Clinical value of linked color imaging endoscopy in auxiliary diagnosis of <italic style="font-style: italic">Helicobacter pylori</italic> infection

Liu LIU; Yuxuan LIN; Xiapeng LUO; Yanyi SHEN; He HUANG; Liuping JIA; Chunsheng XIE

doi:10.16016/j.1000-5404.202011187

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Clinical value of linked color imaging endoscopy in auxiliary diagnosis of Helicobacter pylori infection

更新时间：2026-01-09

- Clinical value of linked color imaging endoscopy in auxiliary diagnosis of Helicobacter pylori infection
- Journal of Third Military Medical University Vol. 43, Issue 5, Pages: 446-451(2021)
- 作者机构：
- 作者简介：
- 基金信息：
  
  the Project of National Key R & D Program of China(2018AB001962)
- DOI：10.16016/j.1000-5404.202011187
  CLC：
- Received：08 March 2020，
  
  Published：15 March 2021
- 稿件说明：
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Liu LIU, Yuxuan LIN, Xiapeng LUO, et al. Clinical value of linked color imaging endoscopy in auxiliary diagnosis of Helicobacter pylori infection[J]. Journal of Third Military Medical University, 2021, 43(5): 446-451.
DOI：

Liu LIU, Yuxuan LIN, Xiapeng LUO, et al. Clinical value of linked color imaging endoscopy in auxiliary diagnosis of Helicobacter pylori infection[J]. Journal of Third Military Medical University, 2021, 43(5): 446-451. DOI： 10.16016/j.1000-5404.202011187.

摘要

Abstract

Objective

To investigate the diagnostic value of blue laser linked color imaging (LCI) technology in assistance of detecting infection of

Helicobacter pylori

(Hp).

Methods

A total of 120 patients with positive results of

C-urea breath test (

C-UBT) and 120 individuals with negative results admitted to the Nanhai Hospital due to upper digestive tract symptoms during October 2018 and December 2019 were recruited in the study. Then they were further divided into the study subgroup (undergoing gastroscopy using LCI) and control subgroup (white light imaging

WLI)

respectively

with 60 subjects in each subgroup. Their gender

diagnosis under endoscopy

Hp infection by endoscopic evaluation

result of rapid urease experiment (RUT) and immunohistochemical assay were studied and compared among the groups and subgroups.

Results

There were no significant differences in age

gender and proportions of the diseases diagnosed under endoscopy between the study group and control group (

0.05). The positive rates of Hp infection evaluated by LCI combined with RUT and immunohistochemical assay were significant higher than those from the WLI subgroup (positive group: 93.3%

80.0%

90.0%

75.0%; negative group: 27.9%

13.3%

26.7%

11.7%

0.05). For the positive patients with chronic atrophic gastritis (CAG)

they had significantly higher positive rate of RUT assessed by LCI than by WLI (75.0%

30.8%

0.05). Furthermore

they also had obviously higher positive rates when combined with RUT and immunohistochemical assay than only undergoing simple LCI in positive group and subgroup of chronic non-atr

ophic gastritis (CNAG) (

0.05).

Conclusion

Targeted biopsy guided by LCI for RUT or pathological examination can significantly improve the positive rate of Hp detection

especially to the CAG patients. LCI technology can reduce the risk of gastric neoplasm

and is worthy of promotion in clinical practice.

关键词

Keywords

references

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⁰

Clinical value of linked color imaging endoscopy in auxiliary diagnosis of Helicobacter pylori infection

DOI：10.16016/j.1000-5404.202011187

摘要

Abstract

关键词

Keywords

references