Clinical features of coronavirus disease 2019 in Northeast area of Chongqing: analysis of 143 cases

Yajuan CHEN; Lili SHUI; Xiaohua PANG; Huaming MOU; Jianbing WANG; Chunhui LANG; Jinglong LYU; Kai SUN; Wenfa LI; Kaihu XIAO

doi:10.16016/j.1000-5404.202002097

您当前的位置：

首页 >

文章列表页 >

Clinical features of coronavirus disease 2019 in Northeast area of Chongqing: analysis of 143 cases

更新时间：2026-01-09

- Clinical features of coronavirus disease 2019 in Northeast area of Chongqing: analysis of 143 cases
- Journal of Third Military Medical University Vol. 42, Issue 6, Pages: 549-554(2020)
- 作者机构：
- 作者简介：
- 基金信息：
  
  Supported by the Starting Project of Planned Innovation for Overseas Returnee in 2018(cx2018141)
- DOI：10.16016/j.1000-5404.202002097
  CLC：
- Received：15 February 2020，
  
  Published：30 March 2020
- 稿件说明：
移动端阅览
Yajuan CHEN, Lili SHUI, Xiaohua PANG, et al. Clinical features of coronavirus disease 2019 in Northeast area of Chongqing: analysis of 143 cases[J]. Journal of Third Military Medical University, 2020, 42(6): 549-554.
DOI：

Yajuan CHEN, Lili SHUI, Xiaohua PANG, et al. Clinical features of coronavirus disease 2019 in Northeast area of Chongqing: analysis of 143 cases[J]. Journal of Third Military Medical University, 2020, 42(6): 549-554. DOI： 10.16016/j.1000-5404.202002097.

摘要

Abstract

Objective

To explore the clinical features of 143 patients suffering from coronavirus disease 2019 (COVID-19) in the Northeast area of Chongqing.

Methods

A total of 143 COVID-19 patients who were positive to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) by nucleic acid test in nasopharyngeal swab and had typical CT characteristics of the novel coronavirus-infected pneumonia from Jan. 23 to Feb. 8 in 2020 were recruited in this study. Their epidemiology and clinical features were collected and retrospectively analyzed. And the differences in laboratory results were compared among the groups of different clinical classification. The treatment and clinical outcomes were also analyzed.

Results

Among the 143 patients with confirmed COVID-19

76 of them (76/143

53.1%) came from the epidemic area

Wuhan

52 (36.4%) had the contact history with the infected cases

and 15(10.5%) had no contact history of with those from epidemic areas. According to their conditions

they were assigned into ordinary group (

=107

74.8%)

severe group (

=24

16.8%) and critical group (

=12

8.4%). Their main clinical symptoms were fever

cough

headache and fatigue. And

11 patients had no clinical symptoms. The most common comorbidities were hypertension and diabetes

followed by chronic gastritis

hepatitis B and tuberculosis. Laboratory results indicated that the patients with decreased WBC accounted for 25.8%

and those with decreased for 44.8% in all the patients. The more severe the condition was

the lower lymphocyte count was decreased

and significant differences were seen in the count among the 3 groups (

0.05). The serum levels of C-reactive protein (CRP)

procalcitonin (PCT) and IL-6 rose when compared with the normal levels

and the increments were associated with the severity of the disease

with statistical difference among the 3 groups (

0.05).

Conclusion

No specific manifestations are identified in COIVD-19

and some patients may have no symptoms. But chest abnormal views of multiple macular patches and interstitial changes could be observed in early stage of this disease. For those who have contact history with the infected or suspected

nucleic acid test and chest radiology should be performed as early as possible. The absolute decrease of peripheral blood lymphocyte count is an index for the severity and prognosis of the disease. The dynamic follow-up of CRP

IL-6 and PCT can be used to make prediction for severe disease in the early stage and be helpful in guidance of treatment. Complicated metabolic and cardiovascular diseases are the risk factors for poor prognosis.

关键词

Keywords

references

中国疾病预防控制中心新型冠状病毒肺炎应急响应机制流行病学组.新型冠状病毒肺炎流行病学特征分析中华流行病学杂志 2020 41 2 145 151 中国疾病预防控制中心新型冠状病毒肺炎应急响应机制流行病学组.新型冠状病毒肺炎流行病学特征分析[J].中华流行病学杂志, 2020, 41(2): 145-151.

Epidemiology Working Group for NCIP Epidemic Response of Chinese Center for Disease Control and Prevention.The epidemiology characteristics of an outbreak of 2019 novel coronavirus disease(COVID-19)in China Chin J Epidemiol, 2020 41 2 145 151 Epidemiology Working Group for NCIP Epidemic Response of Chinese Center for Disease Control and Prevention. The epidemiology characteristics of an outbreak of 2019 novel coronavirus disease(COVID-19)in China[J], Chin J Epidemiol, 2020, 41(2): 145-151.

