

Results

In general

the vascular length density (VLD) and vascular perfusion density (VPD) in the inner ring were significantly lower in the HM group than the control group (

0.05). The perifoveal VLD and VPD had no significant changes. There was no statistically significant difference in the characteristics of foveal avascular zone (FAZ) including area

perimeter and circularity between the 2 groups (

0.05). The RT of the macular fovea and perifoveal's superior side of the macular area was decreased in the HM group than the control group (

0.05)

and there were no significant differences in the thickness of the parafoveal quadrants between the 2 groups. Correlation analysis showed that the VLD and VPD of each subzone of the macula were positively correlated (

0.05). The VLD and VPD of the fovea and the perifoveal quadrants were positively correlated with the RT of the corresponding area (

0.05)

while the VLD and VPD of the inner ring had no significant correlation with the RT. RT of partial quadrants of the inner ring and the overall outer ring were positively correlated with SER (

0.05)

and negatively correlated with axial length (AL) (

0.05). VLD and VPD were roughly positively correlated with SER and negatively correlated with AL (

0.05).

Conclusion

RT and VD in macular area are decreased with increased myopia. Early application of OCTA to detect the changes of retinal structure and blood flow circulation in myopic population is helpful for evaluating and monitoring the progress of myopia.

关键词

Keywords

references

HOLDEN B A, FRICKE T R, WILSON D A, et al . Global prevalence of myopia and high myopia and temporal trends from 2000 through 2050[J ] . Ophthalmology, 2016, 123(5): 1036-1042. DOI: 10.1016/j.ophtha.2016.01.006.

OHNO-MATSUI K, LAI T Y Y, LAI C C, et al . Updates of pathologic myopia[J ] . Prog Retin Eye Res, 2016, 52: 156-187. DOI: 10.1016/j.preteyeres.2015.12.001.

NG D S C, CHEUNG C Y L, LUK F O, et al . Advances of optical coherence tomography in myopia and pathologic myopia[J ] . Eye (Lond), 2016, 30(7): 901-916. DOI: 10.1038/eye.2016.47.

MRUGACZ M, BRYL A. Evaluation of the arterial blood flow parameters in the eye of myopic patients[J]. Pol Merkur Lekarski, 2013, 34(202): 205-209.

WANG X L, KONG X M, JIANG C H, et al . Is the peripapillary retinal perfusion related to myopia in healthy eyes? A prospective comparative study[J ] . BMJ Open, 2016, 6(3): e010791. DOI: 10.1136/bmjopen-2015-010791.

YAPRAK A C, YAPRAK L. Retinal microvasculature and optic disc alterations in non-pathological high myopia with optical coherence tomography angiography[J]. Graefes Arch Clin Exp Ophthalmol, 2021, 259(11): 3221-3227. DOI: 10.1007/s00417-021-05216-x.

VERHOEVEN V J, WONG K T, BUITENDIJK G H, et al . Visual consequences of refractive errors in the general population[J ] . Ophthalmology, 2015, 122(1): 101-109. DOI: 10.1016/j.ophtha.2014.07.030.

KUMAR A, CHAWLA R, KUMAWAT D, et al . Insight into high myopia and the macula[J ] . Indian J Ophthalmol, 2017, 65(2): 85-91. DOI: 10.4103/ijo.IJO_863_16.

WANG T T, LI H, ZHANG R R, et al . Evaluatio n of retinal vascular density and related factors in youth myopia without maculopathy using OCTA[J ] . Sci Rep, 2021, 11(1): 15361. DOI: 10.1038/s41598-021-94909-8.

LI M, YANG Y, JIANG H, et al . Retinal microvascular network and microcirculation assessments in high myopia[J ] . Am J Ophthalmol, 2017, 174: 56-67. DOI: 10.1016/j.ajo.2016.10.018.

MO J, DUAN A L, CHAN S, et al . Vascular flow density in pathological myopia: an optical coherence tomography angiography study[J ] . BMJ Open, 2017, 7(2): e013571. DOI: 10.1136/bmjopen-2016-013571.

YANG S Q, ZHOU M W, LU B, et al . Quantification of macular vascular density using optical coherence tomography angiography and its relationship with retinal thickness in myopic eyes of young adults[J ] . J Ophthalmol, 2017, 2017: 1397179. DOI: 10.1155/2017/1397179.

田春柳, 赵军, 张娟美, 等. 基于OCTA的高度近视患眼黄斑区视网膜血管密度分析[J]. 眼科新进展, 2020, 40(3): 257-260. DOI: 10.13389/j.cnki.rao.2020.0060.

TIAN C L, ZHAO J, ZHANG J M, et al . Analysis of retinal vascular density in macular area of eyes with high myopia by OCTA[J ] . Recent Adv Ophthalmol, 2020, 40(3): 257-260. DOI: 10.13389/j.cnki.rao.2020.0060.

刘玉婷, 雷颖庆, 田敏, 等. 不同屈光度近视青少年儿童黄斑区血管密度和视网膜厚度的比较[J]. 国际眼科杂志, 2021, 21(5): 789-795. DOI: 10.3980/j.issn.1672-5123.2021.5.08.

