Reduction of T cell subpopulations peripheral blood is a predictor of renal endpoint events in patients with chronic kidney disease
- Journal of Third Military Medical University Vol. 43, Issue 5, Pages: 438-445(2021)
- 作者机构：
- 作者简介：
- 基金信息：the Clinical Medical Talent Training Program of Army Medical University(2018XLC1007)
DOI：10.16016/j.1000-5404.202008018
CLC：Received：03 August 2020，
Published：15 March 2021
- 稿件说明：
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Yu QIAO, Jiachuan XIONG, Jinghong ZHAO. Reduction of T cell subpopulations peripheral blood is a predictor of renal endpoint events in patients with chronic kidney disease[J]. Journal of Third Military Medical University, 2021, 43(5): 438-445.
Yu QIAO, Jiachuan XIONG, Jinghong ZHAO. Reduction of T cell subpopulations peripheral blood is a predictor of renal endpoint events in patients with chronic kidney disease[J]. Journal of Third Military Medical University, 2021, 43(5): 438-445. DOI： 10.16016/j.1000-5404.202008018.
摘要
Abstract
Objective
2
To investigate the correlation between the counts of CD3
+
CD4
+
and CD8
+
T cells in peripheral blood as well as the ratio of CD4
+
/CD8
+
T cells and the renal endpoint events (renal substitutive therapy) in patients with chronic kidney disease (CKD)
and to determine whether these T cell parameters are prognostic indicators for pre-dialysis CKD patients.
Methods
2
A total of 568 pre-dialysis patients with primary CKD at stage 3~5 admitted in our hospital from March 2015 to January 2019 were enrolled and followed up in this study. Immunofluorescence flow cytometry was adopted to detect the counts of CD3
+
CD4
+
and CD8
+
T cells
and the ratio of CD4
+
/CD8
+
T cells was calculated. The CKD patients then were divided into normal- and low-level groups of CD3
+
CD4
+
and CD8
+
T cell counts
according to the clinical reference values. The renal endpoint event was defined as initiation of a renal substitutive therapy duo to irreversible deterioration of kidney function
including peritoneal dialysis
hemodialysis
and kidney transplantation. Kaplan-Meier analysis was used to compare the survival time betw
een the 2 groups. Cox regression model was adopted to analyze the risk factors associated with CKD progression.
Results
2
There were eventually 240 patients (42.25%) receiving renal substitutive therapy during a mean follow-up of 2.25 years. Kaplan-Meier analysis showed that lower counts of CD3
+
CD4
+
and CD8
+
T cells were independently associated with higher occurrence of the renal endpoint events. Cox regression model suggested that the low-level groups of the above 3 kinds of T cells had significantly higher risks in progression into the endpoint events (
HR
=1.575
1.511
1.583). After multivariable adjustment
the risk of the endpoint events remained increased in patients from the low-level group (
HR
=1.803
1.945
2.010).
Conclusion
2
The reduction of CD3
+
CD4
+
and CD8
+
T cells in peripheral blood is closely related to the occurrence of renal substitutive therapy
which might be used as a predictive factor of renal outcome for CKD patients at pre-dialysis stage 3~5.
关键词
Keywords
references
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