Different surgical methods for gastrointestinal neuroendocrine tumors: comparison on efficacy and prognosis

Xingyu YAO; Wensheng CHEN

doi:10.16016/j.1000-5404.202011029

您当前的位置：

首页 >

文章列表页 >

Different surgical methods for gastrointestinal neuroendocrine tumors: comparison on efficacy and prognosis

更新时间：2026-01-09

- Different surgical methods for gastrointestinal neuroendocrine tumors: comparison on efficacy and prognosis
- Journal of Third Military Medical University Vol. 43, Issue 6, Pages: 522-528(2021)
- 作者机构：
- 作者简介：
- 基金信息：
- DOI：10.16016/j.1000-5404.202011029
  CLC：
- Received：03 November 2020，
  
  Published：30 March 2021
- 稿件说明：
移动端阅览
Xingyu YAO, Wensheng CHEN. Different surgical methods for gastrointestinal neuroendocrine tumors: comparison on efficacy and prognosis[J]. Journal of Third Military Medical University, 2021, 43(6): 522-528.
DOI：

Xingyu YAO, Wensheng CHEN. Different surgical methods for gastrointestinal neuroendocrine tumors: comparison on efficacy and prognosis[J]. Journal of Third Military Medical University, 2021, 43(6): 522-528. DOI： 10.16016/j.1000-5404.202011029.

摘要

Abstract

Objective

To investigate the related risk factors affecting postoperative recurrence and recurrent metastasis in the patients with gastrointestinal neuroendocrine tumors (GI-NETs)

and compare the therapeutic efficacy of different surgical methods as well as their impacts on prognosis.

Methods

The clinical data of 153 GI-NETs patients treated in our hospital from January 2010 to December 2019 were collected and retrospectively analyzed. The clinical characteristics and 5-year recurrence and metastasis rates were analyzed and calculated

and the prognostic factors and survival analysis was subsequently performed. In addition

the therapeutic efficacy was evaluated and compared between the endoscopic surgery and conventional surgery.

Results

Among the 153 GI-NETs patients

90 were males (58.82%) and 63 females (41.18%). According to the 2010 WHO NETs classification

114 cases (74.51%) were in G1 phases

25 (16.34%) in G2 phases and 14 (9.15%) in G3 phases. And 112 patients (73.20%) underwent endoscopic surgery and 41 (26.80%) received conventional surgery. There were 26 cases (16.99%) experiencing recurrence and metastasis within 5 years

with the percentages of 1.31%

3.92%

3.27% and 8.50%

respectively in the duodenum

esophagus

stomach and rectum. The rates of recurrence and metastasis were 3.92% and 13.07% respectively in the endoscopic surgery and conventional surgery. Log-rank test results indicated that there were statistical differences in the recurrence and metastasis of GI-NETs among different ages

tumor sites

tumor sizes

pathological grades

and surgical methods (

0.05). Multivariate Cox regression analysis showed that tumor size

pathological grade

and presence of tumor in the margin were independent risk factors affecting postoperative recurrence and metastasis (

0.05)

and the la

rger the tumor size and the higher the pathological grade

the higher the risks were. No statistical differences were seen in the recurrence and metastasis rates in the patients with G1 or G2 phase GI-NETs less than 2 cm

regardless of the surgery methods they received (

0.05).

Conclusion

Tumor size

pathological grade and presence of tumor in the margin are independent risk factors for postoperative recurrence and metastasis. GI-NETs in G1 and G2 phases less than 2 cm can be resected under endoscopy.

关键词

Keywords

references

YAO J C HASSAN M PHAN A One hundred years after "carcinoid": epidemiology of and prognostic factors for neuroendocrine tumors in 35, 825 cases in the United States J Clin Oncol 2008 26 18 3063 3072 10.1200/JCO.2007.15.4377 YAO J C, HASSAN M, PHAN A, et al . One hundred years after "carcinoid": epidemiology of and prognostic factors for neuroendocrine tumors in 35, 825 cases in the United States[J ] . J Clin Oncol, 2008, 26(18): 3063-3072. DOI: 10.1200/JCO.2007.15.4377.

