Polymorphism of DNA repair gene APE1 (Asp148Glu) is associated with risk and prognosis of cervical cancer in women of Southwest China

Wenjing XU; Shiheng ZHANG; Dong WANG

doi:10.16016/j.1000-5404.202010128

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Polymorphism of DNA repair gene APE1 (Asp148Glu) is associated with risk and prognosis of cervical cancer in women of Southwest China

更新时间：2026-01-09

- Polymorphism of DNA repair gene APE1 (Asp148Glu) is associated with risk and prognosis of cervical cancer in women of Southwest China
- Journal of Third Military Medical University Vol. 43, Issue 5, Pages: 418-424(2021)
- 作者机构：
- 作者简介：
- 基金信息：
  
  the General Program of National Natural Science Foundation of China(30670628);the General Program of National Natural Science Foundation of China(30801367)
- DOI：10.16016/j.1000-5404.202010128
  CLC：
- Received：20 October 2020，
  
  Published：15 March 2021
- 稿件说明：
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Wenjing XU, Shiheng ZHANG, Dong WANG. Polymorphism of DNA repair gene APE1 (Asp148Glu) is associated with risk and prognosis of cervical cancer in women of Southwest China[J]. Journal of Third Military Medical University, 2021, 43(5): 418-424.
DOI：

Wenjing XU, Shiheng ZHANG, Dong WANG. Polymorphism of DNA repair gene APE1 (Asp148Glu) is associated with risk and prognosis of cervical cancer in women of Southwest China[J]. Journal of Third Military Medical University, 2021, 43(5): 418-424. DOI： 10.16016/j.1000-5404.202010128.

摘要

Abstract

Objective

To investigate whether the polymorphism of the DNA repair gene APE1(Asp148Glu) is associated with the risk and prognosis of cervical cancer in women of Southwest China.

Methods

We studied the clinical features of 290 woman with cervical cancer diagnosed in Daping hospital from January 2007 to July 2014. And another 290 healthy volunteers who took physical examination during the same period were recruited and served as normal control. The patients were followed up for the total survival. PCR-CTPP was used detect the genotype of APE1(Asp148Glu and -141T/G) in the patients and normal control.

Chi

-square test was applied to assess the distribution of individual clinical characteristics

and Hardy-Weinberg equilibrium was used to analyze the polymorphisms of these genes between the case and control. Multivariate logistic regression models were to assess the association of these polymorphisms with risk of cervical cancer. And Kaplan-Meier survival analysis was used to evaluate the relationship of overall survivals(OS) in different genotypes.

Results

The Glu/Glu genotype showed a lower risk of cervi

cal cancer(

=0.542

0.05) when compared with the APE1 Asp148 Asp/Asp genotype

especially for the individuals with following features: childbirth

=0.345

0.05)

menarche older than 14 years old(

=0.522

0.05)

non-menopause(

=0.324

0.05)

age of menopause ≥45 years old(

=0.495

0.05) or squamous carcinoma(

=0.597

0.05). And those carrying Glu genotype had a higher OS benefit than those carrying the APE1 Asp148 Asp genotypes(

=0.001). However

there was no significant association between the APE1 pro-141T/G polymorphism and risk of cervical cancer.

Conclusion

Homozygous APE1 148 Glu/ Glu genotype has a reduced risk and a better prognosis of cervical cancer.

关键词

Keywords

references

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