Clinical analysis of 49 cases of coronavirus disease 2019 in Shiyan, Hubei Province

Qin ZHAO; Xu LEI; Long LIU; Guoqing ZHAN; Rugui LI; Jinke LI; Fang LI; Weixing DU; Jian LI; Jing YANG; Huabing TAN

doi:10.16016/j.1000-5404.202002107

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Clinical analysis of 49 cases of coronavirus disease 2019 in Shiyan, Hubei Province

Special Reports:Prevention and control of COVID-19(2) | 更新时间：2026-01-09

- Clinical analysis of 49 cases of coronavirus disease 2019 in Shiyan, Hubei Province
- Journal of Third Military Medical University Vol. 42, Issue 9, Pages: 867-871(2020)
- 作者机构：
  
  1.442000 湖北十堰，十堰市人民医院(湖北医药学院附属人民医院)感染性疾病科，湖北医药学院肝病研究所
  2.442100 湖北房县，房县人民医院检验科
- 作者简介：
- 基金信息：
  
  the Tackling Project of Science and Technology Research of Shiyan City in 2019(19K67);the Guiding Emergency Research Project for COVID-19 Prevention and Control of Shiyan City in 2020(20Y34);the Special Research of Novel Coronavirus Pneumonia Emergency Research in Hubei Medical College(2020XGFYZR16)
- DOI：10.16016/j.1000-5404.202002107
  CLC： R181.32;R373.1;R563.19
- Received：17 February 2020，
  
  Revised：2020-03-05，
  
  Published：15 May 2020
- 稿件说明：
移动端阅览
Qin ZHAO, Xu LEI, Long LIU, et al. Clinical analysis of 49 cases of coronavirus disease 2019 in Shiyan, Hubei Province[J]. Journal of Third Military Medical University, 2020, 42(9): 867-871.
DOI：

Qin ZHAO, Xu LEI, Long LIU, et al. Clinical analysis of 49 cases of coronavirus disease 2019 in Shiyan, Hubei Province[J]. Journal of Third Military Medical University, 2020, 42(9): 867-871. DOI： 10.16016/j.1000-5404.202002107.

摘要

目的

分析湖北省十堰市新型冠状病毒肺炎(coronavirus disease 2019

COVID-19)临床特点，并与近期收治流行性感冒(12例合并肺炎)患者进行比较。

方法

收集十堰市人民医院(湖北医药学院附属人民医院)2020年1月23日至2月9日确诊的49例COVID-19患者(COVID-19组)，分析其临床表现、流行病学史、实验室检查、螺旋CT(MSCT)检查结果，并与2019年12月1日至2020年1月31日治疗的31例流行性感冒(12例合并肺炎)组(流感组)进行比较和分析。

结果

(1) 发热和体温变化:COVID-19组以发热为主诉占87.76%，低于流感组(96.77%，

0.05)；COVID-19组以低热(

22例)、中度发热(21例)为主，与流感组以中度发热(12例)、高热(18例)为主不同(

0.05)。(2)咳嗽、咳痰:COVID-19组咳嗽、咳痰发生率为65.31%，低于流感组(93.55%，

0.01)。(3)喷嚏、流涕:COVID-19组喷嚏、流涕发生率为2.04%，低于流感组(96.77%，

0.001)。(4)气促、胸闷:COVID-19组发生率为12.24%，低于流感组(29.03%，

0.05)。(5)乏力、纳差:COVID-19组发生率为34.69%，高于流感组(6.45%，

0.01)。(6)腹泻:COVID-19组发生率为6.12%，流行性感冒(12例合并肺炎)组无腹泻病例。(7)白细胞计数(WBC):COVID-19组WBC低于正常发生率为77.55%，高于流感组(16.13%，

0.01)。(8)淋巴细胞计数:COVID-19组淋巴细胞计数低于正常发生率为38.78%，高于流感组(6.45%，

0.01)。(9)COVID-19组MSCT表现:1~3次MSCT检查，病灶位于双侧占91.84%，具有典型影像学表现。(10)新型冠状病毒核酸检测:第1次阳性率为77.55%，第2次总阳性率为89.80%，第3次总阳性率为97.96%，第4次阳性率为100%。

结论

与流行性感冒相比，十堰地区COVID-19发热以低至中度为主，畏寒少见；干咳，咳痰少见；喷嚏、流涕极少见；WBC下降、淋巴细胞下降发生率不高；诊断需结合临床、流行病学、核酸检查和MSCT表现。

Abstract

Objective

To analyze the clinical characteristics of coronavirus disease 2019 (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in Shiyan

Hubei Province

and to compare the features with those of the recent treatment of influenza.

Methods

Forty-nine diagnosed COVID-19 patients admitted to the People's Hospital of Shiyan City from January 23 to February 9

2020 were recruited in this study. Their clinical manifestations

epidemiological history

results of laboratory tests

and images of multi-slice CT (MSCT) examination were collected and analyzed

and the results were compared with the features of 31 cases of influenza virus infection (12 cases

accompanying pneumonia) during the same period.

