Positivity and genotype distribution of HLA-B27 antigen in 7 829 patients with suspected ankylosing spondylitis

Lenyu GAO; Hong WU; Qingxia YOU; Yong WANG

doi:10.16016/j.1000-5404.202001204

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Positivity and genotype distribution of HLA-B27 antigen in 7 829 patients with suspected ankylosing spondylitis

Clinical Medicine | 更新时间：2026-01-09

- Positivity and genotype distribution of HLA-B27 antigen in 7 829 patients with suspected ankylosing spondylitis
- Journal of Third Military Medical University Vol. 42, Issue 12, Pages: 1220-1224(2020)
- 作者机构：
  
  400038 重庆, 陆军军医大学(第三军医大学)第一附属医院风湿免疫科
- 作者简介：
- 基金信息：
- DOI：10.16016/j.1000-5404.202001204
  CLC： R195.4;R392.11;R593.23
- Received：30 January 2020，
  
  Revised：2020-03-22，
  
  Published：30 June 2020
- 稿件说明：
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Lenyu GAO, Hong WU, Qingxia YOU, et al. Positivity and genotype distribution of HLA-B27 antigen in 7 829 patients with suspected ankylosing spondylitis[J]. Journal of Third Military Medical University, 2020, 42(12): 1220-1224.
DOI：

Lenyu GAO, Hong WU, Qingxia YOU, et al. Positivity and genotype distribution of HLA-B27 antigen in 7 829 patients with suspected ankylosing spondylitis[J]. Journal of Third Military Medical University, 2020, 42(12): 1220-1224. DOI： 10.16016/j.1000-5404.202001204.

摘要

目的

通过对重庆地区疑似强直性脊柱炎(ankylosing spondylitis

AS)的患者及部分亲属的人类白细胞表面抗原-B27(HLA-B27)阳性情况进行分析

了解该抗原不同表型在本地区疑似患者中分布的差异。

方法

回顾性分析本院2018年1月1日至2019年11月29日诊治的重庆地区7 829例疑似AS的患者及部分亲属的临床资料

采用序列特异性引物聚合酶链反应(PCR-SSP)法检测血液标本所得的HLA-B27基因亚型的分型情况。

结果

7 829例数据中HLA-B27抗原阳性有2 112例

阳性率为26.98%;其中男性阳性率显著高于女性(33.87%

18.58%

0.01)。其中B* 2704型有1 655例(78.36%)

B*2705/07型有358例(16.95%)。有46例HLA-B27阳性者合并眼部疾病

其中B* 2704型有36例(78.26%)

并且以葡萄膜炎多见(34/46)。

结论

重庆地区人群AS疑似病例HLA-B27抗原阳性率男性明显高于女性。HLA-B27亚型以B* 2704、B* 2705/07为主

且前者是重庆地区AS的发病易感基因亚型。AS合并眼部疾病者以葡萄膜炎多见

HLA-B27基因亚型以B* 2704型为主。

Abstract

Objective

To analyze the positivity of human leukocyte surface antigen-B27 (HLA-B27) in patients with suspected ankylosing spondylitis (AS) and their relatives in Chongqing to understand the gender-specific distribution of HLA-B27 genotypes in the patients.

Methods

We retrospectively analyzed the clinical data of 7 829 patients with suspected AS and some of their relatives

who were diagnosed in Chongqing between January 1

2018 and November 29

2019. HLA-B27 genotypes were determined using a sequence-specific primer polymerase chain reaction (PCR-SSP).

Results

Of the 7 829 patients

2 112 were positive for HLA-B27 antigen

with a positive rate of 26. 98%. The positive rate of HLA-B27 antigen was significantly higher in the male than in the female patients (33.87%

18.58%

0.01). A total of 1 655 (78. 36%) patients had a B* 2704 genotype and 358 (16.95%) had a B* 2705/07 genotype of HLA-B27 antigen. Forty-six of the HLA-B27-positive patients were found to have ocular diseases

among whom 36 (78.26%) patients had a B* 2704 genotype; uveitis was the most frequent ocular disease in these patients (34/46).

Conclusion

The patients with suspected AS in Chongqing have a significantly higher rate HLA- B27 antigen positivity than the normal population

and the positive rate is significantly higher in male than in female patients. The HLA-B27 genotypes are predominantly B * 2704 and B * 2705/07

and the former is associated with AS susceptibility. Uveitis is common in HLA-B27-positive AS patients with ocular diseases

who have a predominant B * 2704 genotype.

关键词

Keywords

references

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