Advances of oligodendrocytes and myelination involving in learning and memory

Zhongxiang YAO; Bo HU

doi:10.16016/j.1000-5404.202002018

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Advances of oligodendrocytes and myelination involving in learning and memory

Neurosciences | 更新时间：2026-01-09

- Advances of oligodendrocytes and myelination involving in learning and memory
- Journal of Third Military Medical University Vol. 42, Issue 9, Pages: 887-890(2020)
- 作者机构：
  
  400038 重庆，陆军军医大学(第三军医大学)基础医学院生理学教研室
- 作者简介：
- 基金信息：
  
  the General Program of National Natural Science Foundation of China(31371147);the General Program of Natural Science Foundation of Chognqing(CSTC2019jcyj-msxmX0424)
- DOI：10.16016/j.1000-5404.202002018
  CLC： R322.81;R338.64
- Received：04 February 2020，
  
  Revised：2020-02-16，
  
  Published：15 May 2020
- 稿件说明：
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Zhongxiang YAO, Bo HU. Advances of oligodendrocytes and myelination involving in learning and memory[J]. Journal of Third Military Medical University, 2020, 42(9): 887-890.
DOI：

Zhongxiang YAO, Bo HU. Advances of oligodendrocytes and myelination involving in learning and memory[J]. Journal of Third Military Medical University, 2020, 42(9): 887-890. DOI： 10.16016/j.1000-5404.202002018.

摘要

神经元活性和学习活动可以调控成年少突胶质细胞的新生，但其功能意义尚不清楚。本文总结近一年来关于少突胶质细胞及髓鞘形成参与学习记忆功能的最新研究进展，探讨少突胶质细胞及髓鞘形成参与学习记忆功能的证据、少突胶质细胞基因表达变化与阿尔兹海默症病程的密切关系，以及少突胶质细胞及髓鞘形成引起学习记忆与认知障碍的药物治疗，并分析了现有研究的不足与未来发展趋势。

Abstract

Neuronal activity and learning can regulate the adult oligodendrogenesis. However

functional significance of this regulation remains not fully clear. Here

we reviewed the most recent progresses in the field of oligodendrocytes and myelination involved in learning and memory. Firstly

we introduce the evidence demonstrating that the oligodendrocytes and myelination are involved in learning and memory. Secondly

we show the gene expression changes of oligodendrocytes

which are closely associated with the progression of Alzheimer's disease. Third

we introduce a few of drug administration which are used to promote oligodendroglial differentiation and myelination and to rescue impairment of learning and memory. At last

we analyze the shortage of current research and propose the trend for future researches.

关键词

Keywords

references

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