Two-year outcome of Fs-LASIK combined accelerated corneal cross-linking for moderate and high myopia

Hong JI; Jie XIONG; Chenxing ZHANG; Qihui LUO; Ke WANG; Qingqing ZHOU; Youhui ZHOU

doi:10.16016/j.1000-5404.202005022

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Two-year outcome of Fs-LASIK combined accelerated corneal cross-linking for moderate and high myopia

更新时间：2026-01-09

- Two-year outcome of Fs-LASIK combined accelerated corneal cross-linking for moderate and high myopia
- Journal of Third Military Medical University Vol. 42, Issue 19, Pages: 1957-1964(2020)
- 作者机构：
- 作者简介：
- 基金信息：
- DOI：10.16016/j.1000-5404.202005022
  CLC：
- Received：06 May 2020，
  
  Published：15 October 2020
- 稿件说明：
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Hong JI, Jie XIONG, Chenxing ZHANG, et al. Two-year outcome of Fs-LASIK combined accelerated corneal cross-linking for moderate and high myopia[J]. Journal of Third Military Medical University, 2020, 42(19): 1957-1964.
DOI：

Hong JI, Jie XIONG, Chenxing ZHANG, et al. Two-year outcome of Fs-LASIK combined accelerated corneal cross-linking for moderate and high myopia[J]. Journal of Third Military Medical University, 2020, 42(19): 1957-1964. DOI： 10.16016/j.1000-5404.202005022.

摘要

Abstract

Objective

To evaluate the safety

effectiveness and predictability of femtosecond laser assisted excimer laser

in-situ

keratomileusis combined with accelerated cross-linking (F

s-LASIK Xtra) in moderate and high myopia with thin cornea.

Methods

A retrospective case-control study was carried out after the whole clinical data of 2 years' follow-up from the patients undergoing Fs-LASIK Xtra or single Fs-LASIK in our hospital during March 2016 and March 2017 were collected. Forty-four patients (88 eyes) undergoing Fs-LASIK Xtra surgeries were included in the study group

and 50 patients (100 eyes) Fs-LASIK surgeries in the control group. Changes in uncorrected distance visual acuity (UCVA)

correction of best distant vision (BCVA)

equivalent spherical mirror (SEQ)

corneal curvature

intraocular pressure

endothelium

depth of demarcation line in anterior segmental optical coherence tomography (OCT)

and the incidences of postoperative complications

such as interlaminar inflammation reaction and corneal haze in 1 week

and 1

12 and 24 months after surgery were measured and observed.

Results

The pre-operative BCVA and post-operative UCVA at 3

12 and 24 months were all significant improved (

0.05). The pre-operative corneal curvature and SEQ were also greatly decreased in 3

12 and 24 months after surgery. The SEQ reached the predicted value in both groups in 24 months

but there was no obvious difference between them (

0.05). The distribution of positive SEQ was notably higher

while that of negative SEQ was lower in the study group when compared to the control group (

0.05). Significant differences in the percentages of regression and overcorrection at 24 months were seen between the 2 groups (

0.05)

with the study group having higher percentage of overcorrection

but lower the percentage of regression than the control group. In the study group

the depth of demarcation line of 32 eyes was 224.57±62.01 μm. Six eyes (6.8%) with grade 0.5 haze and 2 eyes (2.3%) with grade 1 haze occurred in 1 to 3 months after surgery

the symptoms wer

e disappeared after topical steroid treatment which had no negative influence in the final visual acuity.

Conclusion

Fs-LASIK Xtra can treat moderate and high myopia with thin cornea with good safety

effectiveness and predictability. Sufficient glucocorticosteroid eye drop should be used regularly to prevent post-operative inflammation reaction and haze.

关键词

Keywords

references

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