Thermo-sensitive TRP channels and prevention of major chronic diseases

Zhiming ZHU; Daoyan LIU

doi:10.16016/j.1000-5404.202111208

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Thermo-sensitive TRP channels and prevention of major chronic diseases

Clinical Medicine | 更新时间：2026-01-09

- Thermo-sensitive TRP channels and prevention of major chronic diseases
- Journal of Army Medical University Vol. 44, Issue 1, Pages: 40-49(2022)
- 作者机构：
  
  400042 重庆，陆军特色医学中心高血压内分泌科，全军高血压与代谢病中心，代谢性血管病重庆市重点实验室，重庆市高血压研究所
- 作者简介：
- 基金信息：
  
  the Innovation Research Group Grant of National Natural Science Foundation of China(81721001)
- DOI：10.16016/j.1000-5404.202111208
  CLC： R339.1;R540.1;R580.1
- Received：29 November 2021，
  
  Revised：2021-12-11，
  
  Published：15 January 2022
- 稿件说明：
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Zhiming ZHU, Daoyan LIU. Thermo-sensitive TRP channels and prevention of major chronic diseases[J]. Journal of Army Medical University, 2022, 44(1): 40-49.
DOI：

Zhiming ZHU, Daoyan LIU. Thermo-sensitive TRP channels and prevention of major chronic diseases[J]. Journal of Army Medical University, 2022, 44(1): 40-49. DOI： 10.16016/j.1000-5404.202111208.

摘要

美国科学家David Julius和Ardem Patapoutian因辣椒素受体TRPV1和薄荷醇感受器TRPM8的突破性发现，揭示了温度感知的奥秘，由此获得了2021年诺贝尔生理学或医学奖。温度敏感性热通道TRPV1和冷通道TRPM8不仅在神经系统有丰富的表达，也存在于心血管、脂肪、肝脏和肌肉等组织器官，但其生物学意义并不清楚。近30年来，研究发现TRPV1和TRPM8除感知环境温度的变化外，还有丰富的生物学效应，如痛觉，炎症反应等，有关瞬时受体电位（transient receptor potential

TRP）通道在机体稳态调控中的作用及其与疾病关联的研究在持续增长与不断深入。我们团队自2004年较早地将TRP通道引入心血管及代谢领域，并揭示其在心血管和代谢疾病中的作用与机制。预期今年的诺奖颁发将进一步推动温度敏感通道蛋白的研究在心血管及代谢领域的发展。

Abstract

American scientists David Julius and Ardem Patapoutian won the Nobel Prize in physiology or medicine in 2021 for their groundbreaking discoveries of capsaicin receptor TRPV1 and menthol receptor TRPM8

revealing the secrets of temperature perception. The outstanding discovery of capsaicin receptor TRPV1 and cold sensitive receptor TRPM8 has deepened our understanding on perception and adapt to the surrounding environment. However

thermal sensitive hot channel TRPV1 and cold channel TRPM8 are not only expressed abundantly in the nervous system

but also exist in the cardiovascular

fat

liver

skeletal muscle and other tissues and organs

and their biological significance remain elusive. In the past 30 years

much evidence shows that TRPV1 and TRPM8 not only perceive changes in environmental temperature

but also have rich biological effects

such as pain sensation

inflammatory response

and so on. Studies concerning the role of transient receptor potential (TRP) channels in the body homeostasis and its association with disease continue to grow and deepen. Since 2004

our team has introduced TRP channels into cardiovascular and metabolic fields and revealed their roles and mechanisms in cardiovascular and metabolic diseases. It is expected that this year's Nobel Prize award will further promote the development of temperature-sensitive channel proteins in cardiovascular and metabolic field.

关键词

Keywords

references

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