Association between visceral adiposity index and outcome of prediabetes: report of 1 064 cases

Ying MIAO; Pan CHEN; Pijun YAN; Qin WAN

doi:10.16016/j.1000-5404.2202006124

您当前的位置：

首页 >

文章列表页 >

Association between visceral adiposity index and outcome of prediabetes: report of 1 064 cases

Clinical Medicine | 更新时间：2026-01-09

- Association between visceral adiposity index and outcome of prediabetes: report of 1 064 cases
- Journal of Third Military Medical University Vol. 42, Issue 21, Pages: 2154-2161(2020)
- 作者机构：
  
  646000 四川泸州，西南医科大学附属医院内分泌科
- 作者简介：
- 基金信息：
  
  the Key Development and Research Plan of China(20160901200)
- DOI：10.16016/j.1000-5404.2202006124
  CLC： R181.23;R344.2;R587.1
- Received：13 June 2020，
  
  Revised：2020-07-15，
  
  Published：15 November 2020
- 稿件说明：
移动端阅览
Ying MIAO, Pan CHEN, Pijun YAN, et al. Association between visceral adiposity index and outcome of prediabetes: report of 1 064 cases[J]. Journal of Third Military Medical University, 2020, 42(21): 2154-2161.
DOI：

Ying MIAO, Pan CHEN, Pijun YAN, et al. Association between visceral adiposity index and outcome of prediabetes: report of 1 064 cases[J]. Journal of Third Military Medical University, 2020, 42(21): 2154-2161. DOI： 10.16016/j.1000-5404.2202006124.

摘要

目的

通过队列研究分析内脏脂肪指数(visceral adiposity index，VAI)与糖尿病前期对象5年转归糖尿病的相关性；并比较VAI、体质量指数(BMI)、腰围(waist circumference

WC)、腰臀比(waist to hip ratio，WHR)预测糖尿病前期对象随访5年转归糖尿病的能力。

方法

选取2011年4-11月参与泸州地区2型糖尿病危险因素的动态监测与社区综合防治的流行病学调查研究中基线调查确诊为糖尿病前期人群1 125人，将研究对象按VAI的四分位数(第1四分位数组:0.37~1.29，第2四分位数组:1.30~2.01，第3四分位数组:2.02~3.28，第4四分位数组:3.29~36.12)分为4组，进行为期5年的随访，并观察转归糖尿病的情况。通过单因素及多因素Logistic回归分析VAI对糖尿病前期对象转归糖尿病的影响，并计算ROC曲线下面积，比较VAI、BMI、腰围、腰臀比4个肥胖指标预测糖尿病前期对象转归糖尿病的能力。

结果

完成随访的1 064人中，转归为糖尿病者237人；4组对象转归糖尿病的比较结果显示第4四分位组(94人)＞第3四分位组(68人)＞第2四分位组(46人)＞第1四分位组(29人)，差异有统计学意义(χ

=51.566，

0.001)；Logistic回归分析结果显示:在未调整任何变量，以及调整年龄、性别、身高、收缩压、三酰甘油、高密度脂蛋白胆固醇、吸烟、饮茶的影响后，较高四分位数分组的糖尿病前期对象比较低四分位数分组的研究对象转归糖尿病的风险更高；ROC曲线下面积结果显示在4个不同肥胖指标中，VAI(曲线下面积0.662，

0.001)大于BMI、WC及WHR曲线下面积。

结论

VAI是影响糖尿病前期对象转归糖尿病的危险因素，随着VAI增高，糖尿病前期对象转归为糖尿病的风险增高；VAI用于预测糖尿病前期对象5年转归糖尿病的能力优于BMI、腰围及腰臀比。

Abstract

Objective

To investigate the association of visceral adiposity index (VAI) and 5-year outcome of prediabetes development

and compare its predictive value with other anthropometric indices (BMI

waist circumference and waist hip ratio).

