Hearing loss and pathogenesis in Graves' disease

Xiaoxia HU; Haidong WANG; Jie LI; Xia LIU; Jing DANG; Jing ZHU; Lei DUAN; Jirui HE; Xiaowen LIU

doi:10.16016/j.2097-0927.202107169

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Hearing loss and pathogenesis in Graves' disease

Clinical Medicine | 更新时间：2026-01-09

- Hearing loss and pathogenesis in Graves' disease
- Journal of Army Medical University Vol. 44, Issue 5, Pages: 489-494(2022)
- 作者机构：
  
  1.730030 兰州，兰州大学第二医院：老年病科
  2.730050 兰州，甘肃省肿瘤医院麻醉科
  3.730030 兰州，兰州大学第二医院：耳鼻喉科
- 作者简介：
- 基金信息：
  
  the Natural Science Foundation of Gansu Province(20JR10RA750)
- DOI：10.16016/j.2097-0927.202107169
  CLC： R581.1;R764.04
- Received：27 July 2021，
  
  Revised：2021-08-24，
  
  Published：15 March 2022
- 稿件说明：
移动端阅览
Xiaoxia HU, Haidong WANG, Jie LI, et al. Hearing loss and pathogenesis in Graves' disease[J]. Journal of Army Medical University, 2022, 44(5): 489-494.
DOI：

Xiaoxia HU, Haidong WANG, Jie LI, et al. Hearing loss and pathogenesis in Graves' disease[J]. Journal of Army Medical University, 2022, 44(5): 489-494. DOI： 10.16016/j.2097-0927.202107169.

摘要

目的

研究Graves病患者的听力损失情况，探索可能的发病机制。

方法

纳入2019年9月至2021年3月在兰州大学第二医院门诊和住院部初诊的39例Graves病患者和22名健康对照受试者。HHIE-S量表初步评估受试者有无自觉听力损失，同时进行甲状腺激素和TRAB水平检测、纯音测听和声导抗检查，判断听力损失和激素水平及TRAB的相关性。

结果

HHIE-S量表显示39例Graves病患者自觉听力损失17例(43.6%)，纯音听阈阈值升高23例(59.0%)；所有受试者左右耳平均听阈无统计学差异；比较Graves病组和对照组在不同频率的阈值，除1 000 Hz外的其他频率Graves病组听阈显著高于健康对照组，差异有统计学意义(

0.05)；在4 000和8 000 Hz频率时Graves眼病组阈值明显高于Graves非眼病组(

0.01)；Graves病患者纯音听阈与甲状腺激素和TRAB无明显相关性。

结论

Graves病患者除1 000 Hz频率外，其余各检测频率均存在阈值升高而无明显自觉听力损失，合并Graves眼病时4 000和8 000 Hz高频听力损失更明显。

Abstract

Objective

To investigate the hearing loss of Graves patients and explore the possible pathogenesis.

Methods

A total of 39 Graves patients and 22 healthy control subjects who were initially admitted to the outpatient and inpatient departments of our hospital from September 2019 to March 2021 were enrolled in this study. Hearing Handicap Inventory Screening Version (HHIE-S) was used to assess whether the subjects had conscious hearing loss. Meanwhile

thyroid hormone and thyrotropin receptor antibody (TRAb) levels were detected

and pure tone audiometry and acoustic conductance were performed to judge the correlations of hearing loss with the hormone and TRAb levels.

Results

HHIE-S scale showed that 17 cases (43.6%) of 39 Graves patients had hearing loss

and 23 cases (59.0%) had increased pure tone threshold. There was no statistical difference in the average auditory threshold of all subjects. The hearing threshold was significantly higher in the Graves group than the healthy control group at frequencies other than 1 000 Hz (

0.05). At 4 000 Hz and 8 000 Hz

the thresholds of Graves eye disease group was significantly higher than that of Graves non-eye disease group (

0.01). No significant correlation was found of pure tone threshold with thyroid and TRAb levels in Graves patients.

Conclusion

Graves patients have no obvious conscious hearing loss at all detection frequencies except 1 000 Hz

and the high-frequency hearing loss at 4 000 Hz and 8 000Hz is more obvious in those with Graves eye disease.

关键词

Keywords

references

HUGET-PENNER S, FEIG D S. Maternal thyroid disease and its effects on the fetus and perinatal outcomes[J]. Prenat Diagn, 2020, 40(9): 1077-1084. DOI: 10.1002/pd.5684.

倪懿, 张西愿, 陈必良. 妊娠期甲状腺功能减退对子代脑发育的影响[J]. 中国妇幼健康研究, 2017, 28(2): 216-219. DOI: 10.3969/j.issn.1673-5293.2017.02.040.

