Clinical characteristics of insomnia in perimenopausal women: a clinical study based on polysomnography

Yuan ZHAO; Qingqiu CHEN; Chenggang JIANG

doi:10.16016/j.1000-5404.202103229

您当前的位置：

首页 >

文章列表页 >

Clinical characteristics of insomnia in perimenopausal women: a clinical study based on polysomnography

Neurosciences | 更新时间：2026-01-09

- Clinical characteristics of insomnia in perimenopausal women: a clinical study based on polysomnography
- Journal of Third Military Medical University Vol. 43, Issue 19, Pages: 1854-1859(2021)
- 作者机构：
  
  1.401120 重庆，重庆市妇幼保健院心理科
  2.400038 重庆，陆军军医大学(第三军医大学)第一附属医院乳腺甲状腺外科
- 作者简介：
- 基金信息：
  
  the Project of Technology Innovation and Application Development of Chongqing Science and Technology Commission(cstc2019jscx-msxmX0124)
- DOI：10.16016/j.1000-5404.202103229
  CLC： R338.63;R711.51;R741.044
- Received：27 March 2021，
  
  Revised：2021-04-27，
  
  Published：15 October 2021
- 稿件说明：
移动端阅览
Yuan ZHAO, Qingqiu CHEN, Chenggang JIANG. Clinical characteristics of insomnia in perimenopausal women: a clinical study based on polysomnography[J]. Journal of Third Military Medical University, 2021, 43(19): 1854-1859.
DOI：

Yuan ZHAO, Qingqiu CHEN, Chenggang JIANG. Clinical characteristics of insomnia in perimenopausal women: a clinical study based on polysomnography[J]. Journal of Third Military Medical University, 2021, 43(19): 1854-1859. DOI： 10.16016/j.1000-5404.202103229.

摘要

目的

基于多导睡眠监测探讨围绝经期女性失眠障碍的临床特征及其影响因素。

方法

本研究纳入2020年10月至2021年2月于重庆市妇幼保健院心理科门诊就诊的52名围绝经期女性，根据匹兹堡睡眠指数量表(Pittsburgh Sleep Quality Index

PSQI)结果分为研究组(PSQI≥7分)和对照组(PSQI < 7分)，采用多导睡眠监测(polysomnography，PSG)记录睡眠状况，采用围绝经期评定量表(Menopause Rating Scale

MRS)测量围绝经期相关症状。比较两组PSG监测睡眠相关指标及MRS结果差异，并分析各睡眠指标与围绝经期症状的关系。

结果

① 围绝经期女性研究组睡眠总时间、睡眠效率较对照组明显下降(

0.05)；研究组入睡潜伏期、入睡后清醒时间等指标则明显高于对照组(

0.05)；②围绝经期女性失眠障碍伴有快速眼动(rapid eye movement

REM)期睡眠紊乱的临床特点，与对照组比较，研究组REM睡眠总时间、REM睡眠比例降低，REM睡眠潜伏期延长，REM转清醒次数增加(

0.05)；③研究组MRS总分(26.69±5.13)、躯体症状评分(9.49±2.92)、心理症状评分(10.34±2.95)、泌尿生殖系统评分(6.86±2.89)均高于对照组(

0.05)；④REM睡眠比例、REM睡眠总时间与抑郁情绪呈负相关(

0.05)，REM睡眠潜伏期与焦虑、性生活质量呈正相关(

0.05)。

结论

围绝经期女性失眠障碍表现为REM期睡眠紊乱，且REM期睡眠与焦虑、抑郁及性生活质量密切相关。

Abstract

Objective

To investigate the clinical characteristics and influencing factors of insomnia in perimenopausal women based on polysomnography (PSG).

Methods

A total of 52 perimenopausal women admitted to our psychological clinic due to insomnia were included in this study. According to the results of Pittsburgh sleep quality index (PSQI)

they were divided into study group (PSQI≥7) and control group (PSQI < 7). Sleep status was recorded by polysomnography (PSG)

and symptoms related to perimenopausal period were measured by menopause rating scale (MRS).The differences of PSG monitoring sleep-related indicators and MRS results were compared between the 2 groups

and the correlations of each sleep indicator with perimenopausal symptoms were analyzed.

