Correlation between peripheral blood inflammatory factors and quality of life in patients with atrial fibrillation

Zhiquan YUAN; Huan ZHANG; Na WU; Xinghua CHEN; Ying XIANG; Xiaoyue JIA; Chengying LI; Long WU; Zhihui ZHANG; Li ZHONG; Yafei LI

doi:10.16016/j.1000-5404.202012222

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Correlation between peripheral blood inflammatory factors and quality of life in patients with atrial fibrillation

Public Health and Preventive Medicine | 更新时间：2026-01-09

- Correlation between peripheral blood inflammatory factors and quality of life in patients with atrial fibrillation
- Journal of Third Military Medical University Vol. 43, Issue 13, Pages: 1286-1292(2021)
- 作者机构：
  
  1.400038 重庆，陆军军医大学(第三军医大学): 军事预防医学系军队流行病学教研室
  2.400038 重庆，陆军军医大学(第三军医大学): 第一附属医院心血管内科
  3.401120 重庆，重庆医科大学附属第三医院心血管疾病中心
- 作者简介：
- 基金信息：
  
  the National Natural Science Foundation for Young Scholars of China(81502883)
- DOI：10.16016/j.1000-5404.202012222
  CLC： R181.37;R446.112;R541.75
- Received：28 December 2020，
  
  Revised：2021-03-27，
  
  Published：15 July 2021
- 稿件说明：
移动端阅览
Zhiquan YUAN, Huan ZHANG, Na WU, et al. Correlation between peripheral blood inflammatory factors and quality of life in patients with atrial fibrillation[J]. Journal of Third Military Medical University, 2021, 43(13): 1286-1292.
DOI：

Zhiquan YUAN, Huan ZHANG, Na WU, et al. Correlation between peripheral blood inflammatory factors and quality of life in patients with atrial fibrillation[J]. Journal of Third Military Medical University, 2021, 43(13): 1286-1292. DOI： 10.16016/j.1000-5404.202012222.

摘要

目的

调查房颤患者生活质量，探究外周血炎症因子与房颤患者生活质量的关联。

方法

连续纳入2013年12月至2015年7月在陆军军医大学第一附属医院心血管内科住院的新发非瓣膜性房颤患者258例。在患者初次住院时检测外周血常规炎症因子C反应蛋白(C-reactive protein，CRP)、血清白蛋白(albumin，ALB)、血小板淋巴细胞比值(platelet to lymphocyte ratio，PLR)、中性粒细胞淋巴细胞比值(neutrophil to lymphocyte ratio，NLR)、淋巴细胞单核细胞比值(lymphocyte to monocyte ratio，LMR)、D-二聚体(D-dimer)，采用房颤生活质量量表(Atrial Fibrillation Effect on Quality of Life，AFEQT)收集患者生活质量数据，运用Spearman相关和偏相关分析外周血炎症因子与生活质量的关联。

结果

230例完成房颤患者生活质量随访调查。不同年龄、性别、文化程度、吸烟史、饮酒史、他汀药物史、高血压史或糖尿病史等合并症的房颤患者生活质量总评分差异具有统计学意义(

0.05)。Spearman相关分析发现D-二聚体与症状维度评分呈负相关(

0.05)，D-二聚体、NLR与日常活动评分及总评分呈负相关(

0.05)，LMR与日常活动评分及总评分呈正相关。偏相关分析调整混杂因素后，结果显示D-二聚体与房颤患者日常活动评分呈负相关(

=-0.136，

=0.044)。

结论

D-二聚体水平升高的房颤患者日常活动能力较低，可能影响房颤患者的生活质量。

Abstract

Objective

To investigate the quality of life in patients with atrial fibrillation (AF) and to analyze its correlation with peripheral blood inflammatory factors.

Methods

A total of 258 patients with new-onset non-valvular AF who were admitted to the Department of Cardiology of the First Affiliated Hospital of Army Medical University from December 2013 to July 2015 were enrolled consecutively. The peripheral blood inflammatory factors

including C-reactive protein (CRP)

albumin (ALB) and D-dimer

and platele to lymphocyte ratio (PLR)

neutrophil to lymphocyte ratio (NLR) and lymphocyte to monocyte ratio (LMR) were detected and calculated at admission. Atrial Fibrillation Effect on Quality of Life (AFEQT) questionnaire was adopted to assess the quality of life of these patients. Spearman correlation and partial correlation were used to analyze the correlation between peripheral blood inflammatory factors and quality of life.

