Predictive value of soluble urokinase-type plasminogen activator receptor in patients with severe acute pancreatitis

Yang LI; Yinjie ZHAO; Haiyan YU; Song HUANG; Minghua LIU; Qiang XIANG

doi:10.16016/j.2097-0927.202107019

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Predictive value of soluble urokinase-type plasminogen activator receptor in patients with severe acute pancreatitis

Clinical Medicine | 更新时间：2026-01-09

- Predictive value of soluble urokinase-type plasminogen activator receptor in patients with severe acute pancreatitis
- Journal of Army Medical University Vol. 44, Issue 3, Pages: 241-245(2022)
- 作者机构：
  
  400038 重庆，陆军军医大学(第三军医大学)第一附属医院急救部
- 作者简介：
- 基金信息：
  
  the General Project of Technology Innovation and Application Development Program of Chongqing(cstc2019jscx-msxmX0222);the Special Project of Science and Technology Innovation Ability Promotion of Army Medical University(2019XLC3001)
- DOI：10.16016/j.2097-0927.202107019
  CLC： R181.32;R446.112;R576
- Received：03 July 2021，
  
  Revised：2021-11-09，
  
  Published：15 February 2022
- 稿件说明：
移动端阅览
Yang LI, Yinjie ZHAO, Haiyan YU, et al. Predictive value of soluble urokinase-type plasminogen activator receptor in patients with severe acute pancreatitis[J]. Journal of Army Medical University, 2022, 44(3): 241-245.
DOI：

Yang LI, Yinjie ZHAO, Haiyan YU, et al. Predictive value of soluble urokinase-type plasminogen activator receptor in patients with severe acute pancreatitis[J]. Journal of Army Medical University, 2022, 44(3): 241-245. DOI： 10.16016/j.2097-0927.202107019.

摘要

目的

探讨可溶性尿激酶型纤溶酶原激活物受体(soluble urokinase-type plasminogen activator receptor，suPAR)对重症急性胰腺炎(acute severe pancreatitis，SAP)的预测价值。

方法

采用前瞻性队列研究设计，纳入2021年3月1日至6月1日我科收治的急性胰腺炎患者103例[其中SAP 23例，非重症急性胰腺炎(non severe acute pancreatitis

NSAP)80例

]

，采集患者入院即刻血浆样本。同时，招募同期健康体检者30例作为对照组。采用酶联免疫吸附试验检测所有受试者血浆suPAR水平。收集急性胰腺炎患者的一般临床资料及降钙素原(procalcitonin，PCT)、白介素-6(interleukin-6，IL-6)、C反应蛋白(C-reactive protein，CRP)、D-二聚体、血清钙(calcium，Ca

)水平以及血常规、血生化检查结果，并计算急性生理学与慢性健康状况评分系统Ⅱ(acute physiology and chronic health evaluation

APACHE Ⅱ)评分和Ranson’s评分。记录对照组受试者人口学特征(年龄和性别)。采用Pearson相关分析suPAR与APACHE II评分、Ranson’s评分的相关性；采用多因素Logistic回归分析SAP的独立预测因素；采用受试者工作特征(receiver op

erating characteristic，ROC)曲线下面积(area under the curve，AUC)评估上述各独立预测因素对SAP的预测价值。

结果

相较于对照组，NSAP及SAP患者血浆suPAR水平明显升高(

＜0.05)，SAP患者suPAR水平明显高于NSAP患者(

＜0.05)。急性胰腺炎患者血浆suPAR水平与APACHE Ⅱ评分、Ranson’s评分呈正相关(

=0.554、

=0.485，

＜0.05)，多因素Logistic回归分析表明suPAR、D-二聚体、Ca

是SAP的独立预测因素，ROC曲线分析显示血浆suPAR对SAP有较好的预测价值(AUC=0.869)。

结论

血浆suPAR水平与急性胰腺炎患者病情严重程度相关，对预测SAP具有重要价值。

Abstract

Objective

To explore the predictive value of soluble urokinase-type plasminogen activator receptor (suPAR) for severe acute pancreatitis (SAP).

Methods

A prospective cohort study was designed to enroll 103 patients with acute pancreatitis who were admitted to our department from March 1 to June 1

2021

including 23 SAP and 80 non-severe acute pancreatitis (NSAP). Another 30 healthy subjects were recruited concurrently as control group. The plasma samples of all subjects were collected on the first day of admission to detect the level of suPAR using ELISA. General clinical data and the levels of procalcitonin (PCT)

interleukin-6 (IL-6)

C-reactive protein (CRP)

D-dimer and serum calcium (Ca

)

as well as the results of blood routine and biochemical examinations of patients were all collected. Acute Physiology and Chronic Health Evaluation (APACHEⅡ) score and Ranson's score were subsequently calculated. For the control subjects

only their demographic characteristics (age and gender) were collected. Statistical analysis was adopted on the above data.

Results

The plasma suPAR level was significantly higher in the patients with NSAP and SAP than the control group (

0.05)

and also notably higher in those of the SAP group than those out of the NSAP patients (

0.05). Pearson correlation ana

lysis showed that plasma suPAR level was positively correlated with both APACHE Ⅱ score and Ranson's score (

=0.554

=0.485

0.05). Multivariate Logistic regression analysis indicated that suPAR

D-dimer and Ca

levels were independent predictors of SAP. ROC curve demonstrated that serum suPAR had a good predictive value for SAP (AUC=0.869).

Conclusion

The plasma level of suPAR is closely correlated with the severity of acute pancreatitis

and plays an important role in prediction of SAP.

关键词

Keywords

references

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