Results

① The total sleep time and sleep efficiency were significantly decreased in the perimenopausal women from the study group than those from the control group (

0.05). The former group had obviously longer sleep latency and wakefulness time when compared with the latter group (

0.05). ② These perimenopausal women had the clinical feature of rapid eye movement (REM) sleep behavior

which were characterized by decreased total time of REM sleep

decreased proportion of REM sleep

prolonged latency of REM sleep

and increased frequency of REM to wakefulness in the study group when compared with the control group (

0.05). ③The total MRS score

somatic symptom score

psychological symptom score and genitourinary system score were 26.69±5.13

9.49±2.92

10.34±2.95 and 6.86±2.89

respectively

in the study group

which were all higher than those of the control group (

0.05). ④The proportion of REM sleep and the total time of REM sleep were negatively correlated with depression (

0.05)

while the latency of REM sleep was positively correlated with anxiety and sexual life quality (

0.05).

Conclusion

Insomnia in perimenopausal women is characterized by REM sleep disorder

and REM sleep is closely related to anxiety

depression and sexual life quality.

关键词

Keywords

references

SOULES M R, SHERMAN S, PARROTT E, et al . Executive summary: Stages of Reproductive Aging Workshop (STRAW)[J ] . Climacteric, 2001, 4(4): 267-272.

MONTELEONE P, MASCAGNI G, GIANNINI A, et al . Symptoms of menopause-global prevalence, physiology and implications[J ] . Nat Rev Endocrinol, 2018, 14(4): 199-215. DOI:10.1038/nrendo.2017.180.

徐曌旭, 张会君. 围绝经期女性焦虑情绪在睡眠障碍与生活质量间的中介效应[J]. 中华行为医学与脑科学杂志, 2019, 28(7): 592-596. DOI: 10.3760/cma.j.issn.1674-6554.2019.07.004.

XU Z X, ZHANG H J. Mediating effect of anxiety between sleep disturbance and quality of life in perimenopausal women[J]. Chin J Behav Med Brain Sci, 2019, 28(7): 592-596. DOI: 10.3760/cma.j.issn.1674-6554.2019.07.004.

HARLOW S D, GASS M, HALL J E, et al . Executive summary of the Stages of Reproductive Aging Workshop+10: addressing the unfinished agenda of staging reproductive aging[J ] . Menopause, 2012, 19(4): 387-395. DOI:10.1097/gme.0b013e31824d8f40.

WOODS N F, MITCHELL E S. Symptoms during the perimenopause: prevalence, severity, trajectory, and significance in women's lives[J]. Am J Med, 2005, 118(12): 14-24. DOI:10.1016/j.amjmed.2005.09.031.

HALE G E, HUGHES C L, BURGER H G, et al . Atypical estradiol secretion and ovulation patterns caused by luteal out-of-phase (LOOP) events underlying irregular ovulatory menstrual cycles in the menopausal transition[J ] . Menopause, 2009, 16(1): 50-59. DOI:10.1097/GME.0b013e31817ee0c2.

林坦, 吴青, 刘越. 围绝经期妇女更年期症状与睡眠质量的关系探讨[J]. 世界睡眠医学杂志, 2018, 5(12): 1443-1445.

LIN T, WU Q, LIU Y. Study on the relationship between climacteric symptoms and sleep quality in perimenopausal women[J]. World J Sleep Med, 2018, 5(12): 1443-1445.

DENNERSTEIN L, DUDLEY E C, HOPPER J L, et al . A prospective population-based study of menopausal symptoms[J ] . Obstet Gynecol, 2000, 96(3): 351-358. DOI:10.1016/s0029-7844(00)00930-3.

BROWN W J, MISHRA G D, DOBSON A. Changes in physical symptoms during the menopause transition[J]. Int J Behav Med, 2002, 9(1): 53-67. DOI:10.1207/s15327558ijbm0901_04.

SHAVER J L, WOODS N F. Sleep and menopause: a narrative review[J]. Menopause, 2015, 22(8): 899-915. DOI:10.1097/GME.0000000000000499.

HE C, HU Z A, JIANG C G. Sleep disturbance: an early sign of Alzheimer's disease[J]. Neurosci Bull, 2020, 36(4): 449-451. DOI:10.1007/s12264-019-00453-x.

KRAVITZ H M, GANZ P A, BROMBERGER J, et al . Sleep difficulty in women at midlife: a community survey of sleep and the menopausal transition[J ] . Menopause, 2003, 10(1): 19-28. DOI:10.1097/00042192-200310010-00005.

