Clinicopathological features and prognostic differences of ductal carcinoma <italic style="font-style: italic">in situ</italic> with ductal carcinoma <italic style="font-style: italic">in situ</italic> with microinvasion

Jing LIU; Ye ZHANG; Wenting YAN; Ling ZHONG; Xuanni TAN; Ting ZHANG; Kongyong ZHANG; Qingqiu CHEN; Yi ZHANG; Jun JIANG; Xiaowei QI

doi:10.16016/j.1000-5404.202002067

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Clinicopathological features and prognostic differences of ductal carcinoma in situ with ductal carcinoma in situ with microinvasion

Clinical Medicine | 更新时间：2026-01-09

- Clinicopathological features and prognostic differences of ductal carcinoma in situ with ductal carcinoma in situ with microinvasion
- Journal of Third Military Medical University Vol. 42, Issue 13, Pages: 1355-1359(2020)
- 作者机构：
  
  400038 重庆, 陆军军医大学(第三军医大学)第一附属医院乳腺甲状腺外科
- 作者简介：
- 基金信息：
  
  the Promotion Plan for Military Medical Innovation Capacity of the First Affiliated Hospital of Army Medical University(SWH2018BJLC-04);the Medical Talent Cultivation Project of Army Medical University(XZ-2019-505-042)
- DOI：10.16016/j.1000-5404.202002067
  CLC： R181.32;R730.43;R737.9
- Received：12 February 2020，
  
  Revised：2020-04-27，
  
  Published：15 July 2020
- 稿件说明：
移动端阅览
Jing LIU, Ye ZHANG, Wenting YAN, et al. Clinicopathological features and prognostic differences of ductal carcinoma in situ with ductal carcinoma in situ with microinvasion[J]. Journal of Third Military Medical University, 2020, 42(13): 1355-1359.
DOI：

Jing LIU, Ye ZHANG, Wenting YAN, et al. Clinicopathological features and prognostic differences of ductal carcinoma in situ with ductal carcinoma in situ with microinvasion[J]. Journal of Third Military Medical University, 2020, 42(13): 1355-1359. DOI： 10.16016/j.1000-5404.202002067.

摘要

目的

探讨乳腺导管原位癌(ductal carcinoma in situ

DCIS)和导管原位癌伴微浸润(ductal carcinoma in situ with microinvasion

DCIS-MI)的临床病理特征及预后差异。

方法

收集2004年1月至2014年12月本院乳腺甲状腺外科489例手术确诊为DCIS或DCIS-MI女性患者

其中DCIS患者240例(49.1%)

DCIS-MI患者249例(50.9%)。通过分析患者临床病理数据和随访信息

比较DCIS和DCIS-MI患者在临床病理特征、分子分型及预后等方面的差异。

结果

295例(60.3%)患者初次确诊年龄＜55岁。与DCIS组比较

DCIS-MI组患者具有肿瘤体积偏大(

=0.034)

癌细胞组织学分级高(

0.05)

ER阳性率低(

0.05)等特征; 且DCIS-MI组患者腔面A型比例低(54.6%

63.8%

=0.040)

而HER-2过表达型比例高(18.1%

9.2%

=0.004);两组患者的分子分型分布具有显著性差异(

=0.030)。DCIS组和DCIS-MI组5年无病生存率分别为93.75%和93.17%

差异无统计学意义(Log-rank

=0.074

=0.785)。

结论

DCIS与DCIS-MI具有不同的临床病理特征

分子分型分布迥异

预后差异不明显

提示两者处于乳腺癌进展的不同阶段。

Abstract

Objective

To determine the clinicopathological features and prognostic differences between ductal carcinoma

in situ

(DCIS) and ductal carcinoma

in situ

with microinvasion (DCIS-MI) of breast cancer.

Methods

A cohort of 489 female patients with surgically diagnosed DCIS (

=240

49.1%) and DCIS-MI (

=249

50.9%) in our hospital from January 2004 to December 2014 were recruited in this study. Their clinicopathological data and follow-up data were collected and analyzed for the differences in clinicopathological data

molecular subtypes and prognosis between DCIS and DCIS-MI patients.

Results

The age of initial diagnosis was usually younger than 55 years old (60.3%) in the 2 groups. Compared with DCIS patients

DCIS-MI patients had larger tumor size (

=0.034)

higher histological grade (

0.05)

and lower ER positive rate (

0.05); DCIS-MI patients had lower proportion of luminal-A type (54.6%

63.8%

=0.040)

while higher HER-2 over-expressed type (18.1%

9.2%

=0.004). Statistical differences were seen in the distribution of molecular subtypes between the groups (

Chi

-square=8.921

=0.030). The 5-year disease-free survival rate was 93.75% and 93.17% respectively in the DCIS and DCIS-MI patients

with no significant difference (Log-rank

Chi

-square =0.074

=0.785).

Conclusion

DCIS and DCIS-MI have different clinicopathological features and molecular subtype distribution

but no significant difference in prognosis

which indicates that they may be in different stages of breast cancer progression.

关键词

Keywords

references

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Clinicopathological features and prognostic differences of ductal carcinoma in situ with ductal carcinoma in situ with microinvasion

DOI：10.16016/j.1000-5404.202002067

摘要

Abstract

关键词

Keywords

references