玄基泽陈丹时畅大连地区神经内分泌肿瘤的流行病学及临床病理分析中国癌症杂志 2014 24 2 146 150 10.3969/j.issn.1007-3969.2014.02.011 玄基泽, 陈丹, 时畅, 等. 大连地区神经内分泌肿瘤的流行病学及临床病理分析[J]. 中国癌症杂志, 2014, 24(2): 146-150.

XUAN J Z CHEN D SHI C Epidemiology and clinico pathological characteristics analysis of 279 neuroendocrine neoplasmscases in Dalian China Oncol 2014 24 2 146 150 10.3969/j.issn.1007-3969.2014.02.011 XUAN J Z, CHEN D, SHI C, et al . Epidemiology and clinico pathological characteristics analysis of 279 neuroendocrine neoplasmscases in Dalian[J ] . China Oncol, 2014, 24(2): 146-150.

KIM H H PARK S J LEE S H Efficacy of endoscopic submucosal resection with a ligation device for removing small rectal carcinoid tumor compared with endoscopic mucosal resection: analysis of 100 cases Dig Endosc 2012 24 3 159 163 10.1111/j.1443-1661.2011.01190.x KIM H H, PARK S J, LEE S H, et al . Efficacy of endoscopic submucosal resection with a ligation device for removing small rectal carcinoid tumor compared with endoscopic mucosal resection: analysis of 100 cases[J ] . Dig Endosc, 2012, 24(3): 159-163. DOI: 10.1111/j.1443-1661.2011.01190.x.

NISHIDA T KAWAI N YAMAGUCHI S Submucosal tumors: comprehensive guide for the diagnosis and therapy of gastrointestinal submucosal tumors Dig Endosc 2013 25 5 479 489 10.1111/den.12149 NISHIDA T, KAWAI N, YAMAGUCHI S, et al . Submucosal tumors: comprehensive guide for the diagnosis and therapy of gastrointestinal submucosal tumors[J ] . Dig Endosc, 2013, 25(5): 479-489. DOI: 10.1111/den.12149.

许学杰消化道神经内分泌癌患者的临床特征及其预后因素分析中国临床研究 2015 28 9 1144 1146, 1150 许学杰. 消化道神经内分泌癌患者的临床特征及其预后因素分析[J]. 中国临床研究, 2015, 28(9): 1144-1146, 1150.

XU X J Clinical characteristics and analysis of prognostic factors in patients with neuroendocrine carcinoma of digestive tract Chin J Clin Res 2015 28 9 1144 1146, 1150 XU X J. Clinical characteristics and analysis of prognostic factors in patients with neuroendocrine carcinoma of digestive tract[J]. Chin J Clin Res, 2015, 28(9): 1144-1146, 1150.

SENTURK H Management of cystic diseases of the pancreas Turk J Gastroenterol 2014 25 1 1 18 10.5152/tjg.2014.0001 SENTURK H. Management of cystic diseases of the pancreas[J]. Turk J Gastroenterol, 2014, 25(1): 1-18. DOI: 10.5152/tjg.2014.0001.

ZIARI K ALIZADEH K RAHMANI O Primary lymphoma of appendix: report of three cases and review of literature Iranian J Pathol 2014 9 2 160 168 http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=97718653&site=ehost-live ZIARI, K, ALIZADEH K, RAHMANI O, et al . Primary lymphoma of appendix: report of three cases and review of literature[J ] . Iranian J Pathol, 2014, 9(2): 160-168.

LOBO-MACHÍN I DELGADO-PLASENCIA L HERNÁNDEZ- GONZÁLEZ I Appendiceal diverticulitis and acute appendicitis: differences and similarities Rev Esp Enferm Dig 2014 106 7 452 458 http://www.ncbi.nlm.nih.gov/pubmed/25490164 LOBO-MACHÍN I, DELGADO-PLASENCIA L, HERNÁNDEZ- GONZÁLEZ I, et al . Appendiceal diverticulitis and acute appendicitis: differences and similarities[J ] . Rev Esp Enferm Dig, 2014, 106(7): 452-458.