Methods

The participants in this cohort study were selected from the epidemiological study of dynamic monitoring of risk factors for type 2 diabetes and integrated community prevention and treatment in Luzhou area from April to November 2011. A total of 1 125 participants with prediabetes were selected from the baseline survey. The subjects were divided into 4 groups according to the quartiles of the VAI (0.37~1.29

1.30~2.01

2.02~3.28

and 3.29~36.12)

and all of them were followed up for 5 years to observe the outcome of prediabetes. Univariate and multivariate logistic regression analyses were used to analyzed the effect of VAI on the outcome

and the areas under the receiver operating characteristic (ROC) curve for VAI

BMI

waist circumference and waist hip ratio were calculated according to different quartiles to determine the predictive power of the indices.

Results

Of the 1 064 participants who completed the follow-up

237 developed to diabetes. In the comparison of the subjects developing into diabetes

statistical differences were seen among the 4 groups

with the 4th quartile group (94 cases)

the 3rd quartile group (68 cases)

the 2nd quartile group (46 cases)

the 1st quartile group (29 cases

Chi

-square=51.566

0.001). Logistic regression analysis showed that after adjustment for any variables and for age

gender

height

systolic blood pressure

triglyceride

high density lipoprotein cholesterol

smoking and tea consumption

the individuals in higher VAI quartile group were more likely to develop to diabetes than those in lower group. The area under the ROC curve for VAI (0.662

0.001) was significantly greater than those of other adiposity indices.

Conclusion

VAI is a risk factor that affects the outcome of prediabetes to diabetes

and may be regarded as a predictor of the outcome. With the increase of VAI

the risk of prediabetes conversion to diabetes increases. VAI is better than BMI

waist circumference and waist hip ratio in predicting the 5-year outcome to diabetes.

关键词

Keywords

references

WANG L M, GAO P, ZHANG M, et al . Prevalence and ethnic pattern of diabetes and prediabetes in China in 2013[J ] . JAMA, 2017, 317(24): 2515-2523. DOI:10.1001/jama.2017.7596.

KARLSSON T, RASK-ANDERSEN M, PAN G, et al . Contribution of genetics to visceral adiposity and its relation to cardiovascular and metabolic disease[J ] . Nat Med, 2019, 25(9): 1390-1395. DOI:10.1038/s41591-019-0563-7.

CASANUEVA F F, MORENO B, RODRIGUEZAZEREDO R, et al . Relationship of abdominal obesity with cardiovascular disease, diabetes and hyperlipidaemia in Spain[J ] . Clin Endocrinol, 2009, 73(1): 35-40. DOI:10.1111/j.1365-2265.2009.03727.x.

SCHLETT C L, HOFFMANN U. Identifikation und quantifizierung von fettkompartimenten mit CT und MRT und deren stellenwert[J]. Der Radiol, 2011, 51(5): 372. DOI:10.1007/s00117-010-2088-4.

WEI J, LIU X, XUE H, et al . Comparisons of visceral adiposity index, body shape index, body mass index and waist circumference and their associations with diabetes mellitus in adults[J ] . Nutrients, 2019, 11(7):1580. DOI: 10.3390/nu11071580.

AHN N, BAUMEISTER S E, AMANN U, et al . Visceral adiposity index (VAI), lipid accumulation product (LAP), and product of triglycerides and glucose (TyG) to discriminate prediabetes and diabetes[J ] . Sci Rep, 2019, 9(1): 9693. DOI:10.1038/s41598-019-46187-8.

中华医学会糖尿病分会.2007年版中国2型糖尿病防治指南[J].中华内分泌代谢杂志, 2008, 24(2):增录1-附录26.

Branch of Diabetes of Chinese Medical Association.2007 edition of Chinese guidelines for the prevention and treatment of type 2 diabetes [J]. Chin J Endocrinol Metab, 2008, 24(2): add.1-26.

AMATO M C, GIORDANO C, GALIA M, et al . Visceral adiposity index: a reliable indicator of visceral fat function associated with cardiometabolic risk[J ] . Diabetes Care, 2010, 33(4): 920-922. DOI:10.2337/dc09-1825.

