Prediction model and application value of lysophosphatidylcholine in evaluation for donor liver quality

Hong WANG; Yanjiao OU; Peng HU; Wei LIU; Chuanhong LI; Leida ZHANG

doi:10.16016/j.1000-5404.202011216

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Prediction model and application value of lysophosphatidylcholine in evaluation for donor liver quality

更新时间：2026-01-09

- Prediction model and application value of lysophosphatidylcholine in evaluation for donor liver quality
- Journal of Third Military Medical University Vol. 43, Issue 6, Pages: 512-521(2021)
- 作者机构：
- 作者简介：
- 基金信息：
  
  the key Project of Technology Innovation and Application Demonstration of Chongqing(Social and People's Livelihood)(cstc2018jscx-mszdX0016)
- DOI：10.16016/j.1000-5404.202011216
  CLC：
- Received：23 November 2020，
  
  Published：30 March 2021
- 稿件说明：
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Hong WANG, Yanjiao OU, Peng HU, et al. Prediction model and application value of lysophosphatidylcholine in evaluation for donor liver quality[J]. Journal of Third Military Medical University, 2021, 43(6): 512-521.
DOI：

Hong WANG, Yanjiao OU, Peng HU, et al. Prediction model and application value of lysophosphatidylcholine in evaluation for donor liver quality[J]. Journal of Third Military Medical University, 2021, 43(6): 512-521. DOI： 10.16016/j.1000-5404.202011216.

摘要

Abstract

Objective

To explore the alteration profile of lysophosphatidylcholine (LPC) content in donor liver with the elapse of total ischemic time and investigate its application value in the evaluation of donor liver quality.

Methods

A total of 100 patients who underwent liver transplantation in our hospital from June 2018 to August 2020 were enrolled in this study. Donor liver samples were collected respectively at the moment of donor liver acquisition (group A) and after reperfusion (group B). Pathomorphological scoring was performed and the tissue content of LPC was detected. The incidence of early allograft dysfunction (EAD) was used as a grouping variable. The efficacy of LPC in the evaluation of the quality of donor liver was analyzed.

Results

The tissue concentration of LPC in the liver samples of both group A and B was significantly higher in EAD group than non-EAD group (

0.05)

and the concentration was higher in group B than group A. The LPC concentration in group B showed a good value in prediction for EAD (AUC=0.909

95%

: 0.849~ 0.969) when the cut-off value was 15 258 fg/mg. The best regression equation was Y=-7554+22.64×

-0.169 2×

+0.000345×

(Y: LPC concentration after reperfusion; t: total ischemic time;

: LPC concentration at the moment of donor liver acquisition). The adjusted determination coefficients R

in the modeling set and validation set were 0.944 7 and 0.915 4

respectively

which could well explain the changes of LPC and had a good prediction accuracy for LPC concentration after perfusion.

Conclusion

Our established prediction model well shows the changes of LPC concentration in donor liver tissue

indicates the severity of donor liver damage

and has clinical value in prediction of the occurrence of EAD.

关键词

Keywords

references

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