任海芬张晓昉贺菊香原发于直肠、肺的神经内分泌肿瘤的临床病理特征对患者生存率的影响广西医学 2017 39 6 764 767 https://www.cnki.com.cn/Article/CJFDTOTAL-GYYX201706003.htm 任海芬, 张晓昉, 贺菊香. 原发于直肠、肺的神经内分泌肿瘤的临床病理特征对患者生存率的影响[J]. 广西医学, 2017, 39(6): 764-767.

REN H F ZHANG X F HE J X Effect of clinicopathological features on survival rate in patients with primary rectal/pulmonary neuroendocrine tumors Guangxi Med J 2017 39 6 764 767 https://www.cnki.com.cn/Article/CJFDTOTAL-GYYX201706003.htm REN H F, ZHANG X F, HE J X. Effect of clinicopathological features on survival rate in patients with primary rectal/pulmonary neuroendocrine tumors[J]. Guangxi Med J, 2017, 39(6): 764-767.

宇永军张诗武李玉玮 265例神经内分泌肿瘤的临床病理特征及预后分析天津医药 2018 46 1 65 69 https://www.cnki.com.cn/Article/CJFDTOTAL-TJYZ201801015.htm 宇永军, 张诗武, 李玉玮, 等. 265例神经内分泌肿瘤的临床病理特征及预后分析[J]. 天津医药, 2018, 46(1): 65-69.

YU Y J ZHANG S W LI Y W Clinicopathological characteristics and prognostic analysis of 265 cases of neuroendocrine tumors Tianjin Med J 2018 46 1 65 69 https://www.cnki.com.cn/Article/CJFDTOTAL-TJYZ201801015.htm YU Y J, ZHANG S W, LI Y W, et al . Clinicopathological characteristics and prognostic analysis of 265 cases of neuroendocrine tumors[J ] . Tianjin Med J, 2018, 46(1): 65-69.

徐建明杨晨胃肠胰腺神经内分泌肿瘤国际诊断共识的解读临床肿瘤学杂志 2011 16 11 1033 1038 10.3969/j.issn.1009-0460.2011.11.018 徐建明, 杨晨. 胃肠胰腺神经内分泌肿瘤国际诊断共识的解读[J]. 临床肿瘤学杂志, 2011, 16(11): 1033-1038.

XU J M YANG C Interpretation consensus on diagnosis of gastroenteropancreatic neuroendocrine neoplasm Chin Clin Oncol 2011 16 11 1033 1038 10.3969/j.issn.1009-0460.2011.11.018 XU J M, YANG C. Interpretation consensus on diagnosis of gastroenteropancreatic neuroendocrine neoplasm[J]. Chin Clin Oncol, 2011, 16(11): 1033-1038.

李增山胃肠胰神经内分泌肿瘤分类及病理学进展浙江大学学报(医学版) 2016 45 1 10 23 10.3785/j.issn.1008-9292.2016.01.03 李增山. 胃肠胰神经内分泌肿瘤分类及病理学进展[J]. 浙江大学学报(医学版), 2016, 45(1): 10-23.

LI Z S Classification and clinicopathological characteristics of gastroenteropancreatic neuroendocrine neoplasms J Zhejiang Univ (Med Sci) 2016 45 1 10 23 10.3785/j.issn.1008-9292.2016.01.03 LI Z S. Classification and clinicopathological characteristics of gastroenteropancreatic neuroendocrine neoplasms[J]. J Zhejiang Univ (Med Sci), 2016, 45(1): 10-23.

邓会岩刘月平王心然 467例胃肠道神经内分泌肿瘤的临床病理特征及淋巴结转移危险因素分析中华消化外科杂志 2017 3 287 292 10.3760/cma.j.issn.1673-9752.2017.03.013 邓会岩, 刘月平, 王心然, 等. 467例胃肠道神经内分泌肿瘤的临床病理特征及淋巴结转移危险因素分析[J]. 中华消化外科杂志, 2017(3): 287-292.

DENG H Y LIU Y P WANG X R Clinicopathological features and risk factors of lymph node metastasis of gastrointestinal neuroendocrine neoplasms in 467 patients Chin J Dig Surg 2017 3 287 292 10.3760/cma.j.issn.1673-9752.2017.03.013 DENG H Y, LIU Y P, WANG X R, et al . Clinicopathological features and risk factors of lymph node metastasis of gastrointestinal neuroendocrine neoplasms in 467 patients[J ] . Chin J Dig Surg, 2017(3): 287-292.

