Mitochondrial dynamics in the pathogenesis of diabetic complications

Hongting ZHENG; Hua QU

doi:10.16016/j.1000-5404.202111211

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Mitochondrial dynamics in the pathogenesis of diabetic complications

Clinical Medicine | 更新时间：2026-01-09

- Mitochondrial dynamics in the pathogenesis of diabetic complications
- Journal of Army Medical University Vol. 44, Issue 1, Pages: 64-68(2022)
- 作者机构：
  
  400037 重庆，陆军军医大学（第三军医大学）第二附属医院内分泌科
- 作者简介：
- 基金信息：
  
  the National Science Foundation for Distinguished Young Scholars of China(81925007);the General Program of National Natural Science Foundation of China(82070836)
- DOI：10.16016/j.1000-5404.202111211
  CLC： R329.24;R363.21;R587.2
- Received：29 November 2021，
  
  Revised：2021-12-15，
  
  Published：15 January 2022
- 稿件说明：
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Hongting ZHENG, Hua QU. Mitochondrial dynamics in the pathogenesis of diabetic complications[J]. Journal of Army Medical University, 2022, 44(1): 64-68.
DOI：

Hongting ZHENG, Hua QU. Mitochondrial dynamics in the pathogenesis of diabetic complications[J]. Journal of Army Medical University, 2022, 44(1): 64-68. DOI： 10.16016/j.1000-5404.202111211.

摘要

线粒体动力学（mitochondrial dynamics）即线粒体融合与分裂保持动态平衡的过程。近年来的研究报道，这种动态变化在调控线粒体形态与数量、线粒体氧化代谢、膜电位及能量生成等方面发挥至关重要的作用。当人体罹患糖尿病时，高血糖可显著干扰线粒体融合与分裂的平衡态，影响线粒体数量、形态与功能，最终与多种糖尿病慢性并发症密切相关，但其具体机制尚不明确。本课题组长期致力于探究线粒体动力学在多种糖尿病并发症中的作用与机制。本文就线粒体动力学在糖尿病溃疡、糖尿病肾病以及糖尿病心肌病中的潜在机制及研究进展进行述评。

Abstract

Mitochondrial dynamics is the process of mitochondrial fusion and division to maintain dynamic balance. In recent years

it has been found that this dynamic change plays an important role in regulating mitochondrial morphology and quantity

mitochondrial oxidative metabolism

membrane potential and energy production. In diabetes

hyperglycemia significantly interferes with the dynamic balance of mitochondrial fusion and division process

and affects the quantity

morphology and function of mitochondria. And ultimately

the dynamic change of mitochondria is closely related to many chronic complications of diabetes

but the specific mechanism remains unclear. Our research group has long been committed to exploring the roles and mechanisms of mitochondrial dynamics in a variety of diabetic complications. This review summarizes the research progress and potential mechanisms of mitochondrial dynamics in diabetic ulcers

diabetic nephropathy and diabetic cardiomyopathy.

关键词

Keywords

references

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