Results

① Fever and body temperature: Fever was the main complaint of the COVID-19 patients (87.76%)

and the rate was significant lower than the influenza group (96.77%

0.05). The COVID-19 group had low fever (22 cases) and moderate fever (21 cases) which were mainly dif

ferent from those with moderate fever (12 cases) and high fever (18 cases) in the influenza group (

0.05). ② Cough and sputum: The incidence of cough and sputum was 65.31% in the COVID-19 group

which was significantly lower than that of the influenza group (93.55%

0.01). ③ Sneezing and rhinorrhea: The incidence in the COVID-19 group was 2.04%

obviously lower than that of the influenza group (96.77%

0.001). ④ Shortness of breath and chest tightness: The incidence was 12.24% in the COVID-19 group

and 29.03% in the influenza group (

0.05). ⑤ Fatigue and anorexia: The incidence rate was 34.69% in COVID-19 group

significantly higher than that of the influenza group (6.45%

0.01). ⑥ Diarrhea: The incidence rate was 6.12% in the COVID-19 group

and no case was seen in the influenza group. ⑦ WBC count: The COVID-19 patients having a lower WBC count accounted for 77.55%

which was lower than the health control but higher than that of the influenza group (16.13%

0.01). ⑧ Lymphocyte count: 38.78% COVID-19 patients had a lower lymphocyte ratio

but only 6.45% in the influenza group (

0.01). ⑨ Multi-slice CT (MSCT): All COVID-19 patients underwent 1 to 3 times of MSCT examination

and typical imaging features (bilateral lesions) were found in 91.84% patients. ⑩ Nucleic acid test: 77.55% patients were positive in the first time

89.80% was in the second

97.96% in the third

and 100% in the fourth.

Conclusion

Compared with influenza

COVID-19 are characterized by mainly low to moderate fever

rare chills

dry cough and sputum

very rear sneezing and runny nose

decreased WBC count

and not higher incidence of lymphocyte decline. The diagnosis needs based on the combination of clinical manifestation

epidemiological data

nucleic acid test and MSCT findings.

关键词

Keywords

references

[国家卫生健康委员会.中华人民共和国国家卫生健康委员会公告[2020年第1号 ] .[2020-01-20 ] . http://www.nhc.gov.cn/jkj/s7916/202001/44a3b8245e8049d2837a4f27529cd386.shtml http://www.nhc.gov.cn/jkj/s7916/202001/44a3b8245e8049d2837a4f27529cd386.shtml .

[National Health Commission of the People's Republic of China. Announcement of the National Health Commission of the People's Republic of China[2020 No. 1 ] .[2020-01-20 ] . http://www.nhc.gov.cn/jkj/s7916/202001/44a3b8245e8049d2837a4f27529cd386.shtml http://www.nhc.gov.cn/jkj/s7916/202001/44a3b8245e8049d2837a4f27529cd386.shtml .

LI Q, GUAN X, WU P, et al . Early transmission dynamics in Wuhan, China, of novel coronavirus-infected pneumonia[J ] . N Engl J Med, 2020, 382:1199-1207. DOI:10.1056/NEJMoa2001316.

[国家卫生健康委办公厅, 国家中医药管理局办公室.新型冠状病毒肺炎诊疗方案(试行第三版).[2020-01-28 ] . http://www.nhc.gov.cn/xcs/zhengcwj/202001/470b128513fe46f086d79667db9f76a5.shtml http://www.nhc.gov.cn/xcs/zhengcwj/202001/470b128513fe46f086d79667db9f76a5.shtml .

[General Office of National Health Commission of the People's Republic of China, Office of State Administration of Traditional Chinese Medicine. Novel coronavirus pneumonia treatment plan (Trial Third Edition).[2020-01-28 ] . http://www.nhc.gov.cn/xcs/zhengcwj/202001/470b128513fe46f086d79667db9f76a5.shtml http://www.nhc.gov.cn/xcs/zhengcwj/202001/470b128513fe46f086d79667db9f76a5.shtml .

[国家卫生健康委办公厅, 国家中医药管理局办公室.新型冠状病毒肺炎诊疗方案(第四版).[2020-01-27 ] . http://www.gov.cn/zhengce/zhengceku/2020-01/28/content_5472673.htm http://www.gov.cn/zhengce/zhengceku/2020-01/28/content_5472673.htm .

[General Office of National Health Commission of the People's Republic of China, Office of State Administration of Traditional Chinese Medicine. Novel coronavirus pneumonia treatment plan (Trial Fourth Edition).[2020-01-27 ] . http://www.gov.cn/zhengce/zhengceku/2020-01/28/content_5472673.html http://www.gov.cn/zhengce/zhengceku/2020-01/28/content_5472673.html .

[国家卫生健康委办公厅, 国家中医药管理局办公室.新型冠状病毒肺炎诊疗方案(第五版).[2020-02-04 ] . http://www.gov.cn/zhengce/zhengceku/2020-02/05/content_5474791.htm http://www.gov.cn/zhengce/zhengceku/2020-02/05/content_5474791.htm .

