Change of insulin resistance in impaired fasting glucose patients with hypertension: a follow-up study of 5 years

Bo LANG; Shanshan DUAN; Weiling LENG; Li GUO; Ling LIU; Ping WEI

doi:10.16016/j.1000-5404.202003002

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Change of insulin resistance in impaired fasting glucose patients with hypertension: a follow-up study of 5 years

更新时间：2026-01-09

- Change of insulin resistance in impaired fasting glucose patients with hypertension: a follow-up study of 5 years
- Journal of Third Military Medical University Vol. 42, Issue 11, Pages: 1136-1140(2020)
- 作者机构：
- 作者简介：
- 基金信息：
- DOI：10.16016/j.1000-5404.202003002
  CLC：
- Received：01 March 2020，
  
  Published：15 June 2020
- 稿件说明：
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Bo LANG, Shanshan DUAN, Weiling LENG, et al. Change of insulin resistance in impaired fasting glucose patients with hypertension: a follow-up study of 5 years[J]. Journal of Third Military Medical University, 2020, 42(11): 1136-1140.
DOI：

Bo LANG, Shanshan DUAN, Weiling LENG, et al. Change of insulin resistance in impaired fasting glucose patients with hypertension: a follow-up study of 5 years[J]. Journal of Third Military Medical University, 2020, 42(11): 1136-1140. DOI： 10.16016/j.1000-5404.202003002.

摘要

Abstract

Objective

To observe the change of insulin resistance in the impaired fasting glucose patients with hypertension along with time elapse

and to investigate the relationship between hypertension and insulin resistance.

Methods

A total of 180 patients with impaired fasting glucose admitted in our outpatient department of endocrinology and physical examination center of our hospital during October 2012 and August 2013 were recruited in this study. All of them were given long-term lifestyle intervention

and were followed up for 5 years. Till the end of the follow-up

there were 114 patients included

and they were divided into the hypertension group (

=56) and the normal blood pressure group (

=58). Routine antihypertensive drugs were given to the hypertension group. Clinical data

such as fasting blood glucose

2 h postprandial blood glucose

fasting insulin

2 h postprandial insulin

and insulin resistance index (HOMA-IR) and insulin sensitivity index (ISI) from the third to the fifth year of follow-up w

ere collected and analyzed.

Results

In the 5 years' follow-up

the prevalence of diabetes in the hypertension group was 22.83%

significantly higher than that of the normal blood pressure group (11.36%

=0.042). The hypertension group had obviously higher HOMA-IR but statistically lower ISI when compared with the normal blood pressure group (both

0.001).

Conclusion

In the patients with impaired fasting glucose

elevated blood pressure is closely associated with insulin resistance. As time goes by

those impaired fasting glucose accompanied with hypertension are more prone to severe insulin resistance

and are more likely to progress to diabetes.

关键词

Keywords

references

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