Zhi HU, Chao HE. Progress in brain science in China during 2019[J]. Journal of Third Military Medical University, 2020, 42(5): 431-436.
DOI:
Zhi HU, Chao HE. Progress in brain science in China during 2019[J]. Journal of Third Military Medical University, 2020, 42(5): 431-436. DOI: 10.16016/j.1000-5404.202001185.
and revealing its mystery is considered as the "ultimate territory" in biological science research. Till now
a series of significant progress has been made in the brain science research at the micro and macro levels. Chinese scientists have also made positive contributions to the development of the brain science. In the past year
Chinese scientists have made important achievements in the following aspects: ① the principle of brain functions
such as further revealing the circuitry mechanisms of predatory
defensive and other instinctive behaviors; ② the pathogenesis
diagnosis and treatment of brain diseases
such as the pathogenesis of depression
anxiety
social disorder and the potential new treatment of Huntington's disease; ③ the development and application of new technologies and materials
such as the development of norepinephrine neurotransmitter probe and the application of new nanomaterials that enables mice to obtain infrared light perception. In this article
the representative works are selected and introduced.
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SHANG C P, LIU A X, LI D P, et al . A subcortical excitatory circuit for sensory-triggered predatory hunting in mice[J ] . Nat Neurosci, 2019, 22(6): 909-920. DOI:10.1038/s41593-019-0405-4.
ZHAO Z D, CHEN Z M, XIANG X K, et al . Zona incerta GABAergic neurons integrate prey-related sensory signals and induce an appetitive driv e to promote hunting[J ] . Nat Neuro -sci, 2019, 22(6): 921-932. DOI:10.1038/s41593-019-0404-5.
ZHOU Z, LIU X, CHEN S, et al .A VTA GABAergic neural circuit mediates visually evoked innate defensive responses[J ] . Neuron, 2019, 103(3):473-488.e6. DOI: 10.1016/j.neuron.2019.05.027.
DONG P, WANG H, SHEN X F, et al . A novel cortico-intrathalamic circuit for flight behavior[J ] . Nat Neurosci, 2019, 22(6): 941-949. DOI: 10.1038/s41593-019-0391-6.
SHEN C J, ZHENG D, LI K X, et al . Cannabinoid CB1 receptors in the amygdalar cholecystokinin glutamatergic afferents to nucleus accumbens modulate depressive-like behavior[J ] . Nat Med, 2019, 25(2): 337-349. DOI:10.1038/s41591-018-0299-9.
ZHOU W, JIN Y, MENG Q, et al . A neural circuit for comorbid depressive symptoms in chronic pain[J ] . Nat Neurosci, 2019, 22(10): 1649-1658. DOI: 10.1038/s41593-019-0468-2.
HUANG L, XI Y, PENG Y F, et al . A visual circuit related to habenula underlies the antidepressive effects of light therapy[J ] . Neuron, 2019, 102(1): 128-142.e8. DOI: 10.1016/j.neuron.2019.01.037.
FAN K Q, LI Y Y, WANG H L, et al . Stress-induced metabolic disorder in peripheral CD4+ T cells leads to anxiety-like behavior[J ] . Cell, 2019, 179(4): 864-879.e19. DOI: 10.1016/j.cell.2019.10.001.
SHAO L X, JIANG Q, LIU X X, et al . Functional coupling of Tmem74 and HCN1 channels regulates anxiety-like behavior in BLA neurons[J ] . Mol Psychiatry, 2019, 24(10): 1461-1477. DOI:10.1038/s41380-019-0402-8.
GUO B, CHEN J, CHEN Q, et al .Anterior cingulate cortex dysfunction underlies social deficits in Shank3 mutant mice[J ] . Nat Neurosci, 2019, 22(8):1223-1234. DOI: 10.1038/s41593-019-0445-9.
XU H F, LIU L, TIAN Y Y, et al . A disinhibitory microcircuit mediates conditioned social fear in the prefrontal cortex[J ] . Neuron, 2019, 102(3): 668-682.e5. DOI:10.1016/j.neuron.2019.02.026.
LI Y, LI C Y, XI W, et al . Rostral and caudal ventral tegmental area GABAergic inputs to different dorsal raphe neurons participate in opioid dependence[J ] . Neuron, 2019, 101(4): 748-761.e5. DOI: 10.1016/j.neuron.2018.12.012.
ZHOU Y M, ZHU H W, LIU Z Y, et al . A ventral CA1 to nucleus accumbens core engram circuit mediates conditioned place preference for cocaine[J ] . Nat Neurosci, 2019, 22(12): 1986-1999. DOI:10.1038/s41593-019-0524-y.
SONG J, SHAO D, GUO X, et al . Crucial role of feedback signals from prelimbic cortex to basolateral amygdala in the retrieval of morphine withdrawal memory[J ] . Sci Adv, 2019, 5: eaat3210.
SU X Y, CHEN M, YUAN Y, et al . Central processing of itch in the midbrain reward center[J ] . Neuron, 2019, 102(4): 858-872.e5. DOI: 10.1016/j.neuron.2019.03.030.
LI Z, WANG C, WANG Z, et al .Allele-selective lowering of mutant HTT protein by HTT-LC3 linker compounds[J ] . Nature, 2019, 575(7781): 203-209. DOI: 10.1038/s41586-019-1722-1.
FENG J, ZHANG C, LISCHINSKY J E, et al . A genetically encoded fluorescent sensor for rapid and specific in vivo detection of norepinephrine[J ] . Neuron, 2019, 102(4): 745-761.e8. DOI: 10.1016/j.neuron.2019.02.037..
SUN Q T, LI X N, REN M, et al . A whole-brain map of long-range inputs to GABAergic interneurons in the mouse medial prefrontal cortex[J ] . Nat Neurosci, 2019, 22(8): 1357-1370. DOI: 10.1038/s41593-019-0429-9.
MA Y Q, BAO J, ZHANG Y W, et al . Mammalian near-infrared image vision through injectable and self-powered retinal nanoantennae[J ] . Cell, 2019, 177(2): 243-255.e15. DOI:10.1016/j.cell.2019.01.038.
COOK S J, JARRELL T A, BRITTIN C A, et al .Whole-animal connectomes of both Caenorhabditis elegans sexes[J ] . Nature, 2019, 571(7763):63-71. DOI: 10.1038/s41586-019-1352-7.
MARQUES J C, LI M, SCHAAK D, et al . Internal state dynamics shape brainwide activity and foraging behaviour[J ] . Nature, 2020, 577(7789): 239-243. DOI:10.1038/s41586-019-1858-z.
LUKOWSKI S W, LO C Y, SHAROV A A, et al . A single-cell transcriptome atlas of the adult human retina[J ] . EMBO J, 2019, 38(18): e100811. DOI: 10.15252/embj.2018100811.
MOFFITT J R, BAMBAH-MUKKU D, EICHHORN S W, et al . Molecul ar, spatial, and functional single-cell profiling of the hypothalamic preoptic region[J ] . Science, 2018, 362(6416): eaau5324. DOI:10.1126/science.aau5324.
ZHONG S J, ZHANG S, FAN X Y, et al . A single-cell RNA-seq survey of the developmental landscape of the human prefrontal cortex[J ] . Nature, 2018, 555(7697): 524-528. DOI:10.1038/nature25980.
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