Diagnosis and treatment of botulism after botulinum toxin type A injections: report of 9 cases
- Journal of Third Military Medical University Vol. 43, Issue 17, Pages: 1684-1688(2021)
- 作者机构：
- 作者简介：
- 基金信息：the Joint Medical Research Project of Chongqing Science and Technology Commission and Chongqing Health Commission(2019MSXM013)
DOI：10.16016/j.1000-5404.202103069
CLC：Received：07 March 2021，
Published：15 September 2021
- 稿件说明：
移动端阅览
Ping HE, Jianghe ZHANG, Rongshuai YAN, et al. Diagnosis and treatment of botulism after botulinum toxin type A injections: report of 9 cases[J]. Journal of Third Military Medical University, 2021, 43(17): 1684-1688.
Ping HE, Jianghe ZHANG, Rongshuai YAN, et al. Diagnosis and treatment of botulism after botulinum toxin type A injections: report of 9 cases[J]. Journal of Third Military Medical University, 2021, 43(17): 1684-1688. DOI： 10.16016/j.1000-5404.202103069.
摘要
目的
2
探讨注射性A型肉毒素中毒的诊断指标及肉毒抗毒素对其治疗的效果。
方法
2
收集2018年8月至2020年12月本科收治的9例A型肉毒素中毒患者临床资料
包括血液实验室检查、电生理检查、眼科检查等结果
并分析肉毒抗毒素（A型）综合治疗效果。
结果
2
肉毒素中毒患者外周血液涂片可发现中性粒细胞胞内出现中毒颗粒；电生理检查有1例出现面神经运动传导潜伏时延长
1例出现三叉神经诱发电位延长
2例出现重复电刺激衰减
1例出现视觉诱发电位延长；眼科检查有2例复视图阳性
2例眼睑板腺检查部分缺失。9例患者经过肉毒抗毒素治疗
恢复情况良好。
结论
2
结合临床表现
全面的血液实验室检查、电生理检查及眼科检查有助于肉毒素中毒的早期诊断
对确诊肉毒素中毒患者应尽快使用肉毒抗毒素治疗。
Abstract
Objective
2
To explore the diagnostic criteria of botulism after botulinum toxin type A (BT/A) injection and observe the therapeutic effect of botulinum antitoxin.
Methods
2
From August 2018 to June 2020
9 patients suffering from botulism after BT/A injection admitted to our department were enrolled in this study. They all received blood laboratory examinations
electrophysiological examination
ophthalmological examination and so on
and then
were treated with botulinum antitoxin (type A).
Results
2
Toxic granules in the neutrophils were found in the peripheral blood smears of these patients. The results of electrophysiological examination showed that there were prolongation of motor nerve conduction velocity (MCV) in 1 patient
prolongation of trigeminal somatosensory evoked potential (TSEP) in 1 patient
attenuation of repetitive nerve stimulation (RNS) in 2 patients and prolongation of visual evoked potential (VEP) in 1 patient. In ophthalmological examination
the double view was positive in 2 cases
and the eyelid plate gland was less in 2 cases. Nine patients were treated with botulinum antitoxin and recovered well after that.
Conclusion
2
Combined with clinical manifestations
comprehensive blood laboratory examinations
electrophysiological examination and ophthalmological examination are helpful for the early diagnosis and elimination of botulism. Patients with confirmed botulinum should be treated with botulinum antitoxin as soon as possible.
关键词
Keywords
references
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