Efficacy of sonophoresis vitamin E on postinflammatory hyperpigmentation after facial second degree burn: a short-term analysis

Ruqian YANG; Xue WANG; Yuting YANG; Qin YANG; Xing LUO; Xinli TIAN; Hong YAN

doi:10.16016/j.1000-5404.202101072

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Efficacy of sonophoresis vitamin E on postinflammatory hyperpigmentation after facial second degree burn: a short-term analysis

Monographic Reports: Studies on skin wound and scar repair | 更新时间：2026-01-09

- Efficacy of sonophoresis vitamin E on postinflammatory hyperpigmentation after facial second degree burn: a short-term analysis
- Journal of Third Military Medical University Vol. 43, Issue 11, Pages: 1039-1044(2021)
- 作者机构：
  
  646000 四川泸州，西南医科大学附属医院整形烧伤外科，国家临床重点建设专科，创面修复与再生实验室
- 作者简介：
- 基金信息：
- DOI：10.16016/j.1000-5404.202101072
  CLC： R364.23;R644;R977.25
- Received：08 January 2021，
  
  Revised：2021-03-10，
  
  Published：15 June 2021
- 稿件说明：
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Ruqian YANG, Xue WANG, Yuting YANG, et al. Efficacy of sonophoresis vitamin E on postinflammatory hyperpigmentation after facial second degree burn: a short-term analysis[J]. Journal of Third Military Medical University, 2021, 43(11): 1039-1044.
DOI：

Ruqian YANG, Xue WANG, Yuting YANG, et al. Efficacy of sonophoresis vitamin E on postinflammatory hyperpigmentation after facial second degree burn: a short-term analysis[J]. Journal of Third Military Medical University, 2021, 43(11): 1039-1044. DOI： 10.16016/j.1000-5404.202101072.

摘要

目的

观察超声波导入维生素E对面部Ⅱ度烧伤后色素沉着的治疗效果。

方法

招募2019年9月至2020年9月在本院就诊的面部Ⅱ度烧伤患者36例，观察组(

=12)和对照组(

=12)患者通过随机抽样法进行分组，另有12例拒绝进行治疗的患者作为未处理组。观察组使用超声波(频率1 MHz，强度0.8 W/cm

，2次/d)导入维生素E(0.5~1 mL，2次/d)治疗面部色素沉着，2周为1个疗程；对照组仅外用涂抹维生素E；未处理组面部皮肤不做处理。3组患者面部皮肤均严格进行物理防晒，于治疗2、4周后观察疗效。

结果

治疗2周后，观察组总有效率为83.33%，高于对照组(66.67%)和未处理组(8.33%)，3组治疗总有效率差异有统计学意义(

=0.001)；治疗4周后，观察组和对照组总有效率均为83.33%，高于未处理组(25.00%)，3组治疗总有效率差异有统计学意义(

=0.011)。观察组患者治疗2、4周后色素面积和色素强度减轻程度均明显高于对照组和未处理组(

0.05)，对照组明显高于未处理组(

0.05)。随着时间的增加，3组患者色素面积和色素强度均呈减轻趋势，其中对照组治疗4周后患者色素面积和色素强度减轻程度明显高于2周(

0.05)，而观察组患者治疗2周即达到对照组治疗4周的效果(

0.05)。

结论

超声波导入维生素E可有效改善面部烧伤形成的炎症后色素沉着，缩短见效时间。

Abstract

Objective

To observe the therapeutic effect of sonophoresis vitamin E on postinflammatory hyperpigmentation after facial second degree burn.

Methods

All the 36 patients with facial second degree treated in our hospital between September 2019 and September 2020 were recruited in this study. Twenty-four of them were randomly assigned into the observation group (

=12) and the control group (

=12)

and the other 12 who refused treatment were automatically assigned to the blank control group (

=12). The observation group was treated with vitamin E (0.5~1 mL

twice per day) by sonophoresis (frequency 1 MHz

intensity 0.8 W/cm

twice per day)

while the control group was only treated with vitamin E

and the blank control group was not treated with vitamin E. And the 3 groups of patients followed strictly physical sunscreen for facial skin. After 2 and 4 weeks of treatment

the curative effects were observed and compared among the 3 groups.

Results

After 2 weeks

the total effective rate was 83.33% in the observation group

66.67% in the control group

and 8.33% in the blan

k control group; And significant difference in the rate was observed among the 3 groups (

=0.001). In 4 weeks after treatment

the total effective rate was 83.33% in both the observation group and the control group

obviously higher than that of the blank control group (25.00%

=0.011). The observation group obtained less pigment area and weaker pigment intensity when compared the other 2 groups in 2 and 4 weeks after treatment (

0.05)

and the conditions in the pigmentation were better in the control group than the blank control group (

0.05). With time elapsing

the pigment area and pigment intensity were in a trend of decreasing in all of the 3 groups. The conditions after 4 weeks' treatment were greatly improved than those at 2 weeks in the control group (

0.05). Those at 2 weeks in the observation group were similar to those in the control group after 4 weeks' treatment (

0.05).

Conclusion

Vitamin E though sonophoresis can effectively improve the postinflammatory hyperpigmentation and shorten the effective time for facial burn.

关键词

Keywords

references

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