NI Y, ZHANG X Y, CHEN B L. Hypothyroidism in pregnancy on offspring' s brain development[J]. Chin J Woman Child Heal Res, 2017, 28(2): 216-219. DOI: 10.3969/j.issn.1673-5293.2017.02.040.

包杰, 牛成玲, 杨永俊, 等. 甲状腺激素及TSH水平在妊娠甲亢和Graves病鉴别诊断中的意义[J]. 实验与检验医学, 2018, 36(5): 699-700, 765. DOI: 10.3969/j.issn.1674-1129.2018.05.020.

BAO J, NIU C L, YANG Y J, et al . Thyroid hormone and TSH levels in pregnancy hyperthyroidism and Graves' disease significance in differential diagnosis[J ] . Exp Lab Med, 2018, 36(5): 699-700, 765. DOI: 10.3969/j.issn.1674-1129.2018.05.020.

曾鹏, 余韵, 范淑贤, 等. 甲状腺相关眼病的EUGOGO临床分级特征[J]. 中山大学学报(医学版), 2018, 39(6): 884-890. DOI: 10.13471/j.cnki.j.sun.yat-sen.univ(med.sci).2018.0120.

ZENG P, YU Y, FAN S X, et al . Clinical manifestation of EUGOGO classification in Graves' orbitopathy[J ] . J Sun Yat Sen Univ Med Sci, 2018, 39(6): 884-890. DOI: 10.13471/j.cnki.j.sun.yat-sen.univ(med.sci).2018.0120.

翟秀云, 刘博, 张玉和, 等. 老年听力障碍筛查量表在老年性聋调查中的应用与相关性分析[J]. 中国耳鼻咽喉头颈外科, 2016, 23(1): 27-30. DOI: 10.16066/j.1672-7002.2016.01.009.

ZHAI X Y, LIU B, ZHANG Y H, et al . Application and relevance analysis of Hearing Handicap Inventory for the Elderly-Screening in presbycusis survey[J ] . Chin Arch Otolaryngol Head Neck Surg, 2016, 23(1): 27-30. DOI: 10.16066/j.1 672-7002.2016.01.009.

KAHALY G J, DOUGLAS R S, HOLT R J, et al . Teprotumumab for patients with active thyroid eye disease: a pooled data analysis, subgroup analyses, and off treatment follow-up results from two randomised, double-masked, placebo-controlled, multicentre trials[J ] . Lancet Diabetes Endocrinol, 2021, 9(6): 360-372.

丁利, 王扬天. 丙硫氧嘧啶治疗Graves病致耳聋1例报告[J]. 中国临床医学, 2020, 27(6): 1074-1077. DOI: 10.12025/j.issn.1008-6358.2020.20192233.

DING L, WANG Y T. Deafness caused by propylthiouracil in treatment of Graves' disease: a case report[J]. Chin J Clin Med, 2020, 27(6): 1074-1077. DOI: 10.12025/j.issn.1008-6358.2020.20192233.

BERKER D, KARABULUT H, ISIK S, et al . Evaluation of hearing loss in patients with Graves' disease[J ] . Endocrine, 2012, 41(1): 116-121. DOI: 10.1007/s12020-011-9515-9.

RUCKENSTEIN M J. Autoimmune inner ear disease[J]. Curr Opin Otolaryngol Head Neck Surg, 2004, 12(5): 426-430.

JIANG Z G, QIU J H, REN T Y, et al . Membrane properties and the excitatory junction potentials in smooth muscle cel ls of cochlear spiral modiolar artery in Guinea pigs[J ] . Hear Res, 1999, 138(1/2): 171-180. DOI: 10.1016/S0378-5955(99)00166-5.

KIMS Y, SONG Y S, WEE J H, et al . Association between SSNHL and thyroid diseases[J ] . Int J Environ Res Public Health, 2020, 17(22): E8419. DOI: 10.3390/ijerph17228419.

ARDUC A, ISIK S, ALLUSOGLU S, et al . Evaluation of hearing functions in patients with euthyroid Hashimoto's thyroiditis[J ] . Endocrine, 2015, 50(3): 708-714.

高荣, 王庆祝, 吴丽娜, 等. 血清TRAb IgG亚型在甲状腺相关性眼病患者中的特征及临床意义[J]. 中华内分泌代谢杂志, 2020, 36(4): 315-316.

GAO R, WANG Q Z, WU L N, et al . The characteristics and clinical significance of serum TRAb IgG subtypes in patients with thyroid-associated ophthalmo-pathy[J ] . Chin J Endocrinol Metab, 2020, 36(4): 315-316.

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