Cardiomyocyte proliferation at single-cell resolution

Chunyu ZENG; Wenbin FU

doi:10.16016/j.1000-5404.202111168

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Cardiomyocyte proliferation at single-cell resolution

Basic Medicine | 更新时间：2026-01-09

- Cardiomyocyte proliferation at single-cell resolution
- Journal of Army Medical University Vol. 44, Issue 1, Pages: 69-73(2022)
- 作者机构：
  
  400042 重庆，陆军特色医学中心心血管内科，重庆市心血管病研究所
- 作者简介：
- 基金信息：
  
  the Key Program of National Natural Science Foundation of China(81930008)
- DOI：10.16016/j.1000-5404.202111168
  CLC： R322.11;R329.28;R394.2
- Received：23 November 2021，
  
  Revised：2021-12-07，
  
  Published：15 January 2022
- 稿件说明：
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Chunyu ZENG, Wenbin FU. Cardiomyocyte proliferation at single-cell resolution[J]. Journal of Army Medical University, 2022, 44(1): 69-73.
DOI：

Chunyu ZENG, Wenbin FU. Cardiomyocyte proliferation at single-cell resolution[J]. Journal of Army Medical University, 2022, 44(1): 69-73. DOI： 10.16016/j.1000-5404.202111168.

摘要

单细胞多组学测序技术是在单细胞分辨率下精确分析细胞异质性和基因调控网络的新技术，提供了全新的视角来分析细胞的分化路径、细胞间的交互调控和细胞亚群的分离现象。心肌再生与修复是逆转心肌损伤后重构的重要研究方向。目前，单细胞多组学测序技术已应用于心肌再生领域：构建生理和病理条件下心肌再生图谱，探索心肌细胞增殖的分化路径和非心肌细胞对心肌再生的交互作用，建立全新的连续细胞周期分子标志监测的心肌细胞增殖评价体系以及寻找调控心肌细胞增殖的分子开关等，具有广阔的前景。本述评总结了近几年心肌再生领域的最新研究和进展，探讨单细胞技术在心肌再生领域研究中的应用及今后研究的方向，以期为后续研究提供积极合理的参考。

Abstract

Single-cell multi-omics sequencing is a new technology to accurately analyze cell heterogeneity and gene regulatory network at single-cell resolution

and provides a brand new perspective of pathway analysis on cell differentiation

interaction and heterogeneity. Cardiac regeneration is an important research direction for reversing myocardial injury and remodeling. At present

single-cell omics sequencing technologies have been wildly applied in the field of cardiac regeneration. Great achievements and prospects have been made in the following aspects: landscape of cardiomyocyte proliferation under physiological and pathological conditions; cardiomyocyte differentiation trajectory and interaction of non-cardiomyocytes on cardiac regeneration; new evaluation system for cardiomyocyte proliferation based on consecutively monitoring cell cycle molecular markers; molecular switch regulating cardiomyocyte proliferation. This review summarizes the latest research and progress in the field of cardiac regeneration and discusses the application and development direction of single-cell technologies in the field in order to provide positive and reasonable reference for the future research.

关键词

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references

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