LIU Y T, LEI Y Q, TIAN M, et al . Comparison of macular vascular density and retinal thickness in children with different degrees of myopia[J ] . Int Eye Sci, 2021, 21(5): 789-795. DOI: 10.3980/j.issn.1672-5123.2021.5.08.

YU J, JIANG C H, WANG X L, et al . Macular perfusion in healthy Chinese: an optical coherence tomography angiogram study[J ] . Invest Ophthalmol Vis Sci, 2015, 56(5): 3212-3217. DOI: 10.1167/iovs.14-16270.

IAFE N A, PHASUKKIJWATANA N, CHEN X J, et al . Retinal capillary density and foveal avascular zone area are age-dependent: quantitative analysis using optical coherence tomography angiography[J ] . Invest Ophthalmol Vis Sci, 2016, 57(13): 5780-5787. DOI: 10.1167/iovs.16-20045.

谭亮章, 田芳, 张红. 基于OCTA的近视性屈光参差患者黄斑区血流密度及视网膜厚度分析[J]. 眼科新进展, 2020, 40(3): 268-271. DOI: 10.13389/j.cnki.rao.2020.0063.

TAN L Z, TIAN F, ZHANG H. Analysis of blood flow density and retinal thickness in macular areas of patients with non-amblyopic myopic anisometropia by OCT[J]. Recent Adv Ophthalmol, 2020, 40(3): 268-271. DOI: 10.13389/j.cnki.rao.2020.0063.

JIANG H, DELGADO S, LIU C, et al . In vivo characterization of retinal microvascular network in multiple sclerosis[J ] . Ophthalmology, 2016, 123(2): 437-438. DOI: 10.1016/j.ophtha.2015.07.026..

黄灿凤. OCTA在不同程度近视眼黄斑和视乳头的应用研究[D]. 福州: 福建医科大学, 2019. DOI: 10.27020/d.cnki.gfjyu.2019.000792.

HUANG C F. Application of OCTA in the macula and optic disc of different degrees of myopia[D]. Fuzhou: Fujian Medical University, 2019. DOI: 10.27020/d.cnki.gfjyu.2019.000792.

YANG D W, CAO D, ZHANG L, et al . Macular and peripapillary vessel density in myopic eyes of young Chinese adults[J ] . Clin Exp Optom, 2020, 103(6): 830-837. DOI: 10.1111/cxo.13047.

廖燕红, 龚雁, 陈利双, 等. 不同轴长高度近视黄斑区微血管的光学相干断层扫描血管成像观察[J]. 现代实用医学, 2020, 32(11): 1377-1379. DOI: 10.3969/j.issn.1671-0800.2020.11.036.

LIAO Y H, GONG Y, CHEN L S, et al . Observation of macular microvessels in high myopia with different axial lengths by optical coherence tomography angiography[J ] . Mod Pract Med, 2020, 32(11): 1377-1379. DOI: 10.3969/j.issn.1671-0800.2020.11.036.

GUO Y X, PANG Y L, KANG Y J, et al . Correlations among peripapillary vasculature, macular superficial capillaries, and eye structure in healthy and myopic eyes of Chinese young adults (STROBE)[J ] . Medicine (Baltimore), 2020, 99(37): e22171. DOI: 10.1097/MD.0000000000022171.

HWANG Y H, KIM Y Y. Macular thickness and volume of myopic eyes measured using spectral-domain optical coherence tomography[J]. Clin Exp Optom, 2012, 95(5): 492-498. DOI: 10.1111/j.1444-0938.2012.00749.x.

WU P C, CHEN Y J, CHEN C H, et al . Assessment of macular retinal thickness and volume in normal eyes and highly myopic eyes with third-generation optical coherence tomography[J ] . Eye, 2008, 22(4): 551-555. DOI: 10.1038/sj.eye.6702789.

ZHAO Z N, ZHOU X T, JIANG C H, et al . Effects of myopia on different areas and layers of the macula: a Fourier-domain optical coherence tomography study of a Chinese cohort[J ] . BMC Ophthalmol, 2015, 15: 90. DOI: 10.1186/s12886-015-0080-5.

刘克政, 许晓璇, 吴晓蓉, 等. 不同屈光度对近视黄斑区视网膜血管密度及厚度的影响研究[J]. 江西医药, 2020, 55(12): 1858-1861. DOI: 10.3969/j.issn.1006-2238.2020.12.038.

LIU K Z, XU X X, WU X R, et al . Effects of different d iopter on retinal vessel density and thickness in myopic macular area[J ] . Foreign Lang Teach Res, 2020, 55(12): 1858-1861. DOI: 10.3969/j.issn.1006-2238.2020.12.038.

冯立淼, 杨叶, 胡亮, 等. 应用光学相干断层扫描血管成像技术分析近视眼黄斑区微血管变化[J]. 温州医科大学学报, 2017, 47(6): 391-396. DOI: 10.3969/j.issn.2095-9400.2017.06.001.

FENG L M, YANG Y, HU L, et al . The analysis of macular microvasculature alteration of myopic eyes with optical coherence tomography angiography[J ] . J Wenzhou Med Univ, 2017, 47(6): 391-396. DOI: 10.3969/j.issn.2095-9400.2017.06.001.

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