Analysis of clinicopathology and CT features of histology subtypes of invasive lung adenocarcinoma

Xiaoqun HE; Tianyou LUO; Xian LI; Junwei GONG; Jiwen HUO; Qi LI

doi:10.16016/j.1000-5404.202004321

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Analysis of clinicopathology and CT features of histology subtypes of invasive lung adenocarcinoma

更新时间：2026-01-09

- Analysis of clinicopathology and CT features of histology subtypes of invasive lung adenocarcinoma
- Journal of Third Military Medical University Vol. 42, Issue 19, Pages: 1950-1956(2020)
- 作者机构：
- 作者简介：
- 基金信息：
  
  the Grant From the General Medical Research Project of Chongqing Municipal Health and Family Planning Commission(2017MSXM010);the Basic Science and Frontier Technology Research Project of Chongqing Science and Technology Commission(cstc2017jcyjAX0281)
- DOI：10.16016/j.1000-5404.202004321
  CLC：
- Received：30 April 2020，
  
  Published：15 October 2020
- 稿件说明：
移动端阅览
Xiaoqun HE, Tianyou LUO, Xian LI, et al. Analysis of clinicopathology and CT features of histology subtypes of invasive lung adenocarcinoma[J]. Journal of Third Military Medical University, 2020, 42(19): 1950-1956.
DOI：

Xiaoqun HE, Tianyou LUO, Xian LI, et al. Analysis of clinicopathology and CT features of histology subtypes of invasive lung adenocarcinoma[J]. Journal of Third Military Medical University, 2020, 42(19): 1950-1956. DOI： 10.16016/j.1000-5404.202004321.

摘要

Abstract

Objective

Objective To investigate the differences of clinicopathological characteristics and CT features in different histology subtypes of invasive lung adenocarcinoma (ILA)

and to find a noninvasive imaging method that can help to distinguish them.

Methods

A total of 422 patients confirmed with solitary ILA by surgical resection in our hospital from July 2013 to July 2019 were included. All patients were divided into group A (those with a lepidic/acinar/papillary predominant pattern) and group B (those with a solid/micropapillary predominant pattern) according to the main pathological growth pattern. Moreover

group A was divided into group A1 (those with a lepidic predominant pattern) and group A2 (those with an acinar / papillary predominant pattern). The clinicopathology and CT features between group A and group B as well as those between group A1 and group A2 were compared

respectively.

Results

1Comparison of clinicopathological characteristics between group A and B: Gender and smoking history of patients

as well as histologic differentiation

lymph node metastasis status and pathologic TNM stage of tumors significantly differed between the two groups (all

0.05). Patients with male and smoking

tumors with poor histology differentiation

lymph node metastasis

and pathologic TNM stage of III-IV were more frequently seen in group B. However

no significant difference in the distant metastasis was observed between the two groups (

0.05). 2Comparison of CT features between group A and B: Lesion size

density

vascular convergence sign

air bronchogram

calcification

necrosis and pleural effusion were associated with the histological subtypes (all

0.05). Tumors in Group B were significantly larger than those in Group A. In addition

tumors with solid density

calcification

necrosis and pleural effusion were more frequently observed in Group B

whereas those with vascular convergence sign and air bronchogram were more common in Group A. However

no significant associations were found between other CT features and histological subtypes

including the distribution of tumors

air space

speculation

lobulation

and pleural retraction (all

0.05). 3Comparison of clinicopathological characteristics and CT features between group A1 and A2: Tumors with subsolid density were more common in Group A1

while those with solid density were more common in Group A

2 (

0.001). However

no significant differences were found in other clinicopathological characteristics and CT features between the two groups (all

0.05).

Conclusion

For clinicopathological characteristics

male

smoking

poor histology differentiation

lymph node metastasis

and pathologic TNM stage of III-IV were more common in patients with a solid/micropapillary predominant pattern. For CT features

tumors with large size

solid density

calcification

necrosis and pleural effusion were more common in patients with a solid/micropapillary predominant pattern

whereas those with vascular convergence sign and air bronchogram were more common in patients with a lepidic/acinar/papillary predominant pattern.

关键词

Keywords

references

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