Clinical characteristics of EVI1+ AML and clinical observation of hematopoietic stem cell transplantation on these patients
- Journal of Third Military Medical University Vol. 42, Issue 17, Pages: 1699-1705(2020)
- 作者机构：
- 作者简介：
- 基金信息：Supported by the Special Project for Clinical Medical Research Talents of Science and Technology Innovation Capacity Promotion Plan of Army Medical University(2019XLC3034)
DOI：10.16016/j.1000-5404.202006024
CLC：Received：02 June 2020，
Published：15 September 2020
- 稿件说明：
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Shijia LIN, Yuqing LIU, Han YAO, et al. Clinical characteristics of EVI1+ AML and clinical observation of hematopoietic stem cell transplantation on these patients[J]. Journal of Third Military Medical University, 2020, 42(17): 1699-1705.
Shijia LIN, Yuqing LIU, Han YAO, et al. Clinical characteristics of EVI1+ AML and clinical observation of hematopoietic stem cell transplantation on these patients[J]. Journal of Third Military Medical University, 2020, 42(17): 1699-1705. DOI： 10.16016/j.1000-5404.202006024.
摘要
Abstract
Objective
2
To investigate the clinical characteristics
treatment response
and prognosis of acute myeloid leukemia (AML) with high expression of EVI1 and the effectiveness of hematopoietic stem cell transplantation (HSCT).
Methods
2
A total of 7 subjects diagnosed with EVI1
+
AML in our center from January 2016 to May 2020 were enrolled in this study. They were 1 male and 6 females
and at a median age of 8 (3～49) years. The expression level of EVI1 gene was measured by nested PCR
analyzed together with morphological type
cytogenetics and molecular biology data of bone marrow. To characterize the clinical features of EVI1
+
AML and to observe the therapeutic effect of hematopoietic stem cell transplantation.
Results
2
The results of risk stratification showed that all these EVI1
+
AML patients were at high risk. By the end of follow-up on May 31
2020
2 patients relapsed during standard chemotherapy. For the 6 patients undergoing allogeneic HSCT (allo-HSCT)
5 achieved complete remission (CR) before transplantation
and the other 1 only achieved secondary CR after salvage transplantation. One patient relapsed during standard chemotherapy
did not receive transplantation
and died 10 months after diagnosis. All 6 patients who received allo-HSCT stayed in remission by the end of the study.
Conclusion
2
EVI1
+
AML patients have poor outcomes
and are at high risk of relapse
but achieve sound CR
with M4 and M5 more commonly. Allo-HSCT can significantly improve the prognosis of EVI1
+
AML patients.
关键词
Keywords
references
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