Alteration of cerebral gray matter thickness in acromegaly: a magnetic resonance imaging study

Xiaoqing ZHANG; Xiaolin YANG

doi:10.16016/j.1000-5404.202003066

您当前的位置：

首页 >

文章列表页 >

Alteration of cerebral gray matter thickness in acromegaly: a magnetic resonance imaging study

Neurosciences | 更新时间：2026-01-09

- Alteration of cerebral gray matter thickness in acromegaly: a magnetic resonance imaging study
- Journal of Third Military Medical University Vol. 42, Issue 14, Pages: 1428-1433(2020)
- 作者机构：
  
  400037 重庆，陆军军医大学(第三军医大学)第二附属医院神经外科
- 作者简介：
- 基金信息：
- DOI：10.16016/j.1000-5404.202003066
  CLC： R445.2;R584.11;R749.24
- Received：05 March 2020，
  
  Revised：2020-03-24，
  
  Published：30 July 2020
- 稿件说明：
移动端阅览
Xiaoqing ZHANG, Xiaolin YANG. Alteration of cerebral gray matter thickness in acromegaly: a magnetic resonance imaging study[J]. Journal of Third Military Medical University, 2020, 42(14): 1428-1433.
DOI：

Xiaoqing ZHANG, Xiaolin YANG. Alteration of cerebral gray matter thickness in acromegaly: a magnetic resonance imaging study[J]. Journal of Third Military Medical University, 2020, 42(14): 1428-1433. DOI： 10.16016/j.1000-5404.202003066.

摘要

目的

应用基于脑表面分析(surface based analysis

SRA)的方法研究肢端肥大症患者磁共振脑结构图像，分析肢端肥大症患者各脑区灰质厚度的改变以及与临床资料的相关性。

方法

收集2015年1月27日至2019年6月30日我科30名肢端肥大症患者和30名健康成年人磁共振三维容积扰相梯度回波(three dimensions T1 spoiled gradient recalled

3D T1-SPGR)薄层扫描图像，运用Freesurfer软件进行分析，得出所有大脑灰质厚度数据，并进行对比分析，得到差异脑区，分析其与临床资料的相关性。

结果

与健康对照相比，肢端肥大症患者右侧额中回下部、右侧额中回上部、右侧中央前回、右侧缘上回、右侧楔前叶、右侧海马旁回、右侧梭状回和左侧内嗅皮层灰质厚度变薄，且右侧楔前叶和右侧海马旁回灰质厚度与汉密尔顿抑郁量表(Hamilton Depression Scale

HAMD)评分呈负相关，与血浆高水平生长激素(growth hormone

GH)和胰岛素样生长因子-1(insulin-like growth factor-1

IGF-1)水平呈负相关，灰质厚度变化与年龄无相关性。

结论

肢端肥大症患者存在多个脑区灰质厚度的变薄，可能是高水平的GH和IGF-1激素作用所致，其中右侧楔前叶和右侧海马旁回灰质厚度变薄与肢端肥大症患者抑郁症有关。

Abstract

Objective

To study the changes of cortical thickness in different brain regions in patients with acromegaly using surface-based analysis (SRA) and analyze the association of these changes with clinical findings of the patients.

Methods

Thirty patients with acromegaly and 30 healthy adults underwent magnetic resonance imaging (MRI) examination using a T1-weighted three-dimensional spoiled gradient recalled (3D SPGR) sequence. The MRI images were analyzed using Freesurfer software to determine the changes of cortical thickness in different brain regions of the patients relative to those in the healthy subjects

and the correlation of these changes with the clinical findings of the patients were analyzed.

Results

Compared with the healthy subjects

acromegalic patients had decreased cortical thickness in the right rostral middle frontal gyrus

the right caudal middle frontal gyrus

the right precentral gyrus

the right supramarginal gyrus

the right precuneus

the right parahippocampal gyrus

the right fusiform gyrus and the left olfactory cortex thickness. The cortical thickness in the right precuneus and the right parahippocampal gyrus were inversely correlated with Hamilton Depression Scale (HAMD) scores and levels of growth hormone (GH) and insulin-like growth factor 1 (IGF-1) but were not correlated with age of the patients.

Conclusion

The patients with acromegaly have decreased cortical thickness in multiple brain regions

possibly as a result of high levels of GH and IGF-1. The decreased cortical thickness in the right precuneus and the right parahippocampal gyrus is correlated with depression in acromegalic patients.

关键词

Keywords

references

ALSUMALI A, COTE D J, REGESTEIN Q R, et al . The impact of transsphenoidal surgery on neurocognitive function: a systematic review[J ] . J Clin Neurosci, 2017, 42: 1-6. DOI: 10.1016/j.jocn.2017.01.015.

SIEVERS C, DIMOPOULOU C, PFISTER H, et al . Prevalence of mental disorders in acromegaly: a cross-sectional study in 81 acromegalic patients[J ] . Clin Endocrinol (Oxf), 2009, 71(5): 691-701. DOI: 10.1111/j.136 5-2265.2009.03555.x.

PERTICHETTI M, SERIOLI S, BELOTTI F, et al . Pituitary adenomas and neuropsychological status: a systematic literature review[J ] . Neurosurg Rev, 2019. DOI: 10.1007/s10143-019-01134-z.

