Correlation between rs3740051 polymorphism of SIRT1 gene and volume of brain gray matter in depression patients

Shanshan GU; Daiyan LIU; Ling JI

doi:10.16016/j.1000-5404.202008022

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Correlation between rs3740051 polymorphism of SIRT1 gene and volume of brain gray matter in depression patients

Neurosciences | 更新时间：2026-01-09

- Correlation between rs3740051 polymorphism of SIRT1 gene and volume of brain gray matter in depression patients
- Journal of Third Military Medical University Vol. 43, Issue 2, Pages: 137-145(2021)
- 作者机构：
  
  400038 重庆，陆军军医大学(第三军医大学)第一附属医院医学心理科
- 作者简介：
- 基金信息：
- DOI：10.16016/j.1000-5404.202008022
  CLC： R322.81;R394.3;R749.4
- Received：04 August 2020，
  
  Revised：2020-09-21，
  
  Published：30 January 2021
- 稿件说明：
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Shanshan GU, Daiyan LIU, Ling JI. Correlation between rs3740051 polymorphism of SIRT1 gene and volume of brain gray matter in depression patients[J]. Journal of Third Military Medical University, 2021, 43(2): 137-145.
DOI：

Shanshan GU, Daiyan LIU, Ling JI. Correlation between rs3740051 polymorphism of SIRT1 gene and volume of brain gray matter in depression patients[J]. Journal of Third Military Medical University, 2021, 43(2): 137-145. DOI： 10.16016/j.1000-5404.202008022.

摘要

目的

研究首发未治疗抑郁症患者SIRT1基因rs3740051基因多态性与脑灰质结构之间的关系。

方法

选取2018年3月至2019年9月陆军军医大学第一附属医院医学心理科门诊抑郁症患者75例，招募健康对照43例，使用磁共振采集高分辨率结构像数据，并对SIRT1基因rs340051位点进行基因分型测序

根据分型结果将抑郁症患者组和健康对照组进一步分为4组:抑郁(AA)组、抑郁(AG/GG)组、对照(AA)组和对照(AG/GG)组，分析SIRT1基因rs3740051位点基因型(AA和AG/GG)与疾病诊断(抑郁和对照)对于大脑灰质体积交互效应和各自主效应。

结果

① 4组大脑灰质体积存在诊断和基因型交互效应，在左侧海马旁回和左侧顶下缘角回，抑郁(AG/GG)组灰质体积大于抑郁(AA)组(

0.05)，对照(AA)组灰质体积大于对照(AG/GG)组(

0.05)。②4组大脑灰质体积存在诊断主效应，在左侧顶下缘角回，对照(AA)组与抑郁(AA)组差异无统计学意义，抑郁(AG/GG)组灰质体积大于对照(AG/GG)组(

0.05)

在右侧楔前叶，抑郁(AG/GG)组灰质体积大于对照组(AG/GG)(

0.05)，抑郁(AA)组灰质体积大于对照(AA)组(

0.05)。③4组大脑灰质体积存在基因型主效应，在右侧内侧额上回和左侧补充运动区区域，对照(AG/GG)组灰质体积大于对照(AA)组(

0.05)，抑郁(AG/GG)组灰质体积大于抑郁(AA)组(

0.05)。

结论

SIRT1基因rs3740051位点基因多态性位点可能与抑郁症患者大脑灰质体积的改变有关，携带G等位基因(AG/GG)相对于不携带G等位基因(AA)对于抑郁症大脑灰质体积改变更大，该改变可能在抑郁症发病机制中发挥作用。

Abstract

Objective

To investigate the correlation between the polymorphism of SIRT1 locus rs3740051 and the structure of brain gray matter in patients with first-onset untreated depression as well as in healthy controls.

Methods

Clinical data of 75 patients (15 males and 60 females) with first-onset depression treated in our hospital from March 2018 to September 2019 were recruited

and another 43 volunteers were enrolled as healthy controls. Their brain structural data were collected from high resolution images after magnetic resonance imaging

and the allelic and genotypic frequencies of rs3740051 polymorphisms of SIRT1 gene were determined with DNA sequencing in the 2 groups. Based on the detected genotypes

the depression patients and healthy controls were classified into 4 groups: depression (AA)

depression (AG/GG)

control (AA) and control (AG/GG) groups. The interaction effects of SIRT1 rs3740051 genotypes (AA or AG/GG) and disease diagnosis (depression or control)

as well as their respective main effects on brain gray matter

on brain gray matter volume were analyzed.

Results

① Diagnostic and genotype interaction effects on the gray matter volume were shown in all the 4 groups. In the left parahippocampal gyrus and left inferior parietal marginal angular gyrus

the gray matter volume was larger in the depression (AG/GG) group than depression (AA) group (

0.05)

and larger in the control (AA) group than control (AG/GG) group (

0.05). ②Diagnostic main effects on the gray matter volume existed in all the 4 groups. In the left inferior parietal marginal angular gyrus

the gray matter volume of the depression (AG/GG) group was greater than that of control (AG/GG) group (

0.05)

though the depression (AA) group and control (AA) group showed no significant difference (

0.05). At the right precuneus

the gray matter volume was larger in both depression (AG/GG) and depression (AA) groups as compared with the corresponding control groups (

0.05). ③Genotype main effects were also found on gray matter volume of the 4 groups. In the right medial superior frontal gyrus and left supplementary motor area

the gray matter volume was larger in both depression (AG/GG) and control (AG/GG) groups than the corresponding (AA) genotype groups (

0.05).

Conclusion

The polymorphism of SIRT1 rs3740051 may be related to the alteration of brain gray matter volume in patients with depression. Patients carrying G allele (AG/GG) have more changes in gray matter volume than those not carrying (AA)

and these changes may play a role in the pathogenesis of depression.

关键词

Keywords

references

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