Functional brain abnormalities in male patients with hyperuricemia: a study by resting-state functional magnetic resonance imaging

Junhao HU; Si ZHANG; Weijie FAN; Guanghui LI; Bo LIU; Li WEN; Guangxian WANG; Lei ZHANG; Dong ZHANG

doi:10.16016/j.1000-5404.202003102

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Functional brain abnormalities in male patients with hyperuricemia: a study by resting-state functional magnetic resonance imaging

Neurosciences | 更新时间：2026-01-09

- Functional brain abnormalities in male patients with hyperuricemia: a study by resting-state functional magnetic resonance imaging
- Journal of Third Military Medical University Vol. 42, Issue 14, Pages: 1421-1427(2020)
- 作者机构：
  
  400037 重庆，陆军军医大学(第三军医大学)第二附属医院放射科
- 作者简介：
- 基金信息：
- DOI：10.16016/j.1000-5404.202003102
  CLC： R445.2;R589.7;R741
- Received：08 March 2020，
  
  Revised：2020-03-26，
  
  Published：30 July 2020
- 稿件说明：
移动端阅览
Junhao HU, Si ZHANG, Weijie FAN, et al. Functional brain abnormalities in male patients with hyperuricemia: a study by resting-state functional magnetic resonance imaging[J]. Journal of Third Military Medical University, 2020, 42(14): 1421-1427.
DOI：

Junhao HU, Si ZHANG, Weijie FAN, et al. Functional brain abnormalities in male patients with hyperuricemia: a study by resting-state functional magnetic resonance imaging[J]. Journal of Third Military Medical University, 2020, 42(14): 1421-1427. DOI： 10.16016/j.1000-5404.202003102.

摘要

目的

探讨男性高尿酸血症患者静息状态下脑功能变化情况，探索血尿酸(serum uric acid，SUA)升高引起患者情绪及认知改变的神经生物学机制。

方法

选取2019年1-12月经社区招募的未经药物治疗的男性高尿酸血症患者(高尿酸血症组)及健康对照(对照组)各41例，行空腹血尿酸检测、神经心理测试和静息态功能磁共振(resting-state functional magnetic resonance imaging，rs-fMRI)扫描。利用低频振幅(amplitude of low-frequency fluctuation，ALFF)方法找出两组之间存在活动差异的脑区，随后行基于种子点与全脑各体素间的功能连接(functional connectivity，FC)分析。

结果

与对照组比较，高尿酸血症组左颞下回ALFF值减低，双侧额下回ALFF升高。以左颞下回极值点设种子点，与双侧楔叶间的FC强度增强；以左额下回极值点设种子点，与左侧丘脑、右尾状核间的FC强度增强。血尿酸、神经心理及认知测试结果显示：血尿酸浓度与工作记忆反应时间呈正相关(

=0.320，

=0.041)，工作记忆准确率与左侧颞下回中的ALFF值呈正相关(

=0.535，

0.001)，执行功能准确率与左侧及右额下回的ALFF值呈正相关(

=0.461，

=0.002；

=0.566，

0.001)，此外，左侧额下回与左侧丘脑及右侧尾状核之间FC强度分别与睡眠质量评分及贝克抑郁量表评分呈负相关(

=-0.361，

=0.020；

=-0.343，

=0.028)。

结论

男性高尿酸血症患者在区域及网络水平上存在脑功能异常。

Abstract

Objective

To assess the brain functions and explore the neurobiological mechanism of emotional and cognitive changes in male patients with hyperuricemia.

Methods

Forty-one untreated male patients with hyperuricemia and 41 healthy control subjects were recraited through communities during

and all of them underwent examinations of fasting serum uric acid (SUA)

neuropsychological test and resting-state functional magnetic resonance imaging (rs-fMRI). The amplitude of low-frequency fluctuation (ALFF) was analyzed to determine the seed points

and the functional connections between the abnormal seed points and the voxels of the whole brain were analyzed.

Results

The patients with hyperuricemia showed significantly decreased ALFF in the left inferior temporal gyrus (ITG.L) and increased ALFF in the bilateral inferior frontal gyrus (IFG.B) compared with the control subjects. The FC intensity of the bilateral cuneus (CUN.B) was enhanced when the extreme point of ITG.L was chosen as the seed point; the intensity of functional connection between the left thalamus (THA.L) and the right caudate nucleus (CAU.R) was enhanced when the extreme point of the IFG.L was the seed point. The results of SUA analysis and neuropsychological and behavioral tests showed that SUA levels were inversely correlated with the working memory reaction time (

=0.320

=0.041)

and the ALFF in the ITG.L was positively correlated with the working memory accuracy (

=0.535

0.001). The ALFF in IFG.L and IFG.R was positively correlated with the accuracy of the executive function (

=0.461

=0.002;

=0.566

0.001

respectively); the strength of functional connection of the IFG.L with the THA.L and with the CAU.R was inversely correlated with sleep quality (

=-0.361

=0.020) and depressive state (

=-0.343

=0.028) of the patients

respectively.

Conclusion

Brain abnormalities at regional and network levels are present in male patients with hyperuricemia

and these findings provide new insights into the mechanisms underlying the cognitive and emotional changes in patients with hyperuricemia.

关键词

Keywords

references

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