Analysis of re-positive nucleic acid conversion in patients recovered from COVID-19 in Tianjin

Ying ZHAO; Weishen WU; Haiyan HE; Zhaofei WEI; Guoping ZHANG

doi:10.16016/j.1000-5404.202003103

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Analysis of re-positive nucleic acid conversion in patients recovered from COVID-19 in Tianjin

Special Reports:Prevention and control of COVID-19(2) | 更新时间：2026-01-09

- Analysis of re-positive nucleic acid conversion in patients recovered from COVID-19 in Tianjin
- Journal of Third Military Medical University Vol. 42, Issue 9, Pages: 879-882(2020)
- 作者机构：
  
  300011 天津，天津市疾病预防控制中心新型冠状病毒肺炎疫情处置组
- 作者简介：
- 基金信息：
  
  the Scientific and Technological Tackling Project of Chongqing Emergency for COVID-19(2020)
- DOI：10.16016/j.1000-5404.202003103
  CLC： R373.1;R446.5;R563.1
- Received：10 March 2020，
  
  Revised：2020-03-28，
  
  Published：15 May 2020
- 稿件说明：
移动端阅览
Ying ZHAO, Weishen WU, Haiyan HE, et al. Analysis of re-positive nucleic acid conversion in patients recovered from COVID-19 in Tianjin[J]. Journal of Third Military Medical University, 2020, 42(9): 879-882.
DOI：

Ying ZHAO, Weishen WU, Haiyan HE, et al. Analysis of re-positive nucleic acid conversion in patients recovered from COVID-19 in Tianjin[J]. Journal of Third Military Medical University, 2020, 42(9): 879-882. DOI： 10.16016/j.1000-5404.202003103.

摘要

目的

对天津市确诊新型冠状病毒肺炎病例治愈出院后病毒核酸重新转阳病例进行分析。

方法

对中国疾病预防控制信息系统报告的天津市确诊新型冠状病毒肺炎109例出院患者中，8例核酸重新转阳的病例进行监测，包括病例流行病学史、发病时间、临床表现等调查并定期病毒核酸检测，分析流行病学特征。

结果

截至2020年3月7日，天津市确诊新型冠状病毒肺炎病例康复出院后病毒核酸转阳率为7.34%(8/109)。病毒核酸阳性的8例病程中位时间为20.5(14.0~28.0)d，与病毒核酸阴性病例相比差异无统计学意义。8份病毒核酸阳性样本中粪便标本或肛拭子占62.50%(5/8)，咽拭子占37.50%(3/8)。8例病例均有明确的流行病学史，核酸重新转阳时12.5%(1/8)出现临床症状，但均未造成续发传播。

结论

天津市新型冠状病毒肺炎病例出院后存在病毒核酸重新转阳的现象，未造成续发传播。建议治愈、隔离观察前增加粪便核酸检测指标，病例出院后定期进行核酸检测。

Abstract

Objective

To analyze the re-positive nucleic acid cases in patients recovered from coronavirus disease 2019 (COVID-19) in Tianjin

and to provide suggestions on making prevention and control strategies.

Methods

Among the 109 confirmed COVID-19 patients in Tianjin who were reported by the China Information System for Disease Control and Prevention

8 patients re-positive for nucleic acid test after discharge were enrolled in this study. Their conditions after discharge were monitored by our group

including epidemiology

onset time

symptoms

and results of regular viral nucleic acid test. The epidemiological characteristics were analyzed.

Results

As of March 7

2020

the positive rate of re-positive nucleic acid conversion in patients recovered from COVID-19 was 7.34% (8/109). The median days of disease was 20.5 (14.0~28.0) d in 8 re-positive cases

which was not statistically different from those with negative results after discharge. Among the viral nucleic acid-positive samples

fecal specimens or anal swabs accounted for 62.50% (5/8)

and throat swabs for 37.50% (3/8). All 8 cases had identified epidemiological history. When the nucleic acid re-positive

12.50% of them (1/8) had clinical symptoms

but they did not cause any secondary transmission.

Conclusion

Re-positiveness for nucleic acid test are found in the COVID-19 patients after discharge in Tianjin

but no one causes further transmission till now. It is recommended to add standards for fecal nucleic acid test during discharge and quarantine

regularly nucleic acid detection after the patient is discharged from the hospital.

关键词

Keywords

references

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