Evaluative value of peripheral blood leukocyte counts on disorders of consciousness in patients with acute cerebral infarction

Dongmei WU; Debin LU; Yuqin LI; Yanling HUANG; Zhi HU; Zhongxiang YAO; Yan ZHANG

doi:10.16016/j.1000-5404.202102110

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Evaluative value of peripheral blood leukocyte counts on disorders of consciousness in patients with acute cerebral infarction

Clinical Medicine | 更新时间：2026-01-09

- Evaluative value of peripheral blood leukocyte counts on disorders of consciousness in patients with acute cerebral infarction
- Journal of Third Military Medical University Vol. 43, Issue 16, Pages: 1575-1580(2021)
- 作者机构：
  
  1.400010 重庆，重庆医科大学附属第二医院神经内科
  2.400062 重庆，中国科学院大学重庆仁济医院(重庆市第五人民医院)内分泌科
  3.400014 重庆，重庆大学附属中心医院(重庆市急救医疗中心)神经内科
  4.400038 重庆，陆军军医大学(第三军医大学)基础医学院生理学教研室
  5.401420 重庆，重庆市綦江区人民医院神经内科
- 作者简介：
- 基金信息：
  
  the Fund for Creative Research Groups of National Natural Science Foundation of China(31921003)
- DOI：10.16016/j.1000-5404.202102110
  CLC： R446.113;R743.3;R749.13
- Received：22 February 2021，
  
  Revised：2021-04-27，
  
  Published：30 August 2021
- 稿件说明：
移动端阅览
Dongmei WU, Debin LU, Yuqin LI, et al. Evaluative value of peripheral blood leukocyte counts on disorders of consciousness in patients with acute cerebral infarction[J]. Journal of Third Military Medical University, 2021, 43(16): 1575-1580.
DOI：

Dongmei WU, Debin LU, Yuqin LI, et al. Evaluative value of peripheral blood leukocyte counts on disorders of consciousness in patients with acute cerebral infarction[J]. Journal of Third Military Medical University, 2021, 43(16): 1575-1580. DOI： 10.16016/j.1000-5404.202102110.

摘要

目的

探讨急性脑梗死患者外周血白细胞、中性粒细胞、淋巴细胞水平对意识障碍程度的评估价值。

方法

从2018年1~12月在重庆大学附属中心医院住院的急性脑梗死患者中筛选出136例，按入院时格拉斯哥昏迷指数(Glasgow coma scale

GCS)分为意识障碍组(GCS ≤ 14分，

=59)与无意识障碍组(GCS=15分，

=77)，比较两组间外周血白细胞绝对值、中性粒细胞绝对值与百分比、淋巴细胞绝对值与百分比、中性粒细胞/淋巴细胞比值，以及常见血管危险因素(年龄、性别、高血压、糖尿病、房颤、高脂血症)的差异。在意识障碍组中分别比较上述外周血指标与GCS评分的关联性。

结果

意识障碍组外周血白细胞绝对值、中性粒细胞绝对值和百分比、房颤患者比例均显著高于无意识障碍组，而淋巴细胞绝对值和百分比、中性粒细胞/淋巴细胞比值、年龄、性别以及高血压、糖尿病、高脂血症病史差异均无统计学意义。此外，意识障碍组外周血白细胞绝对值、中性粒细胞绝对值和百分比越高，则GCS评分越低，二者呈负相关。运用协方差分析分别校正了房颤以及其他血管危险因素后，以上负相关仍然存在。

结论

急性脑梗死患者外周血白细胞、中性粒细胞绝对值和百分比升高与意识障碍GCS评分降低密切相关。

Abstract

Objective

To investigate the evaluative values of peripheral blood leukocyte

neutrophil and lymphocyte counts on disorders of consciousness (DOC) in patients with acute cerebral infarction.

Methods

A total of 136 patients with acute cerebral infarction admitted to the Affiliated Central Hospital of Chongqing University from January to December 2018 were selected in this study. According to Glasgow coma scale (GCS) at admission

they were divided into DOC group (GCS≤14

n=59) and non-DOC group (GCS=15

=77). The absolute values of peripheral blood leukocyte count and neutrophil count

percentage of neutrophils

absolute value of lymphocytes

percentage of lymphocytes

neutrophil/lymphocyte ratio

and common vascular risk factors (such as age

gender

hypertension

diabetes

atrial fibrillation and hyperlipidemia) were compared between the 2 groups. In addition

the relationships between the above peripheral blood indexes and GCS score were analyzed in the DOC group.

Results

The absolute values of leukocytes and neutrophils

percentage of neutrophils and proportion of patients with atrial fibrillation were significantly higher in the DOC group than the non-DOC group

but there were no statistical differences in the absolute value of lymphocytes

percentage of lymphocytes

neutrophil/lymphocyte ratio

age

gender

history of hypertension

diabetes and hyperlipidemia between the 2 groups. In addition

the absolute values of leukocytes and neutrophils and percentage of neutrophils in peripheral blood were negatively correlated with GCS scores. The higher the above 3 indexes were

the lower the GCS scores were. After adjustment for atrial fibrillation and other vascular risk factors by analysis of covariance

the above negative correlations still existed.

Conclusion

The absolute values of peripheral blood leukocytes and neutrophils

and percentage of neutrophils are closely associated with decreased GCS score in acute cerebral infarction patients.

关键词

Keywords

references

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