Pay attention to 2019 coronavirus disease (COVID-19) induced sepsis immuno-suppression

Hong Zhou; Xiaoli LI; Bin LI

doi:10.16016/j.1000-5404.202002172

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Pay attention to 2019 coronavirus disease (COVID-19) induced sepsis immuno-suppression

更新时间：2026-01-09

- Pay attention to 2019 coronavirus disease (COVID-19) induced sepsis immuno-suppression
- Journal of Third Military Medical University Vol. 42, Issue 6, Pages: 539-544(2020)
- 作者机构：
- 作者简介：
- 基金信息：
  
  Supported by the General Program of National Natural Science Foundation of China(81872914);Supported by the General Program of National Natural Science Foundation of China(81673495);and the Project for National Major New Drug Research and Development(2017ZX09101002-002-009)
- DOI：10.16016/j.1000-5404.202002172
  CLC：
- Received：24 February 2020，
  
  Published：2020
- 稿件说明：
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Hong Zhou, Xiaoli LI, Bin LI. Pay attention to 2019 coronavirus disease (COVID-19) induced sepsis immuno-suppression[J]. Journal of Third Military Medical University, 2020, 42(6): 539-544.
DOI：

Hong Zhou, Xiaoli LI, Bin LI. Pay attention to 2019 coronavirus disease (COVID-19) induced sepsis immuno-suppression[J]. Journal of Third Military Medical University, 2020, 42(6): 539-544. DOI： 10.16016/j.1000-5404.202002172.

摘要

Abstract

2019 coronavirus disease (COVID-19) is an infectious disease caused by SARS-COV-2 virus

and lacks specifically effective treatment till now. Its clinical manifestations and the concerning studies at home and abroad have shown that viral sepsis caused by SARS-COV-2 virus has typical characteristics of pathophysiology of sepsis

that is

early cytokine storm and subsequent immunosuppression stage. At present

although great attention has been paid to the treatment and clinical research on cytokine storm

the later stage of immunosuppression is neglected. Patients' lower immunity

secondary infection and multiple organ failure are quite common

and all these lead to rapid deterioration and even death. Therefore

it is of great significance to pay attention to the investigation and treatment of sepsis immunosuppression stage caused by COVID-19

and to study the drugs with bidirectional immune regulation such as artesunate so as order to reduce the mortality of patients with severe or critical COVID-19. What's more

we strongly recommend that chloroquine phosphate should be used with great caution for severe and critical patients.

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references

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