Results

The correlation between the overall quality of life score and baseline variables such as age

gender

educational level

smoking

drinking

taking statins

history

of hypertension or diabetes was statistically significant among the 230 patients who completed the questionaire about quality of life (

0.05). Spearman correlation analysis showed that D-dimer was negatively correlated with symptom scores (

0.05)

and D-dimer and NLR were negatively while LMR positively correlated with daily activity scores and overall scores (

0.05). After adjustiment of confounders

the partial correlation analysis represented a negative correlation between D-dimer and daily activity scores in the patients (

=-0.136

=0.044).

Conclusion

Elevated D-dimer level suggests lower ability to perform daily activities in AF patients

and may affect their quality of life.

关键词

Keywords

references

IKEMURA N, SPERTUS J A, KIMURA T, et al . Cohort profile: patient characteristics and quality-of-life measurements for newly-referred patients with atrial fibrillation-Keio interhospital Cardiovascular Studies-atrial fibrillation (KiCS-AF)[J ] . BMJ Open, 2019, 9(12): e032746. DOI:10.1136/bmjopen-2019-032746.

GUO Y, LIP G Y, APOSTOLAKIS S. Inflammation in atrial fibrillation[J]. J Am Coll Cardiol, 2012, 60(22): 2263-2270. DOI:10.1016/j.jacc.2012.04.063.

WU N, CHEN X, CAI T, et al . Association of inflammatory and hemostatic markers with stroke and thromboembolic events in atrial fibrillation: a systematic review and meta-analysis[J ] . Can J Cardiol, 2015, 31(3): 278-286. DOI:10.1016 /j.cjca.2014.12.002.

OKUMURA Y. Inflammatory biomarkers in atrial fibrillation: are they linked to future outcomes?[J]. Heart Br Cardiac Soc, 2016, 102(7): 487-489. DOI:10.1136/heartjnl-2015-309079.

PAQUISSI F C. The predictive role of inflammatory biomarkers in atrial fibrillation as seen through neutrophil-lymphocyte ratio mirror[J]. J Biomark, 2016, 2016: 8160393. DOI:10.1155/2016/8160393.

张欢, 钟理, 陈兴华, 等. 房颤特异性生活质量量表的汉化和信效度评价[J]. 现代预防医学, 2020, 47(3): 471-473, 478.

ZHANG H, ZHONG L, CHEN X H, et al . The chinesization of atrial fibrillation effect on quality-of-life questionnaire and its reliability and validity[J ] . Mod Prev Med, 2020, 47(3): 471-473, 478.

CAMM A J, KIRCHHOF P, LIP G Y, et al . Guidelines for the management of atrial fibrillation: the task force for the management of atrial fibrillation of the European Society of Cardiology (ESC)[J ] . Eur Heart J, 2010, 31(19): 2369-2429. DOI:10.1093/eurheartj/ehq278.

中国肥胖问题工作组. 中国成人超重和肥胖症预防与控制指南(节录)[J]. 营养学报, 2004, 26 (1): 1-4. DOI:10.13325/j.cnki.acta.nutr.sin.2004.01.001.

Working Group on Obesity in China. Guidelines for the prevention and control of overweight and obesity in Chinese adults(Excerpt)[J]. Acta Nutr Sin, 2004, 26 (1): 1-4. DOI:10.13325/j.cnki.acta.nutr.sin.2004.01.001.

何权瀛, 高莹慧. 关于吸烟问题若干名词定义[J]. 中华结核和呼吸杂志, 2009, 32(1): 26. DOI:10.3760/cma.j.issn.1001-0939.2009.01.008.

HE Q Y, GAO Y H. Definition of several terms on smoking[J]. Chin J Tuberc Respir Dis, 2009, 32(1): 26. DOI:10.3760/cma.j.issn.1001-0939.2009.01.008.

马冠生, 朱丹红, 胡小琪, 等. 中国居民饮酒行为现况[J]. 营养学报, 2005, 27(5): 16-19. DOI:10.13325/j.cnki.acta.nutr.sin.2005.05.003.