WHO . Laboratory diagnostics for novel coronavirus [OL ] . https://www.who.int/health-topics/coronavirus/laboratory-diagnostics-for-novel-coronavirus. WHO. Laboratory diagnostics for novel coronavirus[OL]. https://www.who.int/health-topics/coronavirus/laboratory-diagnostics-for-novel-coronavirus.

GUAN W NI Z HU Y Clinical characteristics of 2019 novel coronavirus infection in China medRxiv 2020-02-09 10.1101/2020.02.06.20020974 GUAN W, NI Z, HU Y, <italic>et al</italic>. Clinical characteristics of 2019 novel coronavirus infection in China[J/OL]. medRxiv, 2020-02-09. https://www.medrxiv.org/content/10.1101/2020.02.06.20020974v1. DOI: 10.1101/2020.02.06.20020974.

HUANG C L WANG Y M LI X W Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China Lancet 2020 395 10223 497 506 10.1016/s0140-6736(20)30183-5 HUANG C L, WANG Y M, LI X W, et al . Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China[J ] . Lancet, 2020, 395(10223): 497-506. DOI: 10.1016/s0140-6736(20)30183-5.

WANG D W HU B HU C Clinical characteristics of 138 hospitalized patients with 2019 novel coronavirus-infected pneumonia in Wuhan, China JAMA 2020 10.1001/jama.2020.1585 WANG D W, HU B, HU C, et al . Clinical characteristics of 138 hospitalized patients with 2019 novel coronavirus-infected pneumonia in Wuhan, China[J ] . JAMA, 2020. DOI: 10.1001/jama.2020.1585.

XU X W WU XX JIANG X G Clinical findings in a group of patients infected with the 2019 novel coronavirus (SARS-Cov-2) outside of Wuhan, China: retrospective case series BMJ 2020 368 m606 10.1136/bmj.m606 XU X W, WU XX, JIANG X G, et al . Clinical findings in a group of patients infected with the 2019 novel coronavirus (SARS-Cov-2) outside of Wuhan, China: retrospective case series[J ] . BMJ, 2020, 368: m606. DOI:10.1136/bmj.m606.

WONG C K LAM C W WU A K Plasma inflammatory cytokines and chemokines in severe acute respiratory syndrome Clin Exp Immunol 2004 136 1 95 103 10.1111/j.1365-2249.2004.02415.x WONG C K, LAM C W, WU A K, et al . Plasma inflammatory cytokines and chemokines in severe acute respiratory syndrome[J ] . Clin Exp Immunol, 2004, 136(1): 95-103. DOI: 10.1111/j.1365-2249.2004.02415.x.

MAHALLAWI W H KHABOUR O F ZHANG Q B MERS-CoV infection in humans is associated with a proinflammatory Th1 and Th17 cytokine profile Cytokine 2018 104 8 13 10.1016/j.cyto.2018.01.025 MAHALLAWI W H, KHABOUR O F, ZHANG Q B, et al . MERS-CoV infection in humans is associated with a proinflammatory Th1 and Th17 cytokine profile[J ] . Cytokine, 2018, 104: 8-13. DOI: 10.1016/j.cyto.2018.01.025.

Views

下载量

CSCD

Alert me when the article has been cited

提交

Tools

Publicity Resources

Concern over global outbreak of acute severe hepatitis of unknown etiology in children

Clinical characteristics of IgG4-related disease: analysis of 29 cases

Clinical characteristics and diagnostic strategies of pulmonary cryptococcosis: an analysis of 24 cases

Clinical characteristics of regional portal hypertension in 3 576 patients: a systematic analysis

Genotypic characteristics of multidrug-resistant Mycobacterium tuberculosis in Chongqing

Related Author

Songtao ZHAO

Qing MAO

Bingjing ZHU

Haiqin GUO

Chunlan TANG

Caixia DENG

Xiaohan HUANG

Hu LUO

Related Institution

Institute of Infectious Diseases, Chongqing Key Laboratory of Infectious Diseases Research, First Affiliated Hospital, Army Medical University (Third Military Medical University)

Department of Respiratory and Critical Care Medicine, First Affiliated Hospital, Army Medical University (Third Military Medical University)

Department of Gastroenterology, Daping Hospital, Army Medical University (Third Military Medical University)

Department of Gastroenterology, Hechuan District People's Hospital

Department of Clinical Laboratory, Chongqing Public Health Medical Center

⁰