Comparative analysis on quality and safety of autologous platelet-rich plasma collected and prepared by 2 methods

Nali SONG; Shichun WANG; Zhongmei YI; Bin ZHANG; Qi LIU; Sumei LI; Yahan FAN; Chunyan YAO

doi:10.16016/j.2097-0927.202110184

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Comparative analysis on quality and safety of autologous platelet-rich plasma collected and prepared by 2 methods

Clinical Medicine | 更新时间：2026-01-09

- Comparative analysis on quality and safety of autologous platelet-rich plasma collected and prepared by 2 methods
- Journal of Army Medical University Vol. 44, Issue 6, Pages: 571-575(2022)
- 作者机构：
  
  1.400038 重庆，陆军军医大学(第三军医大学)第一附属医院: 输血科，中国人民解放军重庆血站
  2.404300 重庆，重庆市忠县人民医院输血科
- 作者简介：
- 基金信息：
- DOI：10.16016/j.2097-0927.202110184
  CLC： R457.14
- Received：28 October 2021，
  
  Revised：2021-12-03，
  
  Published：30 March 2022
- 稿件说明：
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Nali SONG, Shichun WANG, Zhongmei YI, et al. Comparative analysis on quality and safety of autologous platelet-rich plasma collected and prepared by 2 methods[J]. Journal of Army Medical University, 2022, 44(6): 571-575.
DOI：

Nali SONG, Shichun WANG, Zhongmei YI, et al. Comparative analysis on quality and safety of autologous platelet-rich plasma collected and prepared by 2 methods[J]. Journal of Army Medical University, 2022, 44(6): 571-575. DOI： 10.16016/j.2097-0927.202110184.

摘要

目的

比较血袋法与单采法制备富血小板血浆(platelet-rich plasma

PRP)的质量及安全性。

方法

回顾性分析2019年7月至2021年8月在陆军军医大学第一附属医院输血科自体PRP采集的患者66例，根据制备方式分为血袋组和单采组，其中血袋组30例制备47次，单采组36例制备36次。比较2组PRP产品中红细胞、白细胞、血小板及产品倍数。收集患者有无不良反应的记录，并进行安全性评价。

结果

单采组制备时间、产品容量、产品浓度及产品倍数均优于血袋组，差异有统计学意义(

0.01)；红细胞混入量2组比较差异有统计学意义(

0.01)，血袋制备组少于单采制备组；白细胞混入量2组差异无统计学意义。两组患者均无不良反应。

结论

单采组PRP产品血小板浓度高于血袋组且用时更短，推荐单采制备为首选，血袋制备为备选。

Abstract

Objective

To compare the quality and safety of platelet-rich plasma (PRP) by blood bag and monopheresis.

Methods

A retrospective analysis was performed on 66 patients treated with autologous PRP therapy in the blood transfusion department of First Affiliated Hospital of Army Medical University from July 2019 to August 2021. According to preparation procedure

they were divided into blood bag group (

=30

with 47 times of preparation) and monopheresis group (

=36

with 36 times of preparation). The counts of erythrocytes

leukocytes and platelets and product multiples in the PRP products were detected and compared between the 2 groups. Adverse reactions were recorded and safety was evaluated.

Results

The preparation time

product volume

product concentration and product multiple were significantly better in the monopheresis group than the blood bag group (

0.01). The amount of mixed red blood cells was statistically less in the blood bag

group than the apheresis group (

0.01). There was no notable difference in the amount of mixed white blood cells between the 2 groups. No adverse reactions were seen in both groups.

Conclusion

The monopheresis PRP products have higher platelets concentration than those by blood bag and need shorter time of procedure group. Therefore

monopheresis is recommended as first choice and blood bag as the alternative.

关键词

Keywords

references

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