Features of early injuries in canine model of high dose depleted uranium exposure through bronchial spraying

Weilin FU; Xiangyu CHEN; Rong LI; Yong ZHU; Zhu TIAN; Feng ZENG; Yao XIAO; Minghua LIU

doi:10.16016/j.1000-5404.202007210

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Features of early injuries in canine model of high dose depleted uranium exposure through bronchial spraying

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- Features of early injuries in canine model of high dose depleted uranium exposure through bronchial spraying
- Journal of Third Military Medical University Vol. 43, Issue 1, Pages: 52-58(2021)
- 作者机构：
- 作者简介：
- 基金信息：
  
  the Key Project of Military Logistic Scientific Research(BWS15J009);the Key Project of Military Logistics Scientific Research(BLJ20J005)
- DOI：10.16016/j.1000-5404.202007210
  CLC：
- Received：27 July 2020，
  
  Published：15 January 2021
- 稿件说明：
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Weilin FU, Xiangyu CHEN, Rong LI, et al. Features of early injuries in canine model of high dose depleted uranium exposure through bronchial spraying[J]. Journal of Third Military Medical University, 2021, 43(1): 52-58.
DOI：

Weilin FU, Xiangyu CHEN, Rong LI, et al. Features of early injuries in canine model of high dose depleted uranium exposure through bronchial spraying[J]. Journal of Third Military Medical University, 2021, 43(1): 52-58. DOI： 10.16016/j.1000-5404.202007210.

摘要

Abstract

Objective

To explore the features of early damages due to high dose depleted uranium (DU) exposure through bronchial spraying.

Methods

A canine model of acute lung injury was established by bronchial spraying of 20 mg/kg DU suspension. Serum uranium content

arterial blood gas

blood routine

liver function

kidney function

myocardial enzymes

cytokines

and CT examination were tested or performed at pre-exposure

and 3 and 8 h and 1

5 and 7 d after exposure.

Results

The serum uranium content was significantly increased at all the time points after exposure than the content before exposure (

0.05). And the content at 8 h and 1

5 and 7 d was notably higher than the content at 3 h (

0.01)

and that at 8 h and 7 d was obviously higher than it at 1

3 and 5 d (

0.05). Compared with the values before exposure

the counts of leukocytes and neutrophils were risen at 8 h and 5 d after exposure (

0.05)

the levels of creatine kinase (CK)

creatine kinase-MB (CK-MB) and aspartate aminotransferase (AST) were increased sharply at 3 h (

0.05)

the creatinine level was dramatically elevated at 5 and 7 d (

0.01)

and the level of IL-8 was raised at 3 and 5 d after DU exposure (

0.05). The CT scanning results showed that the scores of pulmonary shadows were higher at all time points after than before exposure

and there were significant differences in the score at 3 and 8 h when compared with oth

er time points (

0.01). The score at 1 d was much higher than that at 5 and 7 d (

0.05).

Conclusion

The distributing rate of high dose DU exposure through bronchial spraying is possibly in line with two-compartment model. Severe inflammation occurs in the lungs at the 8th hour after exposure. Renal function is obviously impaired at day 5

along with another rise of serum uranium content.

关键词

Keywords

references

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