GAUJOUX S SAUVANET A BELGHITI J Place of surgical resection in the treatment strategy of gastrointestinal neuroendocrine tumors Target Oncol 2012 7 3 153 159 10.1007/s11523-012-0230-0 GAUJOUX S, SAUVANET A, BELGHITI J. Place of surgical resection in the treatment strategy of gastrointestinal neuroendocrine tumors[J]. Target Oncol, 2012, 7(3): 153-159. DOI: 10.1007/s11523-012-0230-0.

童安莉李汉忠多发内分泌肿瘤治疗共识与争议协和医学杂志 2020 11 4 365 369 https://www.cnki.com.cn/Article/CJFDTOTAL-XHYX202004002.htm 童安莉, 李汉忠. 多发内分泌肿瘤治疗共识与争议[J]. 协和医学杂志, 2020, 11(4): 365-369.

TONG A L LI H Z Consensus and controversy on the treatment of multiple endocrine neoplasia Med J PUMCH 2020 11 4 365 369 https://www.cnki.com.cn/Article/CJFDTOTAL-XHYX202004002.htm TONG A L, LI H Z. Consensus and controversy on the treatment of multiple endocrine neoplasia[J]. Med J PUMCH, 2020, 11(4): 365-369.

邵成浩彭俊峰胰腺神经内分泌肿瘤肝转移的外科治疗协和医学杂志 2020 11 4 383 388 邵成浩, 彭俊峰. 胰腺神经内分泌肿瘤肝转移的外科治疗[J]. 协和医学杂志, 2020, 11(4): 383-388.

SHAO C H PENG J F Surgical treatment of pancreatic neuroendocrine neoplasm with liver metastasis Med J PUMCH 2020 11 4 383 388 SHAO C H, PENG J F. Surgical treatment of pancreatic neuroendocrine neoplasm with liver metastasis[J]. Med J PUMCH, 2020, 11(4): 383-388.

徐建明梁后杰秦叔逵中国胃肠胰神经内分泌肿瘤专家共识(2016年版) 临床肿瘤学杂志 2016 21 10 927 946 https://www.cnki.com.cn/Article/CJFDTOTAL-LCZL201610013.htm 徐建明, 梁后杰, 秦叔逵, 等. 中国胃肠胰神经内分泌肿瘤专家共识(2016年版)[J]. 临床肿瘤学杂志, 2016, 21(10): 927-946.

XU J M LIANG H J QIN S K Expert consensus on gastrointestinal pancreatic neuroendocrine tumors in China (2016 edition) Chin Clin Oncol 2016 21 10 927 946 https://www.cnki.com.cn/Article/CJFDTOTAL-LCZL201610013.htm XU J M, LIANG H J, QIN S K. Expert consensus on gastrointestinal pancreatic neuroendocrine tumors in China (2016 edition)[J]. Chin Clin Oncol, 2016, 21(10): 927-946.

Views

下载量

CSCD

Alert me when the article has been cited

提交

Tools

Publicity Resources

Impact of molecular heterogeneity of NPM1 mutations on prognosis of acute myeloid leukemia: a clinical report of 86 cases

Total colonic aganglionosis in children: clinical manifestations, diagnosis, treatment and outcome

Relevant factors for predicting 30-day mortality in intracerebral hemorrhage and clinical application of the new grading scale

A novel estrogen receptor expression stratification (low/moderate/high) based on Chinese population provides more accurate prognosis prediction for HR⁺/HER2^- early breast cancer patients

Related Author

YU Xiaoda

GUO Jiangang

WANG An’an

LI Jiajing

LIU Bei

章镇宇

孙静

侯金平

Related Institution

the First Clinical Medical College of Lanzhou University, the First Hospital of Lanzhou University

Department of Hematology, the First Hospital of Lanzhou University

The First Clinical Medical College， Lanzhou University

Department of Hematology， the Second Hospital & Clinical Medical School， Lanzhou University

Department of Hematology， Gansu Provincial Hospital

⁰