Influence of diffuse oxygen supply on physiological effects in migrants in plateau: a study based on a new accommodation cabin

Zhuang RAN; Yu CHEN; Chao TAN; Xinyuan LIU; Weishuai WANG; Xuchuan SUN; Yongjun LUO

doi:10.16016/j.1000-5404.202010080

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Influence of diffuse oxygen supply on physiological effects in migrants in plateau: a study based on a new accommodation cabin

Clinical Medicine | 更新时间：2026-01-09

- Influence of diffuse oxygen supply on physiological effects in migrants in plateau: a study based on a new accommodation cabin
- Journal of Third Military Medical University Vol. 43, Issue 8, Pages: 707-714(2021)
- 作者机构：
  
  400038 重庆，陆军军医大学(第三军医大学)陆军卫勤训练基地军事医学地理学教研室
- 作者简介：
- 基金信息：
  
  the National Key Research and Development Project of China(2017YFC0806300);the Special Program for Improving Scientific and Technological Innovation Ability of Army Medical University(2019XYY09);the Special Project of Second Comprehensive Scientific Investigation and Research on Qinghai-Tibet Plateau From Ministry of Science and Technology(2019QZKK0607)
- DOI：10.16016/j.1000-5404.202010080
  CLC： R339.54;R459.6;R852.14
- Received：15 October 2020，
  
  Revised：2021-02-08，
  
  Published：30 April 2021
- 稿件说明：
移动端阅览
Zhuang RAN, Yu CHEN, Chao TAN, et al. Influence of diffuse oxygen supply on physiological effects in migrants in plateau: a study based on a new accommodation cabin[J]. Journal of Third Military Medical University, 2021, 43(8): 707-714.
DOI：

Zhuang RAN, Yu CHEN, Chao TAN, et al. Influence of diffuse oxygen supply on physiological effects in migrants in plateau: a study based on a new accommodation cabin[J]. Journal of Third Military Medical University, 2021, 43(8): 707-714. DOI： 10.16016/j.1000-5404.202010080.

摘要

目的

研究弥散吸氧对移居高原人员缺氧应激、血氧饱和度以及人体代谢过程的影响，阐明新型供氧方式的抗缺氧作用及其可能的分子机制。

方法

以移居海拔3 540 m高原某地1年以上的10名高原人员为研究对象，以新研发的弥散供氧住宿方舱为实验场所，研究对象在住宿方舱内连续弥散吸氧3 d，2 h/d。采用自身对照研究方法，检测研究对象吸氧前后生理指标、血常规指标及血浆代谢谱的变化。

结果

① 研究对象在住宿方舱内弥散吸氧期间，第1天舱内氧浓度为(22.85±0.36)%、第2天为(22.52±0.76)%、第3天为(22.57±1.05)%。②研究对象吸氧后血氧饱和度显著提高、脉率明显下降(

0.01)；血压吸氧前后比较差异无统计学意义。③研究对象吸氧后共有44种代谢物发生了显著改变(VIP＞1，

0.05)。其中，正离子模式下鉴定出18种，负离子模式下鉴定出26种。发现主要有4条代谢通路发生了明显变化[impact＞0.05，-log

(

)＞1.3

]

。

结论

通过弥散供氧方式吸氧能显著提高机体的心肺供氧能力，有效缓解高原缺氧寒冷环境对人体代谢的影响。

Abstract

Objective

To determine the effects of diffuse oxygen inhalation on hypoxia stress

blood oxygen saturation and human metabolic process in migrants in plateau

and to illustrate the anti-hypoxia effect of a new oxygen supply mode and its possible molecular mechanism.

Methods

Ten workers who had migrated to a plateau at an altitude of 3 540 m for more than 1 year were recruited as the subjects. They were asked to breathe oxygen in a newly developed accommodation cabin with diffuse oxygen supply for 3 consecutive days

2 h per day. Their physiological indexes

blood routine indexes and plasma metabolic profiles before and after oxygen intake were measured and compared.

Results

① The oxygen concentration was (22.85±0.36)% on the first day

(22.52±0.76)% on the second day and (22.57±1.05)% on the third day during the diffusion oxygen inhalation in the accommodation cabin. ②The oxygen saturation level and pulse rate were significantly increased after oxygen inhalation in the subjects (

0.01)

but there was no significant change in blood pressure (

0.05). ③ There were 44 metabolites significantly changed (VIP

0.05). Among them

18 metabolites were identified in the positive ion mode and 27 in the negative ion mode. And 4 major metabolic pathways also had significant changes [impact

0.05

-log

(

)

1.3

]

Conclusion

Oxygen inhalation

via

diffuse oxygen supply can effectively improve the capacity of cardiopulmonary oxygen supply

and alleviate the impact of hypoxia and cold environment on human metabolism.

关键词

Keywords

references

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