MA G S, ZHU D H, HU X Q, et al . The drinking practice of people in China[J ] . Acta Nutrimenta Sinica, 2005, 27 (5): 16-19. DOI:10.13325/j.cnki.acta.nutr.sin.2005.05.003.

MOQEEM K, BEEHARRY M W, FANG T, et al . Factors influencing sex-related differences in the quality of life of patients with atrial fibrillation: a systematic review[J ] . Cureus, 2020, 12(12): e12341. DOI: 10.7759/cureus.12341.

WANG L, WANG C, WANG J F, et al . A novel systemic immune-inflammation index predicts survival and quality of life of patients after curative resection for esophageal squamous cell carcinoma[J ] . J Cancer Res Clin Oncol, 2017, 143(10): 2077-2086. DOI:10.1007/s00432-017-2451-1.

LAIRD B J A, FALLON M, HJERMSTAD M J, et al . Quality of life in patients with advanced cancer: differential association with performance status and systemic inflammatory response[J ] . J Clin Oncol, 2016, 34(23): 2769-2775. DOI:10.1200/JCO.2015.65.7742.

WU L, EMMENS R W, VAN WEZENBEEK J, et al . Atrial inflammation in different atrial fibrillation subtypes and its relation with clinical risk factors[J ] . Clin Res Cardiol, 2020, 109(10): 1271-1281. DOI: 10.1007/s00392-020-01619-8.

MUKAMAL K J, TOLSTRUP J S, FRIBERG J, et al . Fibrinogen and albumin levels and risk of atrial fibrillation in men and women (the Copenhagen City Heart Study)[J ] . AM J Cardiol, 2006, 98(1): 75-81. DOI:10.1016/j.amjcard.2006.01.067.

LI Q Q, LU Z H, YANG L, et al . Neutrophil count and the inflammation-based glasgow prognostic score predict survival in patients with advanced gastric cancer receiving first-line chemotherapy[J ] . Asian Pac J Cancer Prev, 2014, 15(2): 945-950. DOI:10.7314/apjcp.2014.15.2.945.

WEITZ J I, FREDENBURGH J C, EIKELBOOM J W, et al . A Test in Context: D-Dimer[J ] . J Am Coll Cardiol, 2017, 70(19): 2411-2420. DOI: 10.1016/j.jacc.2017.09.024.

SIEGBAHN A, OLDGREN J, ANDERSSON U, et al . D-dimer and factor Ⅶa in atrial fibrillation—prognostic values for cardiovascular events and effects of anticoagulation therapy. A RE-LY substudy[J ] . Thromb Haemost, 2016, 115(5): 921-930. DOI:10.1160/TH15-07-0529.

GUNGOR H, BABU A S, ZENCIR C, et al . Association of preoperative patelet-to-lymphocyte ratio with atrial fibrillation after coronary artery bypass graft surgery[J ] . Med Princ Pract, 2017, 26(2): 164-168. DOI:10.1159/000453614.

YAYLA Ç, AKBOǦ A M K, GAYRETLI YAYLA K, et al . A novel marker of inflammation in patients with slow coronary flow: lymphocyte-to-monocyte ratio[J ] . Biomark Med, 2016, 10(5): 485-493. DOI:10.2217/bmm-2016-0022.

GIBSON P H, CUTHBERTSON B H, CROAL B L, et al . Usefulness of neutrophil/lymphocyte ratio as predictor of new-onset atrial fibrillation after coronary artery bypass grafting[J ] . Am J Cardiol, 2010, 105(2): 186-191. DOI:10.1016/j.amjcard.2009.09.007.

SHAO Q, CHEN K, RHA S W, et al . Usefulness of neutrophil/lymphocyte ratio as a predictor of atrial fibrillation: a meta-analysis[J ] . Arch Med Res, 2015, 46(3): 199-206. DOI:10.1016/j.arcmed.2015.03.011

BEATON D E, BOMBARDIER C, GUILLEMIN F, et al . Guidelines for the process of cross-cultural adaptation of self-report measures[J ] . Spine (Phila Pa 1976), 2000, 25(24): 3186-3191. DOI:10.1097/00007632-200012150-00014.

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