Related factors of perianal tissue infection in patients with malignant hematopathy: a meta-analysis
- Journal of Third Military Medical University Vol. 42, Issue 17, Pages: 1763-1770(2020)
- 作者机构：
- 作者简介：
- 基金信息：Clinical Research Project and Talent Training Plan of Army Medical University(2018XLC3053);Clinical Research Project and Talent Training Plan of Army Medical University(2019XLC3014);the General Program of Natural Science Foundation of Chongqing(CSTC2019jcyjmsxmX0273);the Special Project of Science and Technology Innovation for Social Undertakings and Livelihood Guarantee of Chongqing(CSTC2016shms-ztzx10003)
DOI：10.16016/j.1000-5404.202005137
CLC：Received：18 May 2020，
Published：15 September 2020
- 稿件说明：
移动端阅览
Xiaoli CHEN, Yimei FENG, Hengrui SUN, et al. Related factors of perianal tissue infection in patients with malignant hematopathy: a meta-analysis[J]. Journal of Third Military Medical University, 2020, 42(17): 1763-1770.
Xiaoli CHEN, Yimei FENG, Hengrui SUN, et al. Related factors of perianal tissue infection in patients with malignant hematopathy: a meta-analysis[J]. Journal of Third Military Medical University, 2020, 42(17): 1763-1770. DOI： 10.16016/j.1000-5404.202005137.
摘要
Abstract
Objective
2
To analyze the risk factors of perianal infection in patients with malignant hematopathy in order to provide theoretical basis for the prevention.
Methods
2
Case-control studies and cohort studies concerning the related factors or the main risk factors for perianal tissue infection in patients with malignant hematopathy were retrieved from the indexed articles from PubMed
Cochrane Library
Web of Science
China National Knowledge Infrastructure Database (CNKI)
China Science and Technology Periodical Database (VIP)
and Wanfan Database. Two evaluators independently retrieved and screened the literature
extracted the data
and made methodological quality assessment of the included literatures a
nd cross-checked. Controversial issues were discussed and agreed by 3 evaluators together. Software Revman 5.3 was used for meta-analysis. A fixed-effect model or a random-effect model was used to combine odds ratio (
OR
) values and 95% confidence intervals (
CI
) to analyze each relevant risk factor
and sensitivity analysis was employed to assess the stability of the results.
Results
2
Eight literatures
containing a total of 1 857 cases were included for further analysis
including 272 cases (272/1 857
14.6%) in the perianal infection group and 1 585 cases in the control group. The results of meta-analysis showed that age older than 50 years
irremission after chemotherapy
and the absolute count of neutrophils
<
0.5×10
9
/L
and acute myeloid leukemia were related to the formation of perianal infection in patients with hematopathy. There were no statistical difference in the incidence of perianal infection between male and female patients (
P
>
0.05).
Conclusion
2
The risk factors for perianal infection in patients with malignant hematologic disease are those aged over 50 years
unrelieved chemotherapy
and absolute value of neutrophils
<
0.5×10
9
/L and acute myeloid leukemia.
关键词
Keywords
references
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