[General Office of National Health Commission of the People's Republic of China, Office of State Administration of Traditional Chinese M edicine. Novel coronavirus pneumonia treatment plan (Trial Fifth Edition).[2020-02-04 ] . http://www.gov.cn/zhengce/zhengceku/2020-02/05/content_5474791.htm http://www.gov.cn/zhengce/zhengceku/2020-02/05/content_5474791.htm .

[国家卫生健康委办公厅, 国家中医药管理局办公室.新型冠状病毒肺炎诊疗方案(第六版).[2020-02-18 ] . http://www.gov.cn/zhengce/zhengceku/2020-02/19/content_5480948.htm http://www.gov.cn/zhengce/zhengceku/2020-02/19/content_5480948.htm .

[General Office of National Health Commission of the People's Republic of China, Office of State Administration of Traditional Chinese Medicine. Novel coronavirus pneumonia treatment plan (Trial Sixth Edition).[2020-02-18 ] . http://www.gov.cn/zhengce/zhengceku/2020-02/19/content_5480948.htm http://www.gov.cn/zhengce/zhengceku/2020-02/19/content_5480948.htm .

国家卫生和计划生育委员会, 国家中医药管理局.流行性感冒诊疗方案(2018年版)[J].中国感染控制杂志, 2018, 17(2): 181-184. DOI:10.3969/J.issn.1671-9638.2018.02.020.

National Health and Family Planning Commission, State Administration of Traditional Chinese Medicine. Influenza diagnosis and treatment plan (2018 edition)[J]. Chin J Infection Control, 2018, 17 (2): 181-184. DOI:10.3969/J.issn.1671-9638.2018.02.020.

李进, 李文全, 聂滨, 等.输入型难辨性新型冠状病毒肺炎一例及传播模式分析[J].华西医学杂志, 2020, 35(2):137-140. DOI: 10.7507/1002-0179.202002001.

LI J, LI W Q, NIE B, et al . Analysis of a case of pneumonia and transmission mode of imported indistinct coronavirus infection[J ] . West China Med J, 2020, 35 (2): 137-140. DOI: 10.7507/1002-0179.202002001.

马卓娅, 郑跃杰, 刘萍, 等.深圳市儿童医院急性呼吸道感染患儿人冠状病毒感染情况分析[J].中华实用诊断与治疗杂志, 2014, 28(2): 140-141. DOI:10.13507/j.issn.1674-3474.2014.02.014.

MA Z Y, ZHENG Y J, LIU P, et al . Detection of human coronaviruses in children with acute respiratory tract infection in Shenzhen Children's Hospital[J ] . J Chin Pract Diagn Ther, 2014, 28(2): 140-141. DOI:10.13507/j.issn.1674-3474.2014.02.014.

朱娜, 耿合员, 陈涛.粪-口途径:不为人知的中东呼吸综合征冠状病毒传播的新途径[J].热带病与寄生虫学, 2017, 15(4): 187-189.

ZHU N, GENG H Y, CHEN T. Facal-oral Transmission: an ignored alternative infection route for Middle East respiratory syndrome coronavirus[J]. J Trop Dis Parasitol, 2017, 15(4): 187-189.

ZHOU J, LI C, ZHAO G Y, et al . Human intestinal tract serves as an alternative infection route for Middle East respiratory syndrome coronavirus[J ] . Sci Adv, 2017, 3(11): eaao4966. DOI:10.1126/sciadv.aao4966.

欧阳芬, 吴荷玉, 杨英, 等.新型冠状病毒肺炎快速传播的应对措施[J].全科护理杂志, 2020, 18(3):311-312. DOI:10.12104/j.issn.1674-4748.2020.03.02.

OU Y F, WU H Y, YANG Y, et al . Response measures based on the rapid spread of Wuhan new coronavirus pneumonia[J ] . J General Nurs, 2020, 18 (3) :311-312. DOI:10.12104/j.issn.1674-4748.2020.03.02.

管汉雄, 熊颖, 申楠茜, 等.新型冠状病毒肺炎(COVID-19)临床影像学特征[J].放射学实践, 2020, 35(2): 125-130. DOI: 10.13609/j.cnki.1000-0313.2020.02.001.

GUAN H X, XIONG Y, SHEN N Q, et al . Clinical imaging characteristics of new 2019 coronavirus (2019-nCoV) pneumonia in Wuhan[J ] . Radiol Pract, 2020, 35(2): 125-130. DOI: 10.13609 /j.cnki.1000-0313.2020.02.001.

[李太生, 曹玮, 翁利, 等.北京协和医院关于"新型冠状病毒感染的肺炎"诊疗建议方案(V2.0)[J ] .协和医学杂志, 2020. http://kns.cnki.net/kcms/detail/11.5882.r.20200130.1430.002.html http://kns.cnki.net/kcms/detail/11.5882.r.20200130.1430.002.html .

[LI T S, CAO W, WENG L, et al . Recommendations for diagnosis and treatment of "new coronavirus-infected pneumonia" in Beijing Union Medical College Hosp (V2.0)[J ] . Med J Peking Union Med College Hospital, 2020. http://kns.cnki.net/kcms/detail/11.5882.r.20200130.1430.002.html http://kns.cnki.net/kcms/detail/11.5882.r.20200130.1430.002.html ..

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