Current status and countermeasures for development of drugs to treat coronavirus disease 2019

Quanming ZOU; Haibo LI; Hao ZENG

doi:10.16016/j.1000-5404.202002233

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Current status and countermeasures for development of drugs to treat coronavirus disease 2019

Special Reports:Prevention and control of COVID-19(2) | 更新时间：2026-01-09

- Current status and countermeasures for development of drugs to treat coronavirus disease 2019
- Journal of Third Military Medical University Vol. 42, Issue 9, Pages: 861-866(2020)
- 作者机构：
  
  400038 重庆，陆军军医大学(第三军医大学)药学与检验医学系微生物与生化药学教研室，国家免疫生物制品工程技术研究中心
- 作者简介：
- 基金信息：
  
  the General Program of National Natural Science Foundation of China(31670936);the Scientific and Technological Tackling Project of Chongqing Emergency for COVID-19(2020)
- DOI：10.16016/j.1000-5404.202002233
  CLC： R563.106;R978.7
- Received：29 February 2020，
  
  Revised：2020-03-04，
  
  Published：15 May 2020
- 稿件说明：
移动端阅览
Quanming ZOU, Haibo LI, Hao ZENG. Current status and countermeasures for development of drugs to treat coronavirus disease 2019[J]. Journal of Third Military Medical University, 2020, 42(9): 861-866.
DOI：

Quanming ZOU, Haibo LI, Hao ZENG. Current status and countermeasures for development of drugs to treat coronavirus disease 2019[J]. Journal of Third Military Medical University, 2020, 42(9): 861-866. DOI： 10.16016/j.1000-5404.202002233.

摘要

自新型冠状病毒(SARS-CoV-2)疫情发生以来，国内外多家研究机构投入到抗新型冠状病毒肺炎(简称新冠肺炎，coronavirus disease 2019

COVID-19)的药物研发中。目前主要采取老药新用的策略，筛选抗新冠病毒和抑制过度免疫反应的候选药物，相关研究已经取得了重要进展。本文在综述已经纳入国家卫健委印发的新型冠状病毒肺炎诊疗方案中以及在体外已经证实对新型冠状病毒具有抑制作用的药物研发和临床应用的现状的基础上，对未来新冠肺炎治疗药物的研究对策提出建议:①从“老药新用”策略向创新药物研发转变；②构建可靠的体内外药物筛选模型；③建立新冠肺炎药物研发的协同创新机制；④有序开展新冠肺炎的药物临床试验；⑤建立冠状病毒研发的长效机制。

Abstract

Since the outbreak of the epidemic caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)

or 2019 novel coronavirus (2019-nCoV) provisionally

many research institutions at home and abroad have involved in t

he research and development (R

D) of drugs against coronavirus disease 2019 (COVID-19). At present

the strategy of new use of old drugs is used to screen candidate drugs which inhibit the virus or excessive immune response

and the related researches have made important progress. This article reviewed current status of development and clinical application of those drugs which have been included in the diagnosis of novel coronavirus-infected pneumonia and treatment protocols which have been shown to inhibit the virus

in vitro

. In addition

we have following suggestions for future researches on the development of novel drugs against COVID-19: ① from "new use of old drugs" strategy to innovative drug R

D; ② building reliable models for screening drugs

in vitro

and

in vivo

; ③establishing a synergistic innovation mechanism for drug R

D against COVID-19; ④conducting clinical trials of the drugs in order; ⑤ establishing a long-term mechanism for drug R

D against COVID-19.

关键词

Keywords

references

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