HUANG T, QI Q B, ZHENG Y, et al . Genetic predisposition to central obesity and risk of type 2 diabetes: two independent cohort studies[J ] . Diabetes Care, 2015, 38(7): 1306-1311. DOI:10.2337/dc14-3084.

KIM J A, HWANG S Y, CHUNG H S, et al . Proportion and characteristics of the subjects with low muscle mass and abdominal obesity among the newly diagnosed and drug-naïve type 2 diabetes mellitus patients[J ] . Diabetes Metab J, 2019, 43(1):105-113. DOI: 10.4093/dmj.2018.0036.

WAKABAYASHI I, DAIMON T. A strong association between lipid accumulation product and diabetes mellitus in Japanese women and men[J]. J Atheroscler Thromb, 2014, 21(3): 282-288. DOI:10.5551/jat.20628.

XING Z H, PEI J Y, HUANG J B, et al . Relationship of obesity to adverse events among patients with mean 10-year history of type 2 diabetes mellitus: results of the ACCORD study[J ] . J Am Heart Assoc, 2018, 7(22): e010512. DOI:10.1161/JAHA.118.010512.

CHEONG K C, GHAZALI S M, HOCK L K, et al . The discriminative ability of waist circumference, body mass index and waist-to-hip ratio in identifying metabolic syndrome: Variations by age, sex and race[J ] . Diabetes Metab Syndr, 2015, 9(2): 74-78. DOI:10.1016/j.dsx.2015.02.006.

ALBRECHT S S, MAYER-DAVIS E, POPKIN B M. Secular and race/ethnic trends in glycemic outcomes by BMI in US adults: The role of waist circumference[J]. Diabetes Metab Res Rev, 2017, 33(5). DOI:10.1002/dmrr.2889.

BALA, MEENAKSHI, AGGARWAL S. Correlation of body mass index and waist/hip ratio with glycated hemoglobin in prediabetes[J]. EJIFCC, 2019, 30(3): 317-324.

HOU X H, CHEN S Y, HU G, et al . Stronger associations of waist circumference and waist-to-height ratio with diabetes than BMI in Chinese adults[J ] . Diabetes Res Clin Pract, 2019, 147: 9-18. DOI:10.1016/j.diabres.2018.07.029.

PAJUNEN P, RISSANEN H, LAAKSONEN M A, et al . Sagittal abdominal diameter as a new predictor for incident diabetes[J ] . Diabetes Care, 2013, 36(2): 283-288. DOI:10.2337/dc11-2451.

CHEN C, XU Y, GUO Z R, et al . The application of visceral adiposity index in identifying type 2 diabetes risks based on a prospective cohort in China[J ] . Lipids Health Dis, 2014, 13:108. DOI: 10.1186/1476-511X-13-108.

WANG Y, HE S, HE J, et al . Predictive value of visceral adiposity index for type 2 diabetes mellitus: a 15-year prospective cohort study[J ] . Herz, 2015, 40(Suppl 3): 277-281. DOI:10.1007/s00059-014-4175-1.

Moon H U, Ha K H, Han S J, et al . The association of adiponectin and visceral fat with insulin resistance and β-cell dysfunction[J ] . J Korean Med Sci, 2018, 34(1):e7.DOI:10.3346/jkms.2019.34.e7.

BALSAN G A, VIEIRA J L D C, OLIVEIRA A M D, et al . Relationship between adiponectin, obesity and insulin resistance[J ] . Rev Assoc Med Bras, 2015, 61(1):72-80. DOI: 10.1590/1806-9282.61.01.072.

UTZSCHNEIDER K M, CARR D B, HULL R L, et al . Impact of intra-abdominal fat and age on insulin sensitivity and beta-cell function[J ] . Diabetes, 2004, 53(11): 2867-2872. DOI:10.2337/diabetes.53.11.2867.