SCHMAAL L, HIBAR D P, SÄMANN P G, et al . Cortical abnormalities in adults and adolescents with major depression based on brain scans from 20 cohorts worldwide in the Enigma Major Depressive Disorder Working Group[J ] . Mol Psychiatry, 2017, 22(6): 900-909. DOI: 10.1038/mp.2016.60.

FISCHL B, SALAT D H, BUSA E, et al . Whole brain segmentation: automated labeling of neuroanatomical structures in the human brain[J ] . Neuron, 2002, 33(3): 341-355. DOI: 10.1016/s0896-6273(02)00569-x.

FISCHL B, DALE A M. Measuring the thickness of the human cerebral cortex from magnetic resonance images[J]. Proc Natl Acad Sci USA, 2000, 97(20): 11050-11055. DOI: 10.1073/pnas.200033797.

SIEVERS C, SÄMANN P G, DOSE T, et al . Macroscopic brain architecture changes and white matter pathology in acromegaly: a clinicoradiological study[J ] . Pituitary, 2009, 12(3): 177-185. DOI: 10.1007/s1110 2-008-0143-1.

JAWORSKA N, MACMASTER F P, GAXIOLA I, et al . A preliminary study of the influence of age of onset and childhood trauma on cortical thickness in major depressive disorder[J ] . Biomed Res Int, 2014, 2014: 410472. DOI: 10.1155/2014/410472.

TRUONG W, MINUZZI L, SOARES C N, et al . Changes in cortical thickness across the lifespan in major depressive disorder[J ] . Psychiatry Res, 2013, 214(3): 204-211. DOI: 10.1016/j.pscychresns.2013.09.003.

PAPMEYER M, GILES S, SUSSMANN J E, et al . Cortical thickness in individuals at high familial risk of mood disorders as they develop major depressive disorder[J ] . Biol Psychiatry, 2015, 78(1): 58-66. DOI: 10.1016/j.biopsych.2014.10.018.

BARTLETT E A, KLEIN D N, LI K Q, et al . Depression severity over 27 months in adolescent girls is predicted by stress-linked cortical morphology[J ] . Biol Psychiatry, 2019, 86(10): 769-778. DOI: 10.1016/j.biopsych.2019.04.027.

KOPCZAK A, STALLA G K, UHR M, et al . IGF-I in major depression and antidepressant treatment response[J ] . Eur Neuropsychopharmacol, 2015, 2 5(6): 864-872. DOI: 10.1016/j.euroneuro.2014.12.013.

BOT M, MILANESCHI Y, PENNINX B W, et al . Plasma insulin-like growth factor I levels are higher in depressive and anxiety disorders, but lower in antidepressant medication users[J ] . Psychoneuroendocrinology, 2016, 68: 148-155. DOI: 10.1016/j.psyneuen.2016.02.028.

FRANZ B, BUYSSE D J, CHERRY C R, et al . Insulin-like growth factor 1 and growth hormone binding protein in depression: a preliminary communication[J ] . J Psychiatr Res, 1999, 33(2): 121-127. DOI: 10.1016/s0022-3956(98)00066-1.

GERAEDTS V J, DIMOPOULOU C, AUER M, et al . Health outcomes in acromegaly: depression and anxiety are promising targets for improving reduced quality of life[J ] . Front Endocrinol (Lausanne), 2014, 5: 229. DOI: 10.3389/fendo.2014.00229.

BARCELÓ P, NICOLAU C, GAMUNDÍ A, et al . Comparing the behavioural effects of exogenous growth hormone and melatonin in young and old wistar rats[J ] . Oxid Med Cell Longev, 2016, 2016: 5863402. DOI: 10.1155/2016/5863402.

ASHPOLE N M, SANDERS J E, HODGES E L, et al . Growth hormone, insulin-like growth factor-1 and the aging brain[J ] . Exp Gerontol, 2015, 68: 76-81. DOI: 10.1016/j.exger.2014.10.002.

ROSÉN T, WIRÉN L, WILHELMSEN L, et al . Decreased psychological well-being in adult patients with growth hormone deficiency[J ] . Clin Endocrinol (Oxf), 1994, 40 (1): 111-116. DOI: 10.1111/j.1365-2265.1994.tb02452.x.

Views

下载量

CSCD

Alert me when the article has been cited

提交

Tools

Publicity Resources

Diffusion tensor imaging of patients with first-episode depression complicated by olfactory dysfunction

A voxel-based morphometric MRI study in middle-aged female patients with first-episode major depressive disorders

Differential diagnostic efficacy of tumor vascular habitats based on DSC-PWI between glioblastoma and solitary metastatic brain tumors

Quantitative assessment of early lumbar disc degeneration in patients with low back pain by T1rho magnetic resonance imaging

Value of DCE-MRI parameters for short-term prognosis of pharyngeal cancer after postoperative radiotherapy

Related Author

Junshi XIE

Qiuyi CAI

Fangyuan OU

Mingjing YUAN

Bing WEN

Liangbo HU

刘海霞

赵雯婧

Related Institution

Department of Radiology, Yongchuan Hospital Affiliated to Chongqing Medical University

Department of Radiology

Chongqing Clinical Research Centre of Imaging and Nuclear Medicine

Department of Pathology， Daping Hospital， Army Medical University

Department of Radiology， the First Affiliated Hospital of Chongqing Medical University

⁰