KRAVITZ H M, ZHAO X H, BROMBERGER J T, et al . Sleep disturbance during the menopausal transition in a multi-ethnic community sample of women[J ] . Sleep, 2008, 31(7): 979-990.

TERASHIMA K, MIKAMI A, TACHIBANA N, et al . Sleep characteristics of menop ausal insomnia: a polysomnographic study[J ] . Psychiatry Clin Neurosci, 2004, 58(2): 179-185. DOI:10.1111/j.1440-1819.2003.01214.x.

SCHWARTZ M D, MONG J A. Estradiol modulates recovery of REM sleep in a time-of-day-dependent manner[J]. Am J Physiol Regul Integr Comp Physiol, 2013, 305(3): R271-R280. DOI:10.1152/ajpregu.00474.2012.

PEEVER J, FULLER P M. The biology of REM sleep[J]. Curr Biol, 2017, 27(22): R1237-R1248. DOI:10.1016/j.cub.2017.10.026.

OHAYON M M. Severe hot flashes are associated with chronic insomnia[J]. Arch Intern Med, 2006, 166(12): 1262-1268. DOI:10.1001/archinte.166.12.1262.

BAKER F C, FOROUZANFAR M, GOLDSTONE A, et al . Changes in heart rate and blood pressure during nocturnal hot flashes associated with and without awakenings[J ] . Sleep, 2019, 42(11): zsz175. DOI:10.1093/sleep/zsz175.

HORVÁTH A, MONTANA X, LANQUART J P, et al . Effects of state and trait anxiety on sleep structure: a polysomnographic study in 1083 subjects[J ] . Psychiatry Res, 2016, 244: 279-283. DOI:10.1016/j.psychres.2016.03.001.

GALLICCHIO L, WHITEMAN M K, TOMIC D, et al . Type of menopause, patterns of hormone therapy use, and hot flashes[J ] . Fertil Steril, 2006, 85(5): 1432-1440. DOI:10.1016/j.fertnstert.2005.10.033.

SAVOLAINEN-PELTONEN H, HAUTAMÄKI H, TUOMIKOSKI P, et al . Health-related quality of life in women with or without hot flashes: a randomized placebo-controlled trial with hormone therapy[J ] . Menopause N Y N Y, 2014, 21(7): 732-739. DOI:10.1097/GME.0000000000000120.

WELTON A J, VICKERS M R, KIM J, et al . Health related quality of life after combined hormone replacement therapy: randomised controlled trial[J ] . Br Med J, 2008, 337: a1190. DOI:10.1136/bmj.a1190.

DZAJA A, ARBER S, HISLOP J, et al . Women's sleep in health and disease[J ] . J Psychiatr Res, 2005, 39(1): 55-76. DOI:10.1016/j.jpsychires.2004.05.008.

SCHWARTZ M D, MONG J A. Estradiol suppresses recovery of REM sleep following sleep deprivation in ovariectomized female rats[J]. Physiol Behav, 2011, 104(5): 962-971. DOI:10.1016/j.physbeh.2011.06.016.

Views

下载量

CSCD

Alert me when the article has been cited

提交

Tools

Publicity Resources

基于CT影像组学特征联合临床特征预测非小细胞肺癌EGFR突变状态

Efficacy and clinical outcomes of different antiviral regimens in HBeAg/HBeAb double-positive patients with chronic hepatitis B

Clinical characteristics of coronavirus disease 2019 in a Chongqing hospital: analysis of 89 cases

Clinical characteristics of pulmonary large cell neuroendocrine carcinoma and a nomogram model for predicting its prognosis

Clinical characteristics and mutation spectrum of the pathogenic gene ATP7B in Chinese patients with Wilson's disease: analysis of 119 cases

Related Author

WANG Xianqi

CHEN Cancan

YAN Wanying

WANG Dawei

XIONG Kunlin

SUN Zhiyuan

CHEN Wei

YANG Taotao

Related Institution

Department of Hepatology, Affiliated Three Gorges Hospital of Chongqing University

Department of Hepatobiliary Surgery, First Affiliated Hospital, Army Medical University (Third Military Medical University)

Department of Geriatrics, Yongchuan Hospital of Chongqing Medical University

Ward of Geriatrics and Novel Coronavirus Pneumonia, Yongchuan Hospital of Chongqing Medical University

⁰