WAGENKNECHT L E, LANGEFELD C D, SCHERZINGER A L, et al . Insulin sensitivity, insulin secretion, and abdominal fat: the Insulin Resistance Atherosclerosis Study (IRAS) family study[J ] . Diabetes, 2003, 52(10): 2490-2496.

MATSUZAWA Y. Establishment of a concept of visceral fat syndrome and discovery of adiponectin[J]. Proc Jpn Acad, Ser Bphys Biol Sci, 2010, 86(2): 131-141. DOI:10.2183/pjab.86.131.

ARITA Y. Reprint of "paradoxical decrease of an adipose-specific protein, adiponectin, in obesity"[J]. Biochem Biophys Res Commun, 2012, 425(3): 560-564. DOI:10.1016/j.bbrc.2012.08.024.

HALLEUX C M, TAKAHASHI M, DELPORTE M L, et al . Secretion of adiponectin and regulation of apM1 gene expression in human visceral adipose tissue[J ] . Biochem Biophys Res Commun, 2001, 288(5): 1102-1107. DOI:10.1006/bbrc.2001.5904.

MAEDA N, TAKAHASHI M, FUNAHASHI T, et al . PPAR ligands increase expression and plasma concentrations of adiponectin, an adipose-derived protein[J ] . Diabetes, 2001, 50(9): 2094-2099. DOI:10.2337/diabetes.50.9.2094.

罗兰, 李欣宇, 高政南.腰围、腰高比、内脏脂肪指数对大连地区40岁以上新诊断糖尿病前期女性患者的预测价值[J].中国糖尿病杂志, 2020, 28(1): 17-22.

LUO L, LI X Y, GAO Z N. The value of waist circumference, waist height ratio and visceral adiposity index in predicting new prediabetes in women over 40 years old in Dalian[J]. Chin J Diabetes, 2020, 28(1): 17-22.

余雪, 李敏谦, 郭姣.内脏脂肪指数与糖脂代谢病的相关性研究[J].世界中医药, 2019, 14(1):29-32, 38.

YU X, LI M Q, GUO J. Correlation between visceral fat index and glycolipid metabolic disease [J]. World J Tradit Chin Med, 2019, 14(1):29-32, 38.

张怡, 王禹盈, 徐文迪, 等.多囊卵巢综合征患者内脏脂肪指数与糖调节受损独立正相关[J].中华糖尿病杂志, 2019, 11(4): 265-269.

ZHANG Y, WANG Y Y, XU W D, et al . Visceral adiposity index is independently and positively related with impaired glucose regulation in women with polycystic ovary syndrome[J ] . Chin J Diabetes Mellit, 2019, 11(4): 265-269.

Views

下载量

CSCD

Alert me when the article has been cited

提交

Tools

Publicity Resources

Regulation and mechanism of Gm49394 on islet-β cell apoptosis

Liraglutide ameliorates cerebral ischemic injury in diabetic rats by regulating microglia/macrophage polarization through inhibition of NOX2 expression

Change of insulin resistance in impaired fasting glucose patients with hypertension: a follow-up study of 5 years

Efficacy and safety of drug-eluting balloon dilatation for coronary bifurcation disease in diabetic patients

Pharmacodynamics of Qihu preparation for treatment of diabetes in mice

Related Author

ZHAO Qingyuan

YANG Shushu

ZHANG Mengjun

LI Jie

LI Yuhao

WANG Li

WU Yuzhang

LIU Dong

Related Institution

Department of Immunology, Faculty of Pharmacy and Laboratory Medicine， Army Medical University （Third Military Medical University）

Department of Laboratory Animal Science， College of Basic Medical Sciences, Faculty of Pharmacy and Laboratory Medicine， Army Medical University （Third Military Medical University）

Department of Pharmaceutical Analysis, Faculty of Pharmacy and Laboratory Medicine， Army Medical University （Third Military Medical University）

Department of Neurology, Fifth Affiliated Hospital (Zhuhai) of Zunyi Medical University

Department of Cardiology, Second Affiliated Hospital of Army Medical University (Third Military Medical University)

⁰